Associações anestésicas baseadas em fármacos dissociativos reduzem a pressão intraocular (PIO) em coelhos

The aim of this study was evaluate the effects of three anesthetic combinations, ketamine-midazolam, ketamine-xylazine and tiletamine-zolazepam, on IOP in rabbits. In a experimental, blind, randomized, crossover study, six rabbits were anesthetized with each of 3 treatments in random order. Groups KM (ketamine, 30 mg/kg + midazolam, 1 mg/kg); KX (ketamine, 30 mg/kg + xylazine, 3 mg/kg); and TZ (tiletamine + zolazepam, 20 mg/kg). The drugs were mixed in the same syringe injected intramuscularly (IM) into the quadriceps muscle. IOP was measured before drug administration (baseline) and at 5-minute intervals for 30 minutes. The data were analyzed by a 2-way repeated measures ANOVA followed by Bonferroni test. All groups had significant decreases in IOP compared to baseline (p < 0.001). There was no difference between groups at any of the time points assessed (p > 0.05). Administration of either ketamine-midazolam, ketamine-xylazine, or tiletamine-zolazepam similarly decrease IOP in rabbits within 30 minutes of injection.

Influência que o estado de ânimo gerado por exercícios sistematizados e não sistematizados provoca na pressão arterial de idosos normotensos e hipertensos

A hipertensão arterial atinge uma média de 20% a 25% da população brasileira. Estudos apontam que a prática regular de atividade física além de combater o sedentarismo pode ser utilizada como meio não farmacológico de tratamento e prevenção da hipertensão. Objetivo: Verificar os efeitos do estado de ânimo gerado por exercícios não sistematizados e sistematizados na pressão arterial. Metodologia: Participaram do estudo 30 alunas que participam há mais de seis meses do Programa Saúde Ativa Rio Claro. Elas receberam treinamento duas semanas, para utilizarem o aparelho de pressão digital de pulso Fuzzy LOGIC. As participantes foram submetidas a 3 sessões de aulas (aeróbio, lúdico e força) em dias diferentes. As aulas do aeróbio contavam com 40 min de caminhada moderada, a aula de força constou 3 séries de 1 minuto, com intervalo entre as séries de 30 segundos para membros superiores e inferiores e a aula lúdica com brincadeiras não padronizadas. As aulas foram constituídas de alongamento (10 min), parte principal (40 min) e volta à calma (10 min). A pressão arterial sistólica (PAS) e diastólica (PAD) foram aferidas nos momentos: repouso (M1), término (M2), 30 minutos após a sessão (M3), 4 horas após (M4) e 8 horas após a sessão dos exercícios (M5). A análise estatística utilizada foi a Anova para medidas repetidas com 2 fatores (Momentos e Tipo de aula) com significância de p<0.05. Resultados: A PAS no M3 foi menor do que no M1 e M2 para todos os protocolos (p<0.05); para a PAD o M3 apresentou valores menores do que o M1 e M2 para todos os protocolos. Conclusão: O efeito hipotensor teve resultados mais significativos quando relacionado a prática dos exercícios do que aos estados de ânimo gerados pelos mesmos. A prática da atividade física foi capaz de alterar positivamente os estados de ânimo dos indivíduos... (Resumo completo, clicar acesso eletrônico abaixo)

Efeito da aplicação do fluido de corte na usinagem da superliga Nimonic 80A

The nickel alloys have a chemical composition with high tenor of alloy elements which are responsible for the material's mechanical and thermal properties, but also are the main causative of problems during the machining, making the process difficult. The objective of this work is the study of the machining by external cylindrical turning of the nickel based alloy Nimonic 80A, seeking the machining optimization of this alloy, seeking the best condition of lubricant fluid use, providing real increases of productivity without the need of investments in new production means. Besides, the results of this work should offer more detailed information regarding the behavior of this alloy in relation to machining by turning. The machining experiences were accomplished in a specimen of the nickel alloy, considering the machining parameters: cutting speed (75 and 90 m/min), cutting depth (0,8 mm) and feed rate (0,15 and 0,18 mm/v). The valuations were accomplished in a CNC lathe and tools with of hard metal inserts. After each stage of the turning the measures of the cutting length were accomplished, of the waste of the tools through a magnifying glass (8x) and the roughness of the specimen evaluated in each phase of the process, with the aid of a portable roughness meter. Through light optical microscopy it was possible to observe the wear of the cutting tools for each appraised condition. The roughness values, Ra and Ry, for the appraised conditions were always superiors to the theoretical values. After analysis of the results it was possible to end that, the best acting for this work strip tested it was obtained for ap=0,8mm: f=0,15mm/rev and VC=75m/min, what resulted in a larger cutting length (1811 m)

Estudo do fenômeno de instabilidade de estruturas cilíndricas de paredes finas submetidas ao carregamento de pressão externa

