Papel das proteínas Nod na modulação da resposta imune nas doenças priodontais

Pós-graduação em Odontologia - FOAR

Extratos padronizados para o tratamento de doenças crônicas: Arrabidaea spp

Pós-graduação em Química - IQ

Doenças sexualmente transmissíveis e hepatite C em idosos do município de Botucatu-SP

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Derivados ftalimídicos de compostos antiinflamatórios não-esteróide e/ou moduladores de TNF-(alfa), processo de sua obtenção, composições farmacêuticas contendo os mesmos e seus usos no tratamento de doenças inflamatórias

The present invention relates to phthalimide derivatives of non-steroidal and/or TNF-+- modulating anti-inflammatory compounds as well as the process of obtaining the so-called derivatives, pharmaceutical compositions containing such derivatives and their uses, including use in the treatment of inflammatory diseases, especially those related to chronic inflammatory processes, such as rheumatoid arthritis and intestinal inflammatory diseases (for instance, Chron's disease) and the use of the referred to pharmaceutical compositions as antipyretic, analgesic and platelet antiaggregating medications.

Processo de obtenção de compostos derivados de anti-inflamatários esteráides (aies), composições farmacêuticas contendo tais compostos e seus usos no tratamento de doenças de caráter inflamatário

A presente invenção se refere ao processo de obtenção de compostos derivados de anti-inflamatórios esteróides (AIEs) e de talidomida com propriedades anti-inflamatórias, analgésicas e imunossupressoras úteis no tratamento de processos inflamatórios. A presente invenção se refere também as composições farmacêuticas contendo tais compostos e seus usos na fabricação de medicamentos para o tratamento de doenças inflamatórias principalmente aquelas relacionadas a processos inflamatórios crônicos.

Uso de compostos derivados ftalimídicos e/ou sulfonamídicos no tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-alfa e a necessidade de uma fonte exógena de óxido nítrico, compostos derivados ftalimídicos, compostos derivados sulfonamídicos, método de obtenção de um composto derivado sulfonamídico

A presente invenção se refere ao uso de compostos derivados ftalimídicos e/ou sulfonamídicos com propriedades doadoras de óxido nítrico, os quais apresentam importantes atividades no aumento da expressão gênica de gama globina e atividades antiinflamatórias e analgésicas, potenciais ao tratamento de doenças hematológicas em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico. Mais particularmente, a presente invenção descreve o uso de tais derivados ftalimídicos e/ou sulfonamídicos para o tratamento de anemia falciforme. A invenção também apresenta como característica inovadora, a descrição de novos derivados ftalimídicos funcionalizados, desenhados a partir dos protótipos talidomida e hidroxiuréia e planejados racionalmente através da estratégia de hibridação molecular para o tratamento das doenças citadas. A invenção apresenta ainda um novo método de obtenção de um derivado sulfonamídico específico que pode ser utilizado na preparação de um medicamento para tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico.

Uso de compostos derivados ftalimidicos e/ou sulfonamídicos no tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-alpha e a necessidade de uma fonte exógena de óxido nítrico, compostos derivados sulfonamídicos. Método de obtenção de um composto derivado sulfonamídico

Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-[alpha] levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.

Controle de doenças fúngicas e de danos por frio em pós-colheita de lima ácida Tahiti

The Tahiti lime appears very susceptible to attack by post-harvest diseases, primarily by the fungi Penicillium and Phomopsis, and also because of its high sensitivity to storage at low temperatures. In order to reduce such damage, the present study aimed to verify the efficiency of heat treatment and disinfection of pathogens in the prevention of post-harvest chilling injury of this cultivar and to compare this treatment with other products using the conventional fungicides. The heat treatments were studied with hot-water temperatures ranging between 48 and 56° C. Water at room temperature was used as a control treatment. After treatment, the fruits were kept under cold temperature at 10° C and RH 90% for about 45 days. For comparison, three other treatments were carried out simultaneously, one using imazalil, one with baking soda, and a third with sodium carbonate, these three products being applied by baths in cold water. Two groups of fruit were evaluated, one treated by immersion considering pathogens coming from the field and another by inoculation with spores of the previously isolated pathogens. For the evaluation of physical and chemical parameters of fruits, determinations were made of the skin color, texture, weight loss, size, juice yield, soluble solids, total acidity and vitamin C content. The determination of the sensitivity of the fruit to cold was made by their exposure at temperatures inducing cold damage. The design was a randomized block design with nine treatments, analyzed by the Statgraphics statistical package. Heat treatments, especially at 52° C, were shown to be more promising in the control of pathogenic fungi and cold damage, surpassing the conventional fungicides. No changes were found in the intrinsic and extrinsic parameters in relation to the application of the different treatments.

