Immunohistochemical and molecular expression of laminin-332 gamma-2 chain in canine mammary tumors

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

MEH-PPV hypsochromic shifts in halogenated solvents induced by gamma-rays

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Interferon-gamma+874 Polymorphism in the First Intron of the Human Interferon-gamma Gene and Kidney Allograft Outcome

Background. Despite advances in immunosuppressive therapy in the past decade, allograft rejection remains an important cause of kidney graft failure. Cytokines play a major role in the inflammatory and immune responses that mediate allograft outcomes. Several studies have shown that the production of cytokines varies among individuals. These variations are determined by genetic polymorphisms, most commonly within the regulatory region of cytokine genes. The aim of the present study was to assess the effect of allelic variation on acute rejection episodes (ARE) or chronic allograft nephropathy (CAN) after kidney transplantation.Methods. To determine a possible correlation between the interferon (INF)-gamma +874 polymorphism and kidney allograft outcome, we isolated genomic DNA from 74 patients who underwent isolated kidney allografts and were classified into 2 groups-a rejection and a nonrejection group-for comparison with a control group of 163 healthy subjects.Results. We genotyped INF-gamma +874 polymorphisms in all groups. The transplant group showed a significantly increased homozygous genotype T/T (P = .0118) compared with healthy controls. Similarly, considering only patients with CAN, the homozygous genotype T/T (P = .0067) was significantly increased compared with the healthy controls. The rejection group indicated a significant increased homozygous genotype Tic compared with the control group (P = .0061).Conclusion. Homozygous genotype T/T was associated with increased levels of INF-gamma and greater numbers among the rejection and CAN cohorts.

Porosity measurement of solid pharmaceutical dosage forms by gamma-ray transmission

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

(alpha + gamma(1)) Complex phase formation in the Cu-10 mass% Al-6mass% Ag alloy

In this work the (alpha + gamma(1)) complex phase formation reaction in the Cu-10mass% Al-6mass% Ag alloy was studied using Differential Scanning Calorimetry (DSC), Differential Thermodilatometry (DTD), X-ray diffractometry (XRD), Optical (OM) and Scanning Electron Microscopies (SEM). The results indicated the presence of two different processes, related to a change in the Ag diffusion route from the alpha matrix to the (alpha + gamma(1)) complex phase.

Analytical optimization of spread and change of exponential decay of generalized Wannier functions in one dimension

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Some effects of gamma-irradiated autologous sera on their donors

The present paper is a further step to elucidate the effect of γ-irradiated molecules and their action as immunogens. Rabbits were bled, the total serum was γ-irradiated and reinjected to the autologous donor. Bleeding and reinjection of non-irradiated serum do not produce any alteration hence the animal is able to recognize the autologous unmodified serum proteins as 'self'. Electrophoretic results demonstrate that as an effect of γ-irradiation, alteration of the normal migration properties are occurring. The obtained data are suggesting that due to the possible alteration of the molecular structure, resulting as the effect of γ-rays, the antibody forming system of the animal injected with irradiated autologous serum might recognize the substances as 'not self' what may be the possible reason of antibody formation. The presence of antibodies and probably their complexes with antigens are demonstrated by cutaneous sensibilization technics. The low level of the complement starting from the 7-9 days, the histological alteration of the kidney and the cardiac lesions are tempting to try an interpretation comparing these symptoms to those observed in serum sickness.

Decay of protons and neutrons induced by acceleration

We investigate the decay of accelerated protons and neutrons. Calculations are carried out in the inertial and coaccelerated frames. Particle interpretation of these processes are quite different in each frame but the decay rates are verified to agree in both cases. For the sake of simplicity our calculations are performed in a two-dimensional spacetime since our conclusions are not conceptually affected by this. ©1999 The American Physical Society.

Comment on Majoron emitting neutrinoless double beta decay in the electroweak chiral gauge extensions

We point out that if the Majoron-like scheme is implemented within a 3-3-1 model, there must exist at least three different mass scales for the scalar vacuum expectation values in the model. ©1999 The American Physical Society.