Thin walled cylindrical shells are widely used in many areas of industry, including civil, mechanical, nuclear, marine, petroleum and aerospace engineering. The wide application of thin cylindrical shells and the importance of instability phenomenon are the motivation basis to this study, since these factors have a great importance in engineering projects. It is presented a detailed study about the instability of cylindrical shells based on theoretical calculation, which results are compared with finite elements method calculation. The loading and boundary conditions analyzed are based on the most common types verified in real engineering projects and refer respectively to lateral (external) pressure and cylinders with simply supported edges. The calculation based on the finite elements method was executed with ANSYS 13.0 software. The results obtained with this calculation are in good agreement with the analytical theory presented in the technical note NACA No 1341 (BATDORF, 1947) considering a wide range of applicability. On the other hand, the analytical method presented in the book Theory of Elastic Stability (TIMOSHENKO; GERE, 1936) has a very restrict applicability and has presented considerable deviations in a great sort of the analyzed cases

Análise crítica de um vaso de pressão do setor sucroalcooleiro

This study aims to evaluate structurally a heat exchanger that has been in operation since the mid-60's and was built COSAN for operation in one of its sugar production plants in São Paulo, this equipment as well as many similar devices are operation in plants throughout Brazil, and thus to be acquired by large corporations as in the case of COSAN, pass the scrutiny of inspection work, and work such as recalculations in the latter case in structural evaluations to verify the possible need for adjustments to project or operation and thus ensure the structural integrity of the equipment. To this were first done field survey using techniques of NDT and NDT's for determining the thickness of the main parts of the equipment, made the revaluation dimensional and existing project and considering the loads operating performing the characterization of the equipment as specified in the standard regulatory number 13 - NR13 and the other for this type of equipment and finally an analysis using a static approach, as an analysis tool using the finite element method

Caracterização petrográfica e geoquímica das rochas encaixantes da mineralização de ouro do alvo lavra velha - Ibitiara (BA)

The Lavra Velha gold prospect is located in Ibitiara city, in the Espinhaço Setentrional physiographic domain, on the west edge of Chapada Diamantina – central part of Bahia. It is inserting on Gavião Block, a compartment of São Francisco Cráton (Almeida, 1977). The Lavra Velha gold dump is formed by an association of hydrothermal breccia lodged in acid and intermediate rocks, classifying in tonalite, granodiorite and diorite, with high alteration, cut off by a vein and venules system constituted by hydrothermal association composed by hematite, tourmaline, quarz and sericite, located in the north limit of Ibitiara granite. In the regional geological context the area is represented by Archaean rocks (Paramirim Complex) and Paleoproterozoic rocks (Ibitiara granitoid and Matinos Granite) constituted the basement, following by paleo to mesozoic pluton-vulcanic-sedimentary association of Rio dos Remédios Group, intruded by mafic rocks. It was used geochemistry and petrographic analysis compiling to field works data to characterize the rocks where the gold mineralization is inserting. Previously these rocks were classifying in volcanic rocks of Novo Horizonte Formation. Developing this monograph’s work the petrogenetic characteristics suggesting that these rocks called volcanic actually belong to Ibitiara granitoid as a portion more metamorphosed. The green schist is the predominant metamorphism in the area with low deformation, associated to high concentration of fluid circulating. The hydrothermal alteration is the process responsible for rocks modifications and strong sericitization generalize

Efeito da pressão expiratória positiva oscilante na transportabilidade e medida do ângulo de adesão do muco brônquico

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Influência dos polimorfismos para o gene da sintase do óxido nitrico endotelial (eNOS) na pressão arterial e perfil lipídico em resposta ao treinamento físico em mulheres no climatério

A incidência de doenças cardiovasculares tem se constituído na maior causa de morbimortalidade em todo mundo, especialmente após os 50 anos de idade, e têm sido associadas à presença de polimorfismos em alguns genes, especialmente o gene da eNOS. Apesar das mulheres compartilharem com os homens os diversos fatores de risco para o desenvolvimento das doenças cardiovasculares, entre elas hipertensão arterial e dislipidemia, estudos epidemiológicos mostram que as mesmas, antes da menopausa, apresentam menor risco cardiovascular quando comparadas aos homens. Entretanto, após o período da menopausa há um aumento significativo na incidência de hipertensão arterial e suas complicações. Este fato parece estar relacionado a uma possível ação protetora exercida pelos hormônios sexuais femininos, sobretudo os estrogênios que apresentam queda abrupta no período da menopausa. O óxido nítrico (NO), produzido pelas células endoteliais através da enzima eNOS, desempenha importante papel no sistema cardiovascular, participando na regulação do fluxo sanguíneo, do remodelamento vascular e na atividade plaquetária. Assim, estudos envolvendo o gene responsável pela síntese da enzima eNOS, tem sido foco de várias pesquisas na tentativa de avaliar se a presença dos polimorfismos poderia predispor os indivíduos a maior incidência de doenças cardiovasculares. O polimorfismo do gene da eNOS na posição G894T/Glu298Asp localizado no éxon 7, implica na alteração da sequência protéica, tornando a proteína mais suscetível à clivagem, tendo consequências funcionais como a redução do NO demonstrando assim sua provável contribuição para a disfunção endotelial e consequente aumento da pressão arterial. Com relação ao Íntron 4 caracterizado por um Número Variável de Repetições em Tandem... (Resumo completo, clicar acesso eletrônico abaixo)