Substituição da farinha de peixe por farinha de vísceras de aves na alimentação do piavuçu Leporinus macrocephalus

The present study aimed at evaluating the productive performance of Leporinus macrocephalus fed with different levels of inclusion of poultry viscera meal replacing fish meal. The experiment was conducted in a stove located in the Universidade Estadual do Oeste do Paraná during 45 days. We used 200 fish with average initial length of 4.7 ± 0.37 cm and average initial weight of 1.407 ± 0.03 g, distributed in 20 net-cages. The experimental design was randomized with five treatments and five replicates with five levels of replacement of fish meal by poultry viscera meal (0, 25, 50, 75, 100%). The parameters evaluated were the productive performance and the chemical composition of animals. The inclusion of poultry viscera meal in the substitution of fish meal in the feeding of Leporinus macrocephalus can be used without impairing the performance of the animals.

Community ecology of metazoan parasites of the sairú Cyphocharax nagelii from the Peixe River

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pesque-solte: pesca repetitiva, variáveis hematológicas e parasitismo no peixe híbrido tambacu

The objective of this work was to evaluate the hematological and parasitological responses of tambacu (Colossoma macropomum x Piaractus mesopotamicus) subjected to catch-and-release stress and to different stocking densities in a catch-and-release system. Two hundred and ten fish with mean initial weight of 785.33±152.02 g and mean total length of 34.43±2.21 cm were maintained in ponds and divided into three groups: without fishing and low density (G1), with fishing and low density (G2), and with fishing and high density (G3). No significant differences were observed between the mean values for hemoglobin concentration, erythrocyte number, differential counting of leukocytes, and glucose. The fish from the G3 group showed higher parasite and thrombocyte numbers, and lower weight gain and hematocrit. The activity of catch-and-release, associated with high stocking density, can disrupt organic balance and animal performance, favoring parasitosis.

Potencial de óleos essenciais de plantas para o tratamento de enfermidade em peixes

Pós-graduação em Aquicultura - FCAV

Estudo dos mecanismos de ação de leveduras envolvidos no biocontrole de doenças de pós-colheita em citros

Pós-graduação em Microbiologia Agropecuária - FCAV

Doenças infecciosas em crianças pré-escolares brasileiras assistidas em creches

The scope of this article is to analyze the prevalence and factors associated with the development of infectious diseases that affect children in daycare centers, namely respiratory infections, diarrheal disease and parasitic infections. Bibliographic research was conducted in the MEDLINE, LILACS and SciELO databases, and observational studies were included. 129 studies were identified, of which 21 were considered relevant to this study, namely two longitudinal and 19 cross-sectional studies. The systematization of the reviewed studies highlighted: i) the presence of intestinal parasites was the main outcome analyzed, followed by respiratory infections; ii) only one study investigated the occurrence of diarrheal disease; iii) the Giardia lamblia was the most prevalent parasitosis; iv) the variables that were most often associated with the development of intestinal parasitosis were child age, family income and maternal education; v) the attendance at daycare centers was a risk factor for intestinal parasites and respiratory infections. Respiratory and parasitic infections are major problems in institutionalized children in daycare centers. The reduction of such diseases involves a complex web of socio-economic, sanitation and daycare center infrastructure aspects.

Associação entre exposição ao material particulado e internações por doenças respiratórias em crianças

The aim of this study was to estimate the association between exposure to particulate matter less than 2.5 microns in diameter and hospitalization for respiratory diseases. It was an ecological time series study with daily indicators of hospitalization for respiratory diseases in children up to 10 years, living in Piracicaba, SP, Southeastern Brazil, between August 1, 2011 and July 31, 2012. We used generalized additive model for the Poisson regression. The relative risks were RR = 1.008; 95%CI 1.001; 1.016 for lag 1 and RR = 1.009; 95%CI 1.001; 1.017 for lag 3. The increment of 10 mu g/m(3) in particulate matter less than 2.5 microns in diameter implies increase in relative risk between 7.9 and 8.6 percentage points. In conclusion, exposure to particulate matter less than 2.5 microns in diameter was associated with hospitalization for respiratory diseases in children.