Avaliação do desenvolvimento do sistema genital e da funçao reprodutiva da prole feminina de ratos Wistar expostos à cisplatina durante a peri-puberdade

Pós-graduação em Biologia Geral e Aplicada - IBB

Treinamento individualizado aeróbio, resistido e concorrente: efeitos sobre os marcadores de estresse oxidativo em ratos Wistar

Pós-graduação em Ciências da Motricidade - IBRC

Influência da fixação e de métodos de secagem na detecção de alterações proliferativas ultraestruturais induzidas pelo Diuron no urotélio vesical de ratos wistar

Pós-graduação em Patologia - FMB

Avaliação do ecossistema microbiano de ratos wistar submetidos à carcinogênese química de cólon após o consumo de lactobacillus acidophilus crl 1014 e extrato aquoso

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A high-fat diet increases interleukin-3 and granulocyte colony-stimulating factor production by bone marrow cells and triggers bone marrow hyperplasia and neutrophilia in wistar rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Hepatoprotective Effect of Arctium lappa Root Extract on Cadmium Toxicity in Adult Wistar Rats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A new experimental model of cigarette smoke-induced emphysema in Wistar rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Neonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Concurrent training effect on muscle fibers in Wistar rats

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Quantificação de citocinas no soro e homogenato da pata na intoxicação experimental com veneno de Bothropoides jararaca em ratos Wistar tratados com soroterapia e Mikania glomerata

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of autohemotherapy on hematological responses in Wistar female rats Autohemotherapy in rats

Introduction: Autohemotherapy is a type of treatment that have acquired an opposite role and have presented its efficiency strived by the medical community for many reasons. In this study we aimed to evaluate the effects of authohaemotherapy on hematological response. Method: We used Wistar female rats (300g). The study consisted in a control group and a treatment group, blood samples were collected at the first day and at the eighth day after the application. In the both groups we collected 300 μl of blood from each rat through a syringe with a previously prepared solution of 30 μl of sodium citrate 3.2%. In the autohemotherapy group the blood sample was immediately injected in the quadriceps muscle on the back of the thigh hind limb. Rats from the control group did not receive intramuscular blood application. The cellular count was done through flow cytometry and the samples were dosed for immunoglobulin. Results: In the both groups we observed increased production of erytrocites, hemoglobin and platelet (p<0.05). However, there was reduction of basophil in the control group and reduction of lymphocyte, monocyte and neutrophil in the both groups. No effects were observed in IgA, IgG and IgM levels. Conclusion: Autohemotherapy did not influence hematological responses in Wistar female rats.

Cardiovascular Responses Induced by Catalase Inhibitior into the Fourth Cerebral Ventricle is Changed in Wistar Rats Exposed to Sidestream Cigarette Smoke

Objectives: This experimental study aimed to evaluate the effects of central catalase inhibition on cardiovascular responses in rats exposed to sidestream cigarette smoke (SSCS) for 3 weeks. Methodology: A total of 20 males Wistar rats (320–370g) were implanted with a stainless steel guide cannula into the fourth cerebral ventricle (4thV). Femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. Rats were exposed to SSCS for three weeks, 180 minutes per day, 5 days/week [carbon monoxide (CO): 100–300 ppm)]. Baroreflex was tested with one pressor dose of phenylephrine (PHE, 8 μg/kg, bolus) and one depressor dose of sodium nitroprusside (SNP, 50 μg/kg, bolus). Cardiovascular responses were evaluated before and 15 minutes after 3-amino-1, 2, 4-triazole (ATZ, catalase inhibitor, 0.001g/100μL) injection into the 4th V. Results: Vehicle treatment into the 4th V did not change cardiovascular responses. Central catalase inhibition increased tachycardic peak, attenuated bradycardic peak and reduced HR range at 15 minutes, increased MAP at 5, 15 and 30 min and increased HR at 5 and 15 min. In rats exposed to SSCS, central ATZ increased basal MAP after 5 min and increased HR at 5, 15 and 30 minutes, respectively, and attenuated bradycardic peak at 15 minutes. Conclusion: This study suggests that brain oxidative stress caused by SSCS influences autonomic regulation of the cardiovascular system.

Influência da infecção endodôntica associada ou não à diabetes nos níveis da citocina pró-inflamatória IL-17 nos tecidos periapical, hepático e renal de ratos Wistar

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo dos mecanismos envolvidos no processo de diferenciação em linhagem osteogênica de células-tronco mesenquimais da medula óssea de ratos Wistar e ratos espontaneamente hipertensos (SHR)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)