Efeito agudo de uma sessão de exercícios aeróbios e resistidos na pressão arterial de indivíduos normotensos e hipertensos pertencentes ao Programa de Atividade Física na UBS e PSF do município de Rio Claro-SP

A hipertensão arterial (HA) é fator de risco para o desenvolvimento de doenças cardiovasculares, uma forma de prevenção seria a adoção de um estilo de vida mais ativo.O estudo tem como objetivo verificar se uma sessão de exercícios resistidos e aeróbios provoca efeito hipotensivo em indivíduos normotensos e hipertensos sendo a P.A aferida antes e depois dos exercícios. Participaram do estudo 29 indivíduos, normo e hipertensos, com idade média de 54,96 anos ( ± 9,56 ), todos participantes do projeto de atividade física para diabéticos e hipertensos, desenvolvido pelo NAFES da UNESP – Rio Claro. A aula constituiu-se de aquecimento e alongamento (10 min), parte principal (40 min) dividida por: Caminhada (10 min), exercícios resistidos de membro superior utilizando halteres de um quilo (10 min), caminhada (10 min) e exercícios resistidos de membros inferiores com peso corporal (10 min), finalizando com volta calma(10 min). A Pressão Arterial foi aferida através de aparelho digital de pulso Fuzzy LOGIC, Model 3001, BioLand em repouso(M1), ao termino(M2), 30 minutos pós-exercícios(M3) e 4 horas após o termino dos exercícios(M4). Os dados foram analisados por meio do ANOVA para análises repetidas, através do programa Statistic 7.0 e significância de p<0,05. A analise estatística mostrou que na pressão sistólica não houve diferença significante do M1(137,6 ±17,1mmHg) para o M3(133,9 ±18,8mmHg) enquanto que na pressão diastólica observou-se diferença significativa do M1(84,7 ±9,3mmHg) para o M4(80,7 ±11.2mmHg). Conclusão: Houve efeito hipotensor após exercícios apenas na pressão diastólica, já na pressão sistólica não ocorreu mudança significativa embora todos os valores pós exercícios tenham diminuído, tanot na sistólica quanto na diastólica.

Entendendo a pressão arterial

Este trabalho teve o objetivo elaborar e produzir uma cartilha informativa com noções fisiológicas básicas envolvidas no controle da pressão arterial, bem como a descrição da hipertensão e prevenção destinadas a alunos a partir do Ensino Médio, pois além da hipertensão arterial ser uma doença crônica que se caracteriza pela elevação da pressão arterial sistêmica persistente e compor um dos fatores de risco cardiovasculares mais importantes e comuns, apresentando altos índices de morbidade e mortalidade em todos os grupos populacionais, o conceito de pressão arterial e a importância da manutenção dos níveis pressóricos normais devem ser difundidos, a fim de auxiliar no autocuidado com a saúde. Para a formulação adequada da cartilha realizou - se um estudo prévio com 60 alunos de Ensino Médio de uma escola municipal de Botucatu, e através de um questionário avaliamos quantitativamente e qualitativamente por análise de conteúdo: vocabulário, conceitos, interesse sobre pressão arterial e temas interligados. Os dados gerados na análise de conteúdo propiciaram a formulação da cartilha

Caracterização física e mecânica de compensado produzido com dois diferentes adesivos em duas variações de pressão de prensagem

The adhesives used in the production of engineered boards have been object of study over the years in order to improve the properties of the boards with less energy consumption, lower production costs and reduced environmental impact. In addition to that, process variables may affect the properties of the board. The present study aimed to characterize sheets of plywood, manufactured with two types of adhesives, under two different pressing conditions. The adhesives used for the study were Phenol-formaldehyde and Polyurethane castor oil based. The pressure of pressing was varied in a range from 75 to 160 Bar, in order to verify how they influence the physical and mechanical properties of the board. The tests performed resulted in a conclusion that shows that the moister content of the veneers interferes on the physical and mechanical tests. In general, boards produced with polyurethane resin showed superior physical and mechanical results; although the ones produced with phenol formaldehyde at a pressure of 75 Bar had always equal or higher values, compared to what is found in literature

