Estudos estruturais e cristalização de complexos formados entre toxinas botrópicas e inibidores vegetais

This research presents a study of structural complexes formed between the bothropstoxin BthTX-I and PrTX-I and phospholipase A2 (PLA2s) inhibitor 12- methoxy-4-methyl-voachalotine (MMV) of Tabernamontana catharinensis and rosmarinic acid (Cv-RA) of Rosmarinus officinalis. For both were used cocrystallization experiments with the toxins and inhibitors. In the future, the experimental three-dimensional structures of these complexes will be obtained through the technique of crystallography. Simultaneously, construction occurred in silico of inhibitors Cv-RA and MMV and attempts of docking between these binders and protein structures. These theoretical data provide important information regarding the nature of interactions between inhibitors, toxins and structural changes induced by the protein molecule inhibitors. Therefore, the acquisition of this information has great value to identification, characterization and development (drug design) of compounds with great potential for biotechnology and drug use. Considering further and more relevant aplications, these compounds could be used to control symptoms in many cases of ophidic poisoning and also in combating of pathological processes (degenerative inflammatory diseases and auto-immune diseases, Alzheimer's disease, schizophrenia, among others) whose causes are related to molecules belonging to the same groups of proteins which are classified bothropstoxin that were studied in this project

Impactos e características nos projetos hidrelétricos Sul-americanos: o caso de Inambari no Peru, o investimento brasileiro e a lei de consulta prévia, 2006-2011

Esta pesquisa trata de um grande projeto hidrelétrico, Inambari, que estava se transformando em realidade como parte de acordos entre o governo do Brasil no segúndo período de Lula (2006-2010) e do governo peruano de Alan Garcia – AG (2006-2011). Inambari é um dos mais recentes projetos hidrelétricos peruanos feitos para exportar ao Brasil. Mas, apesar de formar parte de um acordo entre esses países, por agora está detido devido a protestos e mobilizações da população dos territ´porios de Inambari contra a política hegemônica de AG. Analogamente ao caso da estrada Interoceãnica Sul, a construção e operação da Usina Inambari pode ser entendida como um caso emblemático no cenário Latino Americano atual. Esta não seria apenas o maior projeto hidrelétrico da amazônia peruana, custando aproximadamente 4 bilhões de dolares e prometendo um potencial de geração de energia elétrica de cerca de 2.200 MW para exportar ao Brasil por ano, mas também concretizaria o vínculo energético estratégico entre estes dois países através de um complexo de usinas e linhas de transmissão interconectados. Para sua concretização se conta com o amparo financeiro e legislativo dos dois governos e suas instituições de fomento, além de instituições de internacionais de investimento (como o BID e o BM) e do capital internacional (este útlimo proveniente principalmente de empreiteiras brasileiras beneficiárias do modelo de concessões federais). Aqui se estudam os potenciais impactos na economia amazônica do modelo vigente de exploração de recursos naturais hídricos amazônicos através do caso INAMBARI. A conclusão aponta que inexistência de participação popular como o maior entrave ao desenvolvimento amazônico e tenta explicar a novaconfiguração dos movimentos sociais que buscam voz para os povos da Amazônia bem como o pioneirismo peruano em relação a lei de consulta prévia

Os professores e o consumo de projetos que chegam à escola: o caso do Projeto Lego Education

O estudo proposto focaliza o modo como os professores recebem, consomem e se apropriam de projetos educativos que são implementados nas escolas de ensino fundamental. Trata-se de um estudo de caso que focaliza a implementação, iniciada em 2008, do Projeto Lego Education em escolas de uma rede municipal de ensino no interior paulista. A implementação do referido projeto insere-se em um contexto mais amplo marcado pelo crescimento de um “rentável mercado formativo” (Nóvoa, 1999) entre nós atualmente. Diante desse contexto, surge uma questão: Como foi, para os professores daquela rede de ensino, a inserção do Projeto Lego Education em seu trabalho docente e como os mesmos lidam com o projeto atualmente? Para tentar responder a essa questão o presente estudo foi realizado com os professores que foram capacitados e atuaram na implementação do projeto, a partir de entrevistas semi-estruturadas e observações. Objetivou-se investigar como o referido projeto foi apropriado (de Certeau, 1994) pelos professores na sua implementação e como os mesmos percebem o projeto atualmente. Pretendeu-se identificar, assim, maneiras pelas quais os professores relacionam-se com materiais didáticos, livros/guias do professor e cursos de capacitação docente ligados ao Projeto Lego Education, procurando caracterizar as maneiras como os mesmos se apropriam e consomem (de Certeau, 1994) tais produtos que lhes são dirigidos. Nesse estudo foi realizada também a análise de documentos relacionados ao Projeto Lego Education (sites das empresas envolvidas, manuais e revistas, entre outros materiais), focando em como esses materiais se referem ao professor e sua prática em sala de aula. A inserção nas escolas públicas de projetos que, como o LEGO, são provenientes de empresas privadas, aponta... (Resumo completo, clicar acesso eletrônico abaixo)

