Derivados ftalimídicos de compostos antiinflamatórios não-esteróide e/ou moduladores de TNF-(alfa), processo de sua obtenção, composições farmacêuticas contendo os mesmos e seus usos no tratamento de doenças inflamatórias

The present invention relates to phthalimide derivatives of non-steroidal and/or TNF-+- modulating anti-inflammatory compounds as well as the process of obtaining the so-called derivatives, pharmaceutical compositions containing such derivatives and their uses, including use in the treatment of inflammatory diseases, especially those related to chronic inflammatory processes, such as rheumatoid arthritis and intestinal inflammatory diseases (for instance, Chron's disease) and the use of the referred to pharmaceutical compositions as antipyretic, analgesic and platelet antiaggregating medications.

Processo de obtenção de compostos derivados de anti-inflamatários esteráides (aies), composições farmacêuticas contendo tais compostos e seus usos no tratamento de doenças de caráter inflamatário

A presente invenção se refere ao processo de obtenção de compostos derivados de anti-inflamatórios esteróides (AIEs) e de talidomida com propriedades anti-inflamatórias, analgésicas e imunossupressoras úteis no tratamento de processos inflamatórios. A presente invenção se refere também as composições farmacêuticas contendo tais compostos e seus usos na fabricação de medicamentos para o tratamento de doenças inflamatórias principalmente aquelas relacionadas a processos inflamatórios crônicos.

Uso de compostos derivados ftalimídicos e/ou sulfonamídicos no tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-alfa e a necessidade de uma fonte exógena de óxido nítrico, compostos derivados ftalimídicos, compostos derivados sulfonamídicos, método de obtenção de um composto derivado sulfonamídico

A presente invenção se refere ao uso de compostos derivados ftalimídicos e/ou sulfonamídicos com propriedades doadoras de óxido nítrico, os quais apresentam importantes atividades no aumento da expressão gênica de gama globina e atividades antiinflamatórias e analgésicas, potenciais ao tratamento de doenças hematológicas em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico. Mais particularmente, a presente invenção descreve o uso de tais derivados ftalimídicos e/ou sulfonamídicos para o tratamento de anemia falciforme. A invenção também apresenta como característica inovadora, a descrição de novos derivados ftalimídicos funcionalizados, desenhados a partir dos protótipos talidomida e hidroxiuréia e planejados racionalmente através da estratégia de hibridação molecular para o tratamento das doenças citadas. A invenção apresenta ainda um novo método de obtenção de um derivado sulfonamídico específico que pode ser utilizado na preparação de um medicamento para tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico.

Uso de compostos derivados ftalimidicos e/ou sulfonamídicos no tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-alpha e a necessidade de uma fonte exógena de óxido nítrico, compostos derivados sulfonamídicos. Método de obtenção de um composto derivado sulfonamídico

Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-[alpha] levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.

Os 600 transplantes renais do Hospital das Clínicas da Faculdade de Medicina de Botucatu (HC da FMB) - UNESP: Mudanças ao longo do tempo

Introdução:Os resultados alcançados pelos transplantes renais nas últimas décadas têm melhorado progressivamente. Objetivo:A fim de determinar a extensão desse progresso, conduzimos uma análise dos resultados obtidos em nosso programa de transplantes através de três períodos diferentes. Métodos:Avaliamos os 600 transplantes renais realizados no HC FMB-UNESP até dezembro de 2011, subdividindo-os em três eras, de acordo com a imunossupressão vigente. Era 1: de 1987 a 2000 (n = 180); associação de ciclosporina e azatioprina. Era 2: de 2001 a 2006 (n = 120); associação de ciclosporina e micofenolato e Era 3: de 2007 a 2011 (n = 300); associação de tacrolimus e micofenolato. Resultados:Os resultados mostram aumento da idade média do receptor, da prevalência de diabetes e do número de transplantes com doador falecido (60%) na terceira era. O uso de terapia de indução foi de 75% era atual contra 46,6% (Era 2) e 3,9% (Era 1), p < 0,0001. Os dados de sobrevida geral por tipo de doador mostram dados semelhantes à literatura. Houve progressivo aumento da sobrevida do enxerto com doadores falecidos em 5 anos, saindo de 13,7% (Era 1) para 81,9% (Era 3). Conclusão:Houve significativas diferenças ao longo do tempo, culminando com aumento do volume de transplantes na atual era (média de 14 transplantes/ano na Era 1 para 75 transplantes/ano na Era 3). Inverteu-se o perfil de transplantes na era atual com predomínio de doador falecido. A melhor sobrevida com doador falecido da atual era foi atribuída a maior experiência do centro e aos esquemas de imunossupressão baseados na combinação de tacrolimus com micofenolato associados a esquema de indução.

