A rare non-Robertsonian translocation involving chromosomes 15 and 21

CONTEXTO:Translocações robertsonianas (TR) estão entre os rearranjos estruturais balanceados mais comuns em humanos e compreendem a fusão da cromatina completa do braço longo de dois cromossomos acrocêntricos. No entanto, são raras as translocações não Robertsonianas envolvendo esses cromossomos.RELATO DE CASO:Nós descrevemos uma translocação não balanceada de novo envolvendo os cromossomos 15 e 21. A recém-nascida era filha de uma mãe de 29 anos e de um pai de 42 anos, casal não consanguíneo. Os achados clínicos levaram ao diagnóstico de síndrome de Down (SD) com defeitos cardíacos congênitos graves (persistência do canal arterial e defeito do septo atrioventricular completo), além de baixos comprimento e peso ao nascimento (< 5o e < 10o percentil em curvas de medidas específicas para SD, respectivamente). A análise citogenética convencional revelou o cariótipo 46,XX,der(15)(15pter→15q26.2

Mandibular growth and dentoalveolar development in the treatment of Class II, division 1, malocclusion using Balters Bionator according to the skeletal maturation

OBJECTIVE: The purpose of the study was to evaluate the influence of the skeletal maturation in the mandibular and dentoalveolar growth and development during the Class II, division 1, malocclusion correction with Balters bionator. METHODS: Three groups of children with Class II, division 1, malocclusion were evaluated. Two of them were treated for one year with the bionator of Balters appliance in different skeletal ages (Group 1: 6 children, 7 to 8 years old and Group 2: 10 children, 9 to 10 years old) and the other one was followed without treatment (Control Group: 7 children, 8 to 9 years old). Lateral 45 degree cephalometric radiographs were used for the evaluation of the mandibular growth and dentoalveolar development. Tantalum metallic implants were used as fixed and stable references for radiograph superimposition and data acquisition. Student's t test was used in the statistical analysis of the displacement of the points in the condyle, ramus, mandibular base and dental points. Analysis of variance one-fixed criteria was used to evaluate group differences (95% of level of significance). RESULTS: The intragroup evaluation showed that all groups present significant skeletal growth for all points analyzed (1.2 to 3.7 mm), but in an intergroup comparison, the increment of the mandibular growth in the condyle, ramus and mandibular base were not statically different. For the dentoalveolar modifications, the less mature children showed greater labial inclination of the lower incisors (1.86 mm) and the most mature children showed greater first permanent molar extrusion (4.8 mm).

Vitamina D em mulhers adultas fumantes e ex-fumantes: ingestão, concentração sérica e associação com variáveis ecocardiográficas

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Espécies de Meloidogyne Goeldi em cafeeiro no município de Araguari-MG

Pós-graduação em Agronomia (Entomologia Agrícola) - FCAV

Influência do estado nutricional e da composição corporal na evolução clínica dos pacientes com doença inflamatória intestinal

Pós-graduação em Fisiopatologia em Clínica Médica - FMB

Estudo comparativo in vitro da resistência ao cisalhamento de sistemas adesivos em dentina humana: uso de hipoclorito de sódio em sistemas convencionais ou primers acidificados

Pós-graduação em Odontologia Restauradora - ICT

Concepção morfológica de fórceps, para intervenção no paciente em posição supina e o operador sentado

Ergonomics, the science of working rationalization, seeks the best relationship between man and his working tools. In Dentistry, ergonomics is present as for the professional working correctly seated, in functional comfort, intervening of supine position patient, by means of suitable equipment and instrument. Nowadays, dental equipment is justly rationalized; however, some instruments should take shape, in order to adapt those requirements. The hand tool design should permit a comfortable, non-slip and safe handling. Thus, anatomical details, the correct position of the operator for its use and specific characteristics of application should be taken into account. The instrument under analysis - forceps - was conceived according to these requirements along with a new alveolar tooth extraction technique, based on electromyographic and biomechanical studies. The morphology of the instrument, which makes possible a simple and natural kinetics of the operator, was obtained by changing the paradigm of the conventional cross-action instruments (whose grip is always on the arms of the tool), divesting the handle from the tool arm. This induced on anatomical conceiving of perpendicular handles to the extremity of the tool arm, resulting an efficient and effective instrument, according to indicated on its experimental phase

Short-term changes in handgrip strength, body composition, and lymphedema induced by breast cancer surgery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeitos de estado nutricional, da capacidade funcional e do estresse oxidativo em idosos residentes na cidade de Botucatu, SP, Brasil: um estudo longitudinal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A função do coordenador de área no Programa Além das Palavras

Pós-graduação em Educação Escolar - FCLAR

Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Comportamento dos músculos estabilizadores da escápula durante rotação de ombro em indivíduos com síndrome do impacto

Devido à grande diversidade de problemas no ombro e da alta incidência da Síndrome do Impacto (SI) torna-se de grande interesse e importância para a reabilitação o comportamento dos músculos da cintura escapular. O objetivo deste estudo foi analisar a ação simultânea dos músculos serrátil anterior e trapézio durante o movimento de rotação do braço na SI. Participaram do estudo 8 indivíduos com SI unilateral, e 8 indivíduos saudáveis, de ambos os sexos, constituindo 3 grupos: Grupo saúdavel (G1-S), Grupo com SI lado acometido (G2-LA) e Grupo com SI lado não acometido (G2-LNA). Este estudo comparou a atividade eletromiográfica dos músculos estabilizadores da escápula durante os movimentos de rotação interna (RI) e rotação externa (RE), por meio de parâmetros que quantificam a co-contração dos pares de músculos TA/TT, TA/TD, TA/SA, TT/TD, TT/SA, TD/SA, normalizados pela CIVM do movimento de RI e RE dos músculos trapézio ascendente (TA), trapézio transverso (TT), trapézio descendente (TD) e serrátil anterior (SA) entre os voluntários com SI unilateral grau I ou II e indivíduos assintomáticos. Os resultados encontrados para a co-contração dos pares de músculos TA/TT, TA/SA, TT/SA e TD/SA do grupo G2 – LA é maior que dos grupos G1 e G2 - LNA no movimento de RE. No movimento de RI não foi observada diferença que fosse decorrente da SI entre os pares musculares. Como os ombros acometidos pela SI apresentaram co-contração dos pares de músculos significativamente maior durante todo o movimento de RE, o exame da cintura escapular na prescrição de tratamento para SI parece ser aspecto importante para ser considerado, tanto na abordagem desses indivíduos quanto no estudo dos fatores etiológicos e de evolução da SI grau I ou II

