Uso na modulação dos sistemas colinérgico e/ou serotonérgico e/ou gabaérgico de vertebrados, de um extrato bruto vegetal padronizado, composição farmacêutica para o tratamento de disturbios associados a disfunções do sistema colinérgico e/ou serotonérgico e/ou gabaérgico, e processo de produção de medicamento para a modulação dos sistemas colinérgico e/ou serotonérgico e/ou gabaérgico de vertebrados

The present invention provides the use of molecules for cholinergic serotonergic and/or gabaergic system models, revealing pharmaceutical compositions comprising 11-OH-erythravine, erythravine, erythrartine, pharmaceutically acceptable isotherals, salts, byproducts and/or solvates thereof, optionally containing other Erythrine byproducts, for the treatment of anxiety disorders; processes for obtaining said pharmaceutical compositions...

Utilização de fermento de descarte da indústria cervejeira na produção da aguardente de liquor de laranja

Utilização de fermento de descarte da indústria cervejeira na produção da aguardente de liquor de laranja. A indústria de suco de laranja produz ao final do processo um subproduto denominado "liquor" de laranja, que é gerado na operação de prensagem do bagaço, e após concentrado, é adicionado ao farelo de polpa cítrica peletizado (CPP) para a elaboração de ração animal. A indústria brasileira de cerveja, por sua vez, tem descartado anualmente cerca de 160 milhões de litros de fermento, ainda com boa viabilidade (com um percentual de células mortas inferior a 5%). A cerveja mais difundida no mercado brasileiro é a do tipo "larger", produzida por cepas S. uvarum, que são caracterizadas pela baixa fermentação e normalmente utilizadas no máximo de 4 a 10 gerações.

Process for genetically engineering acidophilic bacteria and constructing a transformation vector

The present invention describes a method for transforming chemolithotrophic acidophilic bacteria using electroporation technology. The proposed method allows transforming a bacterial line using a transformation vector, the pAF vector, which contains an origin of vegetative replication that allows the vector to replicate inside the bacteria without altering the natural physiological functions of the latter. Also disclosed is the use of the bacteria modified according to the invention in bioleaching processes of sulphated copper, gold, uranium, nickel, zinc and cobalt ore, inter alia.

Oxoisoaporphine nanocapsules for treating depression

Oxoisoaporphine nanocapsules for treating depression. Nanocapsule systems are described that incorporate compounds of formula I or II that allow controlled, timed release of said compounds. Also described are the production method, the pharmaceutical compositions and the use for preparing a drug.

Piperidinium derivatives including spectaline and cassine derivatives, pharmaceutic compositions containing the same and preparation process

Disclosed are compounds of formulae (II) and (III), wherein R1 is other than hydrogen and the remaining substituents are as defined in the specification, processes for their preparation and pharmaceutical compositions containing them. The compounds are capable of inhibiting acetylcholinesterase, and are useful in the treatment of pathologies associated with cholinergic transmission, such as memory related disorders, neurodegenerative disorders such as Alzheimer's Disease, Myasthenia Gravis and intoxication induced by chemical agents.

Processes for the preparation of piperidinic derivatives and pharmaceutic compositions containing the same

Production processes for preparing pharmaceutical compositions containing new molecules capable of inhibiting acetylcholinesterase, thus being useful in the treatment of pathologies associated to cholinergic transmission, such as memory related disorders, neurodegenerative disorders such as Alzheimer's Disease, Miastenia Gravis or in the treatment of intoxications induced by chemical agents of central action.

Standardized plant extract, method for preparing an extract from plants of the Sclerolobium Genus, cosmetic composition, pharmaceutical composition and use of said extract

Extracts of plants of the Sclerolobium genus are disclosed, as well as methods for preparing same and cosmetic and pharmaceutical formulations containing these extracts. These extracts can be obtained by polar and/or apolar extraction, each fraction containing different anti-oxidants, all of which are useful for topical treatment. Also disclosed is the use of this extract in cosmetic and/or pharmaceutical formulations for topical use.

Methods for obtaining reabsorbable composites, composites, membrane, scaffold and its uses

The present invention relates to novel methods of obtaining reabsorbable composites, based on bacterial cellulose and collagen, for application in tissue repairing Additionally, the present invention relates to the composites obtained by the methods described herein and their uses.