Comparação de dois métodos de profilaxia dental: avaliação da pressão arterial e do conforto do paciente. Ensaio clínico controlado e randomizado

GOALS: This research evaluated the change in arterial pressure before and after two procedures of dental prophylaxis: Jet system baking soda and conventional prophylaxis and patient's opinion regarding the comfort of each one. MATERIAL AND METHOD: Were selected 32 patients with age between 18 to 30 years old, who need prophylaxis to remove biofilm and were subjected to three different types of treatment: sodium bicarbonate jet (G1), prophylaxis conventional (G2) and placebo (G3) at intervals of one month between them. Patients were divided randomly. Arterial pressure was measured by wrist digital Omron HEM – 6111. The measurements were realized in four times: before the prophylaxis, immediately the end of procedure, 15 and 30 minutes after finished of treatment. Patient comfort was measured by a Visual Analog Scale (VAS) after the end of the treatment. The data were analyzed using the variance test. The results showed that there was statistically significant difference to the comfort of the procedures. RESULTS: There was a statistically significant difference to the comfort of the procedures, and G2 and G3 better than G1. Regarding the variation of arterial pressure there was no statistically significant difference between groups. CONCLUSIONS: The methods of prophylaxis no effect on arterial pressure, but conventional prophylaxis is more comfortable than others treatments

Atividade diurética dos extratos aquoso e etanólico de Bugre (Hedyosmum brasiliense Miq.) e seus efeitos na pressão arterial média em testes pré-clÍnicos

The object of this study was assess through pre-clinical tests, the possible diuretic activity and the effects on the mean arterial pressure of the aqueous and ethanolic extracts of branches of “bugre”, Hedyosmum brasiliense Miq., species used in the treatment of renal and urinary disorders The tests were made in males anesthetized Wistar rats and randomly distributed into 4 experimental groups: Group I – Water control, group II – treated with aqueous extract (EA) of “bugre”, Group III – water control + “tween 80”, group IV – treated with ethanol extract (EE) and “bugre”. All groups were subjected to experimental protocol, composed of three periods: Balance (40 minutes), Basal (30 minutes) and Experimental (90 minutes), occurring the urine collection every 30 minutes, from the basal period and measuring blood pressure every 10 minutes. The results presented validate the ethnobotany indication of the use of H. brasiliense tea in the treatment of renal problems, because increased significantly the urinary flow in anesthetized Wistar rats (diuretic effect), without changing significantly (p>0,05) the arterial pressure

Análise preliminar para a estimativa da perda de calor sensível de um fluido homogêneo térmico em um reservatório de geometria cilindrica

This work analyzed the loss of sensible heat from one fluid to be considered homogeneous heat distribution on a thermal reservoir with cylindrical geometries composite insulating layers. We studied two thermal reservoirs with a volume of 20 liters, and the first has a layer thickness of 75 mm of expanding polyurethane foam wrapped in the polycarbonate container and the second container has only layer thickness of 5 mm of polycarbonate, as insulation of fluid of the external environment. The experimental results are compared with theoretical results obtained through a calculation script, displayed and detailed during the work development, from the theory of energy balance. The maximum error introduced between the theoretical and experimental results were 3.5% and 1.4% respectively for the Boilers with or without a polyurethane coating

Avaliação de funcionamento das bombas hidráulicas do sistema de tratamento de efluentes da Empresa Parker Hannifin

On the field of the projects of hydraulic systems exists a lot of worries when we talk about the calculate of hydraulic pumps. In this case some facts must be considerate: length of tubes, fluid characteristics, height gauge, temperature, pressure, characteristics of tubes, flow required and others. For that mathematic calculates must be developed with the objective to optimize hydraulic pumps and agree to find an ideal machine (that don't requires more energy than necessary or less energy than it requires; that is the more critical case, cause exists the risk that the fluid pumped do not agree to become in your destiny). The wrong calculate of this machine can super-size its, bringing an excessive energy consumption. Actually it's an important subject because we are in the age of lack of energy what turn it more expensive. So the correct sizing of a hydraulic pump is connected with the fact that you have to uses the enough energy resources avoiding waste. The calculate of ideal pump in the pumping system is studied during years and a lot of specialists in this subject develop equations and theories to calculate its. Some researches study about this subject and all of them become to the same conclusion: to find the ideal pump we have to know the characteristics of fluid (cinematic viscosity), the required flow , overall yield (overall of motor x overall of pump) the high gauge or discharge pressure and the loss of repression. The pressure drop can be calculated with different theories: using Hazen-Williams, Darcy e Weisbach or Chézy (1775 - that starts the researches to calculate the pressure drop). Although the most used theory and what is most near to reality is the Darcy's equation. So, in this job the Darcy's equation were choice to calculate the drop pressure that consider what kind of flow we are studying: laminar or turbulent. The determination of the best pump to be used in the ... ( complete abstract click eletronic access below)