Efeito protetor após sessões de exercício excêntrico: comparação entre membros superiores e inferiores

The objective of the present study was to compare in which part (lower limb or upper limb) the repeated bout effect has the greatest magnitude. Twelve males individuals with no recent (6 months) experience with resisted training participated in this study. The subjects were randomly divided into two groups (legs and arms) and came to the laboratory 5 times. 1st) adaptation to the dynamometer. 2nd) to perform one bout of eccentric exercise (EE) and provide markers such as isometric peak torque (IPT), delayed onset muscle soreness (DOMS) (both collected before and after the bout) and concentration of the creatine kinase (CK) enzyme in the blood (only before the bout). 3rd) 48 after the first bout the same markers were collected again. After 14 days, the methodologies used in the 2nd and 3rd visits to the laboratory were repeated respectively to determine the repeated bout effect. A significant decrease of IPT and a significant increase of CK and DOMS were found immediately after and 48 hours after the first bout of EE for the arms group. The legs group showed a significant increase in CK (48 hours after the EE) and DOMS (immediately after the EE) resulting from the first bout. In the arms group, the second bout did not cause significant increase in CK or DOMS on any of the situations, however, it provoked a decrease in force production immediately after the EE. The legs group showed a significant increase of DOMS immediately after the second bout of EE, which caused no significant increase in CK. The only marker in which the repeated bout effect happened for both groups was CK. No significant difference was found between the protections for both groups. Taking into account the results, it’s been discussed whether there is a relation between the susceptibility to muscle damage and the repeated bout effect, and also...(Complete abstract click electronic access below)

Correlação entre aneuploidia cromossômica em espermatozóides e taxa de implantação embrionária: subtitulo

Infertility is directly related to chromosomal abnormalities in germ cells. Among them, the aneuploidies are the most frequent chromosomal abnormalities and responsible for embryo implantation failures, miscarriages, fetal losses and newborns with congenital malformations, mental disability and neuropsychomotor developmental delay. Male patients with normal somatic karyotype may present different rates of aneuploidies in sperm, resulting in abnormal embryos. This study aimed to correlate the frequency of chromosomal aneuploidies in spermatozoa with embryo implantation rate in couples undergoing assisted reproductive techniques. The methodology has included chromosomal analysis by GTG banding and molecular cytogenetic study using Fluorescent In Situ Hybridization technique for evaluation of chromosomes 9, X and Y in germ cells of 22 patients referred to the Human Reproduction Service of the Clinical Hospital FMRP-USP. Embryo implantation rates were determined by hormonal evaluation in maternal peripheral blood and ultrasound confirmation. Two patients presented abnormal karyotype, characterized by polymorphism of the heterochromatic region of the long arm of chromosome 9 and a satellite in the short arm of chromosome 22. Both alterations, usually considered variants of normality, have been related to infertility phenotype and miscarriages. Significant differences were detected between couples who presented pregnancy (group 1) and couples with embryo implantation failure (group 2), with higher frequency of aneusomy and diploidy of chromosome 9, as well as total aneuploidy in sperm of group 2 patients. Our results suggest a correlation between aneuploidy and embryo implantation rates, since the infertile group with reproductive failure has showed higher frequency of aneuploidy. Screening for aneuploidies detection in male germ cells should be included in order to decrease embryo implantation failures, miscarriages and fetuses with chromosomal ...

Indicadores Antropométricos do Estado Nutricional de Idosas Praticantes e Não Praticantes de Exercício Fisíco na Zona Norte de São José do Rio Preto-SP

Although the regular practice of physical exercise for the maintenance of the nutritional state and quality of life is important, it is not a common habit among the elderly, especially those of the lower income social bracket. The objective was to characterize and compare according to social-economic conditions and anthropometric indexes of the nutritional state of the elderly who regularly practice and those who do not practice exercises, offered at no cost, in the Northern zone of São José do Rio Preto-SP. In this study, 110 elderly women participated, of which 60 (group P) exercised regularly and 50 did not (group NP). Group P participated in a special gym program, free of charge, for at least 2 years, 2 to 3 times a week, one hour a day. Group NP was recruited from the same location as Group P. The comparison between the groups of elderly women was proportionately distributed according to marital status, level of education, means of locomotion, results of body mass index (IMC), waist to hip ratio (RCQ) and calf circumference, using the chi-square test. Comparisons were also made of average age, per capita family income, individual income, IMC, arm and triceps skin fold measured by t-Test. Differences were not found in all the comparisons made. The variables that stood out were the IMC (overweight) and RCQ (risk of chronic diseases) results, which were above what was expected, and the high frequency of walking and riding buses for both groups of elderly women (about 60%). We came to the conclusion that the low-intensity exercise program evaluated made no difference in the nutritional profile of the elderly who also used walking as a means of getting around.