Weak decay of uniformly accelerated protons and related processes

We investigate the weak interaction emission of spin-1/2 fermions from accelerated currents. As particular applications, we analyze the decay of uniformly accelerated protons and neutrons, and the neutrino-antineutrino emission from uniformly accelerated electrons. The possible relevance of our results to astrophysics is also discussed.

Decay of accelerated protons and the existence of the Fulling-Davies-Unruh effect

A theoretic-oriented strategy was taken to address the weak decay of uniformly accelerated protons. The decay of uniformly accelerated p+'s was analyzed using standard quantum field theory (QFT). It was shown that the FDU effect is essential to reproduce the proper decay rate in the uniformly accelerated frame.

Neutrinoless double beta decay with and without Majoron-like boson emission in a 3-3-1 model

We consider the contributions to the neutrinoless double beta decays in a SU(3)L⊗U(1)N electroweak model. We show that for a range of parameters in the model there are diagrams involving vector-vector-scalar and trilinear scalar couplings which can be potentially as contributing as the light massive Majorana neutrino exchange one. We use these contributions to obtain constraints upon some mass scales of the model, such as the masses of the new charged vector and scalar bosons. We also consider briefly the decay in which, in addition to the two electrons, a Majoron-like boson is emitted. ©2001 The American Physical Society.

Search for the flavor-changing neutral current decay Bs 0 → μ+ μ- pp̄ Collisions at √s = 1.96 TeV with the DO Detector

We present the results of a search for the flavor-changing neutral current decay Bs 0 → μ+ μ-. using a data set with integrated luminosity of 240 pb-1 of pp̄ collisions at √s = 1.96 TeV collected with the D0 detector in run II of the Fermilab Tevatron collider. We find the upper limit on the branching fraction to be B(Bs 0 → μ+ π-) ≤ 5.0 × 10-7 at the 95% C.L. assuming no contributions from the decay Bd 0 → μ+ μ- in the signal region. This limit is the most stringent upper bound on the branching fraction Bs 0 → μ+ μ- to date. © 2005 The American Physical Society.

Measurement of the pp(-)-> W gamma plus X cross section at root s=1.96 TeV and WW gamma anomalous coupling limits

The WWγ triple gauge boson coupling parameters are studied using pp̄rarr; νγ+X(=e,μ) events at s=1.96 TeV. The data were collected with the D0 detector from an integrated luminosity of 162pb-1 delivered by the Fermilab Tevatron Collider. The cross section times branching fraction for pp̄→W(γ)+X→ νγ+X with ETγ>8 GeV and ΔR γ> 0.7 is 14.8±1.6(stat)±1.0(syst) ±1.0(lum)pb. The one-dimensional 95% confidence level limits on anomalous couplings are -0.88<Δκγ<0.96 and -0. 20<λγ<0.20. © 2005 The American Physical Society.

Simple analytical expression for vector hypernuclear asymmetry in nonmesonic decay ofΛ 5He andΛ 12C

We present general explicit expressions for a shell-model calculation of the vector hypernuclear parameter in nonmesonic weak decay. We use a widely accepted effective coupling Hamiltonian involving the exchange of the complete pseudoscalar and vector meson octets (π, η, K, ρ, ω, K*). In contrast to the approximated formula widely used in the literature, we correctly treat the contribution of transitions originated from single-proton states beyond the s-shell. Exact and simple analytical expressions are obtained for the particular cases of Λ 5He and Λ 12C, within the one-pion-exchange model. Numerical computations of the asymmetry parameter, aΛ, are presented. Our results show a qualitative agreement with other theoretical estimates but also a contradiction with recent experimental determinations. Our simple analytical formulas provide a guide in searching the origin of such discrepancies, and they will be useful for helping to solve the hypernuclear weak decay puzzle.