Controle de doenças fúngicas e de danos por frio em pós-colheita de lima ácida Tahiti

The Tahiti lime appears very susceptible to attack by post-harvest diseases, primarily by the fungi Penicillium and Phomopsis, and also because of its high sensitivity to storage at low temperatures. In order to reduce such damage, the present study aimed to verify the efficiency of heat treatment and disinfection of pathogens in the prevention of post-harvest chilling injury of this cultivar and to compare this treatment with other products using the conventional fungicides. The heat treatments were studied with hot-water temperatures ranging between 48 and 56° C. Water at room temperature was used as a control treatment. After treatment, the fruits were kept under cold temperature at 10° C and RH 90% for about 45 days. For comparison, three other treatments were carried out simultaneously, one using imazalil, one with baking soda, and a third with sodium carbonate, these three products being applied by baths in cold water. Two groups of fruit were evaluated, one treated by immersion considering pathogens coming from the field and another by inoculation with spores of the previously isolated pathogens. For the evaluation of physical and chemical parameters of fruits, determinations were made of the skin color, texture, weight loss, size, juice yield, soluble solids, total acidity and vitamin C content. The determination of the sensitivity of the fruit to cold was made by their exposure at temperatures inducing cold damage. The design was a randomized block design with nine treatments, analyzed by the Statgraphics statistical package. Heat treatments, especially at 52° C, were shown to be more promising in the control of pathogenic fungi and cold damage, surpassing the conventional fungicides. No changes were found in the intrinsic and extrinsic parameters in relation to the application of the different treatments.

Toxicidade do dimetilsulfóxido em cães hígidos e doentes renais crônicos

The objective of this study was to evaluate the effects of dimethyl sulfoxide (DMSO) treatment on aspects of renal function, serum profile, total blood count parameters and clinical condition of health or chronic kidney disease (CKD) dogs. The evaluations were done before, during and after the administration of DMSO 10% at a dose of 0.5g kg-1, each 24h, for three days. DMSO resulted in some adverse effects in both healthy and CKD dogs, however the effects were more frequent and worse in CKD dogs. Despite these adverse effects, both groups don't have contraindications to use the drug in a short time. The severity of adverse effects related to the DMSO and its possible association with death in stage 4 CKD dogs, are contraindications for the drug in this group of patients.

Efeitos da sobrecarga calórica em ratos machos submetidos ou não a restrição protéica in útero

Pós-graduação em Biologia Geral e Aplicada - IBB

Estudo dos mecanismos de ação de leveduras envolvidos no biocontrole de doenças de pós-colheita em citros

Pós-graduação em Microbiologia Agropecuária - FCAV

Doenças infecciosas em crianças pré-escolares brasileiras assistidas em creches

The scope of this article is to analyze the prevalence and factors associated with the development of infectious diseases that affect children in daycare centers, namely respiratory infections, diarrheal disease and parasitic infections. Bibliographic research was conducted in the MEDLINE, LILACS and SciELO databases, and observational studies were included. 129 studies were identified, of which 21 were considered relevant to this study, namely two longitudinal and 19 cross-sectional studies. The systematization of the reviewed studies highlighted: i) the presence of intestinal parasites was the main outcome analyzed, followed by respiratory infections; ii) only one study investigated the occurrence of diarrheal disease; iii) the Giardia lamblia was the most prevalent parasitosis; iv) the variables that were most often associated with the development of intestinal parasitosis were child age, family income and maternal education; v) the attendance at daycare centers was a risk factor for intestinal parasites and respiratory infections. Respiratory and parasitic infections are major problems in institutionalized children in daycare centers. The reduction of such diseases involves a complex web of socio-economic, sanitation and daycare center infrastructure aspects.