Abordagem scrum de gerenciamento ágil para desenvolvimento de novos produtos aplicada a área de ensaios de uma fabricante de aeronaves

There are many approaches and techniques about Administration and Management of Projects in order to provide greater agility, efficiency and transparency during the development process of new products. Simultaneously, a pursuit for a management approach more flexible in its planning and strategic changes during the development campaign, such as, comprehend the project's unpredictability level and deal it by monitoring and estimates tools. These features tend to accentuate itself in manufacturers of complex products, as aircraft and other aerospace technologies. By these conditions thus research aims to describe a case when the Agile Management Processing of Project Development Scrum was used in the Test area of an aircraft manufacturer. Focused on the Scrum implementation over the area, its adaptation, evolution and achievements the research proposes to analyze the improvements, indicate the obstacles and discuss solutions, contributing then to the theoretical basis of the considered theme and futures updates applicable to the area. The research is classified as qualitative; furthermore the information and data analyzed were obtained by interviews with professionals and observations of the processes from the major aircraft manufacturer

Estudo da utilização do balanced scorecard na gestão da qualidade e excelência operacional aplicadas a projetos de engenharia em sistemas de potência

The expansion of the electrical system is currently a subject of great importance to the development of Brazil. For its realization, large projects are needed, requiring large-scale investment and realization processes of great complexity. Thus, this type of project has a high strategic importance for the performance of companies that conduct. Seeking a way to determine a method to align traditional practices for measuring quality to the corporate strategic needs, this work is the study of the use of the balanced scorecard methodology, applying quality management and operational excellence, with a focus on projects in power systems. We analyzed some cases of successful application of the methodology in business segments in the next study, culminating in a proposed model of the method

Determinação de complexos de urânio em solo usando a técnica de difusão em filmes finos por gradiente de concentração (DGT)

This paper proposes to assess the lability of complexes of uranium in soil using the technique of Diffusion in Thin Films by concentration gradients (DGT) in the vicinity the Osamu Utsumi mine, located in the municipality of Caldas - MG. The technique is based on the 1ª Fick Law, where metal complexes diffuse through a gel, which in turn is adsorbed on a resin. The metals adsorbed are recovered by an analytical technique and quantified by optical emission spectrometer with plasma inductively coupled (ICP-OES) or mass spectrometry with inductively coupled plasma (ICP-MS)

PGCP - Plataforma para Gerenciamento Colaborativo de Projetos

Collaborative Systems are designed to support individuals in order to solve a problem together, or cooperatively (or collaboratively). Such systems have the advantage of not requiring the presence in the same location of the participants. The basis of any Collaborative System is communication, where users interact with each other in order to exchange information. Communication among individuals is accomplished through collaborative tools such as chat, email, document repository, etc.. Using these tools, companies can reduce operational costs, saving on travel and accommodation of its employees to attend meetings. The project members only need a computer with internet access to use collaborative tools. Project management is essential to the quality of the nal product. To perform a proper management, methodologies must be applied using methods, tools and procedures. There are some phases that are considered generic for all software process models, they are: de nition, development, maintenance and activity to support the software process. In this paper is described a platform for project management using the concepts and features of Collaborative Systems. The goal of this platform is to unify various collaborative tools (such as chat and document repository) in a project management system. Using the system, it becomes possible to manage projects, and the ability to maintain an active constant communication between members of each project

Proposta de um processo de categorização de fornecedores para a execução de projetos

Nowadays, in business environment, organizations seek to differentiate through special programs and plans, taking the concepts of sustainability, performance and benefits generated for society. Based in this competitive environment, as companies depend on the use of subcontractors to perform services for your different customers, the work performed by them is directly related to the vision created by the final customer’s vision of the company responsible for the project. Considering that the supplier hired to execute the project does not share the strategic concepts related to the level of services to be offered to the final customers, thus creating the need to develop methods that enable the alignment between the project owner, responsible for preparing the executive project, and the supplier, responsible for the execution of the work. Tangent to this need, it was necessary to create a method of evaluation and categorization for suppliers to hired for the projects. As a result it has been proposed a process of categorization of suppliers, through the restriction of possible companies to be hired for a project designed to promote alignment between strategies and continuous improvement of the solutions offered to the market

Sistema Gerenciador de Projetos PROEX

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Estudo, desenvolvimento e concepção de uma célula de carga

In engineering projects, it’s fundamental to determine the active loads in components in order to guarantee acceptable values of safety and reliability according to project specifications. On the other hand, force measurement methods might be very complex and impracticable in some cases and, so that, load cells with eletric resistance strain gages can be applied as a simple and accurate option to measure the required load. The main purpose of this paper is to present the development of a load cell that measures uniaxial forces using electric resistance strain gages without being influenced by the location of the loading in a cantilever beam. For that, it was taken as basis a secondary purpose which is to present a general study of basic and wide concepts about transducers, load cells and extensometers primarily. Information such as: loading and measurements types, characteristics of the presented devices as well as factors that influence its functioning, the most common kinds of Wheatstone bridge links, the main points of a load cell project, cements used to fix extensometers and, finally, the project itself with the tests of the built transducer are presented. By the end of this paper, all the results are shown and analyzed, concluding about the designed load cell and the work itself

