219 resultados para Fibrin clot


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Pós-graduação em Ciência Odontólogica - FOA

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Objective: This study aims to compare the clot stabilization on root surfaces conditioned with citric acid and ethylenediaminetetraacetic acid (EDTA). Materials and methods: Scaled root samples (n = 100) were set in five groups: group I?control group (saline solution); group II (24% EDTA); group III (25% citric acid); group IV (EDTA + citric acid); group V (citric acid + EDTA). Fifty samples were assessed using the root surface modification index (RSMI). The other 50 received a blood drop after conditioning. Clot formation was assessed using blood elements adhesion index (BEAI). A blind examiner evaluated photomicrographs. Statistical analysis considered p < 0.05. Results: Groups-III and G-V attained the best results for RSMI and BEAI in comparison to control. The worst results for clot stabilization were seen in group-II. EDTA employment before citric acid (group-IV) reduced clot formation in comparison to citric acid use alone (group-III). Conclusion: Root conditioning with citric acid alone and before EDTA had the best results for smear layer removal and clot stabilization. EDTA inhibited clot stabilization on root surface and must have a residual activity once it has diminished clot adhesion to root even after citric acid conditioning. Thus, EDTA can be used to neutralize citric acid effects on periodontal cells without affecting clot stabilization. Clinical significance: To demonstrate that citric acid use on root surfaces previously affected by periodontal disease may favor clot stabilization and may have a beneficial effect on surgical outcomes. Also, EDTA can be used to neutralize citric acid effects on periodontal cells.

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The aim of this study was to evaluate and compare the repair of bone defects filled with calcium aluminate cement (EndoBinder), mineral trioxide aggregate (MTA), and calcium hydroxide. Methods After mixing, the cements were inserted into bone defects (3.3 mm) mechanically created in the right and left tibias of 30 rats (Rattus norvegicus, Wistar). In the control group, the bone defects were filled with blood clot of the animal itself. After time intervals of 7, 30, and 90 days had elapsed, bone tissue biopsies (n = 5) were surgically obtained and submitted to laboratory processing. The response of bone tissue in contact with the materials was microscopically analyzed. The percentage of neoformed bone tissue in the defect was determined by means of planimetry counting points superimposed on the histologic image. Results Significant increase in the percentage of neoformed bone tissue was observed throughout the experimental periods in all groups (P < .05). For the cements EndoBinder and MTA (30 and 90 days), these percentage values were statistically higher than those of the control group (P < .05); however, they were similar to those of calcium hydroxide (P > .05). Conclusions EndoBinder and MTA allowed complete repair of bone defects created in rat tibias.

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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The objective of this study was to present the use of selfconfrontation in applied linguistics (AL) research on teachers’ activities. Selfconfrontation was developed by Faïta (1997), and improved by Clot (2006) within the context of Activity Clinics. It is a device that attempts to capture the multiple discourses around an activity and enable its transformation by workers. Thus, a qualitative research approach was employed and documental analysis of theses, dissertations and papers abstracts produced in Brazil (1987 to 2011), available in the electronic site of CAPES, was performed. The results demonstrated that selfconfrontation is used in a fragmented manner in AL studies that examine teachers’ activities, being primarily used for the collection of data, with little emphasis being placed on the transformation of the labor process.

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This article presents an academic and scientific study about the use of the device methodological and intervening of selfconfrontation in research in post-graduate studies in Education in Brazil. The self-confrontation is a device created by linguist Daniel Faïta and perfected by psychologist Yves Clot. She seeks to capture the multiple discourses and perspectives around a particular craft, integrating researcher and workers to facilitate the installation of a dialectical movement of analysis and production of knowledge about the work, ownership of these knowledge workers and the collective transformation of labor activity. We chose a qualitative approach and the realization of documental analysis of the abstracts of researches that resulted in the production of doctoral theses and dissertations held in Brazil between 1987 and 2011. Were examined studies that had their abstracts gathered and made available by the Coordenadoria de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) on its website. The results show that self-confrontation is used piecemeal studies produced in the area of Education, used primarily to collect data and to give less emphasis to the transformation of the labor process.

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To quantify fibrin degradation products after topical and subconjunctival administration of recombinant tissue plasminogen activator in rabbits. Methods: Fibrin formation was induced in the anterior chamber in 25 rabbits. Subsequently, five rabbits received an injection of r-TPA (positive control) in the anterior chamber, another 10 received a subconjunctival injection of r-TPA, and the remaining 10 received instillations of topical r-TPA. Afterwards, samples of aqueous humor were collected and semi-quantitative analysis of fibrin degradation products (FDP) was performed. Results: No statistical differences were noted between the treatment and control groups at any time point. Fibrin degradation products semi-quantification showed statistical improvement in the control group and the subconjunctival group. Conclusion: Fibrin degradation products were observed in the anterior chamber after subconjunctival administration of r-TPA. However, it was probably not sufficient to cause fibrin degradation. Topical r-TPA did not effectively absorb anterior chamber fibrin.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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In the treatment of extrusive luxation cases, it is important that the repositioning of extruded tooth in the socket is done as soon as possible. If this does not occur, periapical clot becomes organized and makes replantation difficult reposition. In this article the patient referred to the Clinics for dental trauma sustaining extrusive luxation of the maxillary right central incisor. The patient reported having suffered a bicycle accident 12 days before, which caused traumatic tooth injuries. The repositioning was attempted without success and an alternative form of treatment was necessary to solve the case. Intentional tooth replantation, which is the deliberate extraction of the tooth and its replantation, was indicated. This technique allows clot removal and correct repositioning of the extruded tooth. Care should be taken as endodontic treatment is required for the prevention of subsequent infection-related resorption. Intracanal dressing with calcium hydroxide was used for 30 days before final root filling. Splint, systemic antibiotics and avoidance of further damage to the root surface is also important. After 49 months, showed clinical and radiographic characteristics of normality and demonstrates the availability of this technique to adversity in trauma.