Associação entre exposição ao material particulado e internações por doenças respiratórias em crianças

The aim of this study was to estimate the association between exposure to particulate matter less than 2.5 microns in diameter and hospitalization for respiratory diseases. It was an ecological time series study with daily indicators of hospitalization for respiratory diseases in children up to 10 years, living in Piracicaba, SP, Southeastern Brazil, between August 1, 2011 and July 31, 2012. We used generalized additive model for the Poisson regression. The relative risks were RR = 1.008; 95%CI 1.001; 1.016 for lag 1 and RR = 1.009; 95%CI 1.001; 1.017 for lag 3. The increment of 10 mu g/m(3) in particulate matter less than 2.5 microns in diameter implies increase in relative risk between 7.9 and 8.6 percentage points. In conclusion, exposure to particulate matter less than 2.5 microns in diameter was associated with hospitalization for respiratory diseases in children.

Extratos padronizados para o tratamento de doenças crônicas: Serjania marginata Casar. (Sapindaceae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeitos da Reeducação Postural Global na Hipercifose e nas Variáveis Respiratórias de Idosos Relato de Dois Casos

Examine the effects Global Postural Reeducation, (GPR) in hyperkyphosis and respiratory variables in the elderly was the objective in the research. For this, two elderly participated, one is 62 years old (voluntary 1) and another is 66 years old (voluntary 2), without lung, heart, kidney and/or skeletal-muscle diseases diagnosed. The volunteer have been assessed for Quality of Life (QOL) through the questionnaire SF-36, the degree of toracic kyphosis, the muscular respiratory strength and the thoracic-abdominal mobility. The GRP treatment consisted in eight sessions applied, once one hour each session. After the eight sessions the volunteer were reevaluated. The data concerning assessments before and after treatment were analysed describly. According to the results there was an improvement in the degree of kyphosis in both volunteers, highlighting voluntary 2. Respiratory variables also improvements after treatment. In relation to the Quality of life in most areas there has been an increase in scores indicating improved QOL. These data showed that the GPR has been effective to decrease the level of kyphosis, improves respiratory variables and the quality of life in the elderly treated. However, further work with a greater number of subjects must be carried out to analyze the effectiveness of therapy in the elderly.

Efeitos da exposição aos poluentes do ar com base nas internações por doenças cardiovasculares e respiratórias no município de Taubaté, SP

Pós-graduação em Engenharia Civil e Ambiental - FEB

Tendência de mortalidade de idosos por doenças crônicas no município de Marília-SP, Brasil: 1998 a 2000 e 2005 a 2007

OBJECTIVE: to describe elderly mortality from cardiovascular and respiratory diseases and neoplasms in Marilia (SP). METHODS: this is a descriptive study of mortality from three diseases as defined by the 10th International Classification of Diseases, between 1998-2000 and 2005-2007. Mortality Information System records were used. Mortality rates by age and sex were calculated. RESULTS: circulatory diseases were the main causes of death among the elderly (39.25%). Neoplasm decline was noticed in both sexes and in those aged 60-69, particularly prostate cancer in men (-83.86%) and breast cancer (-70.96%) in this age group. Deaths from respiratory diseases increased in patients aged 80 and older: 39.31% in men and 57.92% in women. CONCLUSION: mortality from circulatory diseases and neoplasms among the elderly showed a decline, with increased mortality from respiratory system problems in patients 80 years of age and older.