An electrode and use thereof

The application relates to an electrode for use in the electrochemical detection of a target species, wherein the electrode has a planar surface disposed on which are probe molecules that are capable of binding selectively to the target species, wherein the electrode, prior to binding of the probe molecules with the target species, has an electron transfer resistance per area of the electrode of from 10 megaohms cm-2 to 95 megaohms cm-2.

Electrochemical detection method

Electrochemical detection method and related aspects Herein is disclosed an electrochemical test method comprising (i) comparing how a plurality of immittance functions and/or components thereof vary with a change in a parameter of interest for a first system, and then selecting an immittance function or component thereof for use in an electrochemical test; (ii) carryingout an electrochemical test step for a second system to determine at least one value for the immittance function or component thereof selected in step (i), and then, by using a quantitative relationship between the selected immittance function and the parameter of interest, determining a value in the parameter of interest. A computer program and apparatus are also disclosed herein.

Análise comparativa de diferentes metodologias para cultivo de células-tronco mesenquimais derivadas de tecido muscular

Pós-graduação em Biociências - FCLAS

Análise granulométrica do compósito cimentício produzido com adição de resíduos de madeira e escória

Since the early twenty-first century, the construction sector has been the second largest on the rise in the Brazilian industrial sector, with a growth of 1.4% in 2012, and is likely to remain at this level for a long time. However, unlike decades ago, the industry has been seeking in its manufacturing process, sustainable materials, encompassing in their works the concept of sustainability. Thus, the timber sector seeks to satisfy a market increasingly demanding, innovating techniques and utilization being less aggressive to the environment. The purpose of this study was to produce and evaluate the mechanical strength of the composite cement with the addition of wood residues and slag low oven. Therefore, it was made 42 specimen cement-slag-wood, carried out in two steps. Since at the first, it was varied only the slag particle size, and at the second, through the best result of the previous step, it was varied the wood particles granulometry. The mechanical performance of the composite was evaluated by the results obtained in the compression test and the physical test for determining the density of the material. In the first step of the process can be concluded that the best result was achieved with the use of slag particles retained on the 60 mesh sieve. In the second phase of the study concluded that the best results were achieved with wood particles with the large particles, i.e. particles retained on the 10 mesh sieve. Both in the first and in the second step it can be seen that there has been the influence of the particle size of the waste materials. With the obtained results, could be evaluated that the use of waste for the production of cement-slag-wood composite showed lower performance when compared to the results obtained in studies without the use of waste. However, some applications are feasible to be performed with the use of composite wood-cement-slag

O ensino da metodologia projetual no desenvolvimento de produtos de moda: um estudo de caso na Universidade Estadual de Londrina

Pós-graduação em Design - FAAC

Avaliação de cenários para a gestão dos resíduos domiciliares na região norte do Vale do Paraíba/SP

Pós-graduação em Engenharia de Produção - FEB

Estudos sobre a utilização de pentóxido de nióbio nanoestruturado na produção de biodiesel

In heterogeneous catalysis, numerous elements such as titanium and iron have been studied as nanoscale catalysts, but little is known about the use of niobium in nanocatalysis. The nanostructured particles have intrinsic and different physicochemical characteristics with great potential for use in industrial scale. Brazil having the largest known worldwide niobium reserve has the great challenge of creating pioneering technologies with the metal. Biodiesel is an alternative fuel and renewable substitute for regular diesel. Being biodegradable, non-toxic and have CO2 emissions lower than regular diesel, it contributes to the environment and to the independence from oil. The aim of this work was initially synthesize nanoscale particles of niobium pentoxide (Nanospheres, nanorods, nanofibers, nanocubes) from the sol-gel technique. The characterization of different nanoscale structures obtained was performed using different analytical techniques such as x-ray diffraction (XRD) and Scanning Electron Microscopy (SEM). The synthesized nanometer niobium oxide will be used as a heterogeneous catalyst in biodiesel synthesis from commercial soybean oil, checking in detail what the effect of morphology is presented (Nanospheres, nanorods, nanofibers, nanocubes) in the yield of biodiesel synthesis, comparing these results with those already described in literature for the amorphous niobium oxide and other oxide catalysts. The biodiesel obtained was characterized by gas chromatography system equipped with a FID detector