Mapeamento geológico e petrologia dos complexos máfico-ultramáficos de Mangabal Sul e Mangabal Norte, região de Sanclerlândia, Goiás

The Mangabal Sul and Mangabal Norte mafic-ultramafic complexes are interpreted as intrusive stratiform bodies in the Goiás Magmatic Arc during the Brazilian cycle, being economically important for harboring significant amounts of nickel and copper sulfides. The main lithotypes of the complexes are gabbronorites, olivine gabbronorites, pyroxenites and peridotites, with variated degrees of deformation, recrystallization and metamorphism superimposed, with metamorphic peak of amphibolite to granulite facies evidenced mainly by the occurrence of coronitic olivine in metamafic rocks and the occurrence of syn-kinematic retrometamorphism associated with the development of the main foliation Sn. The Sn foliation planes show NE-SW preferential direction, consistent with the foliation direction of VIII the enclosing gneisses and schists, also concordant with the general elongation of mafic and ultramafic bodies displayed on map. The sulfide phase presents textures that indicate remobilization, associated with the occurrence of significant amounts of rutile within the ore which reinforces this idea. Along with the sulfides, the occurrence of expressive quantities of titanium oxides such as ilmenite and rutile, make the area more economically attractive. It can be suggested that the Mangabal Norte and Mangabal Sul complexes are contemporary, have the same genetic affinity and suffered the same deformational and metamorphic processes, evidenced by their structural and petrological similarities

Análise dos problemas de comunicação permeados pela cultura organizacional e estrutura de gestão de projetos em uma empresa na área da construção

In a supplier of building products were identified difficulties in communication between the Product Development area and other areas of the company that could spoil projects and processes. The process of product development is important in placing the company in the market, and through research and planning, design new products and seek to comply with the costumer in relation to deadlines, quality and cost-effective. The development of a product involves many areas in the company and communication is essential in this process. The goal of this study was to identify possible communication problems permeated by organizational culture and structure of project management working in the company. A survey was applied using a Likert scale in three different areas of the company, with questions including the topics: communication, culture and organizational structure of project management and subsequently conducted the median test and the Spearman test to analysis of responses. With the understanding and analysis of the survey it was confirmed the difficulties of communication between people and the areas of the company, besides there is an influence of the type of culture acting in the company and the current management structure of the project in a good performance of internal communication

Um estudo de novos paradigmas na realização de projetos de instalação elétrica residencial (automação)

Through awareness of new trends of consumption of the population with regard to housing, comfort, entertainment, security and sustainability, it was crafted a work that set out to study and develop the concept of home automation and how it will revolutionize the electrical installation projects and energy savings. A pre-wiring project, taking into account, basically, the installed load, is presented as a basis for comparison. The protocols for communication between intelligent devices in an automation environment, used in the work, are the X-10, LonWorks and UPnP. The home network is studied and divided into subsystems, for a better understanding, which are the lighting, audio, video and multimedia system, security, air conditioning and central vacuum system, and the idea of integrated design and system integrator is introduced, showing the change necessity in the design philosophy of electrical installations. The main means of energy savings in an automated home, such as dimerization, master off and smart meters are presented and, finally, it was concluded that there is a need to structure electrical installation projects more comprehensive with regard to home automation, in order to become more efficient and useful to users

Estudo comparativo de modelos matemáticos de qualidade de águas superficiais

Surface water quality models have been developed since 1925, when Streeter e Phelps created first order equations that represent the balance between DO and BOD. Since then, and specially after the ‘60s, new computational technologies evolved, making it possible to create more complex models, which try to represent, through mathematics, natural phenomena like eutrophication and rivers self-depuration. As main objective of such models is the understanding of aquatic systems and the relationship between them and the environment, so that it can support decision makers in creating water manage plans and in elaborating environmental projects of such resources. Regarding to that, it is of crucial importance the understanding of the models structures, so that one can choose the most appropriate model for the river in question. While one-dimensional models like QUAL2K are more appropriate for long and narrow rivers, bi- or tridimensional models (CE-QUAL-W2, WASP and CEQUAL- ICM) are more commonly used in wide and slower rivers, with higher lateral and/or vertical mixes rates. Besides, the more complex is the river studied more complex the model should be, which demands more costs and time for the model to be applied

A participação social através do crowdfunding: uma análise dos projetos da plataforma catarse

This study examined the practices of crowdfunding, collective vehicle of fundraising for the production of works of culture, education, social programs etc over the internet. Through the analysis of registered projects and finalized in Brazilian site funding col-laborative Catarse, we were able to list interesting points to be considered to deter-mine what lead people to cooperate or not with this kind of practice. It was noticed that the internet materialized in front of individuals as an important vehicle for social participation, enabling the concern to collaborate on projects, people and causes that have common characteristics or interests bring benefits to society