212 resultados para Padrão esquelético
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There are substantial evidences that the period experienced by humanity globally is unprecedented and is heading towards a major transformation that results from the Globalization. Totally conditioned to the addictions of the dominant and predatory capitalism, humanity has, for decades, exhausted natural resources, disregarded the nature of its own social existence and walked away from its humanity. It is notable, however, an impressive flow of factors that dialogue and support each other as trends that go towards sustainable development, based on the harmonious integration between Technology, Culture, Society, Environment and Economy. This emerging moment can be seen from the perspectives of the Creative Economy as economic paradigm centered on the subjectivity and the human capacity to undertake innovative services, products and solutions guided by social values. Within this fluid and dynamic global context, initiatives that legitimately intend to act sustainably are gaining space. This socioeconomic moment fosters and is fostered by new kinds of work and organization guided by the Collaboration and social structuring on Network Patterns. These new social models significantly transform the understanding and insights about the Communication flows. The HUB São Paulo, as creative and social organization that operates under the logic of Collaboration through a Network Structure, was the subject of a case study used to sustain the defense of this emerging scenario and also to perform an analysis on the new role of Communication, at perspectives of transformation of mental paradigms towards sustainability and establishment of meaningful connections
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Recent research advances in understanding the cellular and molecular mechanisms that underlie the processes of hypertrophy and atrophy. This may contribute to development of effective therapeutic strategies to attenuate or block the loss of muscle tissue associated with aging and pathological conditions. In this context, myogenic factors that control the activity of satellite cells have been studied to better understand the events involved in the recovery of muscle mass. Among them, we highlight the Myogenic Regulatory Factors (MRFs), which have been described as potential mediators of muscle growth. The objectives of this study evaluated the morphofunctional adaptations and gene expression of MRFs (MyoD and myogenin) in skeletal muscle (soleus) subjected to an atrophic stimulus followed by physical training. It was used 64 male Wistar rats (80 days, 250 to 300 g), divided into 8 groups (n = 8): C: control animals a week, I: Animals immobilized a week, C3: control animals 3 days; R3: Animals immobilized and recovered for 3 days, T3: Animals immobilized and submitted to exercise for 3 days; C7: Animals controls 7 days; R7: Animals immobilized and subsequently recovered by 7 days, T7: Animals immobilized and subsequently subjected to exercise for 7 days. Initially, the animals in groups I, R3, R7, T3 and T7, were submitted to 7 days of immobilization of the hind limb. Muscle atrophy was confirmed after a direct statistical comparison of the values of cross-sectional area (CSA) of muscle fibers studied in animals in groups I and C, sacrificed immediately after the immobilization period. Then, the groups T3 and T7 were submitted a rehabilitation program with muscle aerobic exercise (swimming) for 3 and 7 days respectively. The groups C, C3 and C7 were kept without stimulus atrophic and were not subjected to exercise. At the end of the experiment, the animals were sacrified and the soleus muscle removed. The quantitative analysis of gene expression ...
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Nowadays, there is a need for improvements in production processes for companies to be competitive, as it is an obligation of businesses, it is necessary to know about the production processes accurately, to learn where improvements in work and thus have large impacts results. The calculation of efficiency of production lines is necessary to know as much about the progress of production and for product costing, when the measurement is not suitable, it generates negative impacts on the company. Due to the impact generated by this parameter, the graduation work carry out the study of change in a method that does not include all requirements necessary, by another method known as Overall Equipment Effectiveness, and according to studies, covering various parameters, showing become more consistent. These values are contained in the pattern production which is used to fund the product, thereby also occur financial impacts. Thus the work will study the change along with the analysis of impacts caused by the change
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Os morcegos estão constantemente expostos a condições ambientais que podem alterar o seu padrão de atividade. No presente trabalho descrevemos a atividade horária de morcegos filostomídeos em três áreas florestais no sudeste do Brasil. Também testamos a influência da temperatura ambiente, luminosidade da lua e de diferentes áreas na atividade de Carollia perspicillata. Foram coletados 154 indivíduos pertencentes à família Phyllostomidae, sendo 37,7% deles representados por C. perspicillata (n = 60). Glossophaga soricina, Sturnira lilium e Desmodus rotundus apresentaram um padrão unimodal em sua atividade. Já Anoura caudifer, Chrotopterus auritus e Micronicterys microtis demonstraram uniformidade nas capturas ao longo da noite. C. persprcillata apresentou um padrão bimodal, com picos de atividade no início e final da noite, no entanto a espécie foi ativa durante todo o período. Houve diferença na atividade de C. perspicillata entre as áreas, sendo uniformemente distribuída nas áreas I e III, e unimodal na área II. A temperatura ambiente e a luminosidade do luar não foram fatores decisivos na regulação da atividade de C. perspicillata.
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This study focuses on the current use of the relative pronoun qual and variants or alternatives (o/os/a/as/ qual/quais, preceded or not by prepositions) in Brazilian Portuguese concerning mainly on the phenomenon of hypercorrection. As a theoretical basis, it was used the study of William Labov about the phenomenon and also the rules of use of this pronoun present in both traditional grammars and linguistic studies. It was performed a qualitative analysis of a corpus of written language with the intention of describing the different uses of the pronoun, and looking for their possible motivations. There were also found different types of occurrences of hypercorrection, which has led to propose a scale of uses of this relative pronoun, which reveals an increasing loss of its functions towards an use as an index of prestige. It discusses also the stylistic factor as a potential motivator of this phenomenon
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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To determinate the multielemental concentrations in biological samples using the technique of total reflection X-ray fluorescence (TRFX) is essential the use of standard samples. The aim of this study is the determination of the sensitivities of the relevant elements in standard samples (Multi Element atomic spectroscopy standard solution in HNO3 I) prepared in three solutions with different and known concentrations. Based on the sensitivities of the elements contained in the multilelementar standard sample, it can estimate the sensitivity for an element found in the biological sample and consequently it is possible to determinate the concentration, even though the standard does not contain this element. The measurement of fluorescence was performed at the Brazilian Synchrotron Light Laboratory (LNLS) in Campinas
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A insuficiência cardíaca (IC) está associada à miopatia dos músculos esqueléticos com aumento da expressão das isoformas rápidas da cadeia pesada de miosina e alterações na matriz extracelular. Os fatores de regulação miogência(MRF),como a MyoD e MRF4, pertecem a uma família de fatores transcricionais que controlam vários genes músculo-específicos.Esses fatores forma heterodímeros com proteínas HLH e ligam-se a seqüências de DNA conhecidas como Ebox, presentes na região promotora de vários genes músculo–específicos, incluindo todos aqueles que codificam as subunidades dos receptores nicotínicos de acetilcolina (nAChR) da junção neuromuscular (JNM). Baseado no fato de que na IC há uma diminuição na expressão da MyoD e MRF4 no músculo sóleo de ratos com IC induzida por monocrotalina, o objetivo do presente trabalho é verificar possíveis alterações na expressão dos receptores de acetilcolina, bem como realizar uma análise morfológica e morfométrica das JNMs. Neste estudo foram utilizados ratos Wistar, machos, divididos em grupos controle e experimental e a Insuficiência cardíaca (IC) foi induzida pela injeção de monocrotalina intra-peritoneal.Quando os sintomas de IC foram visualizados (após 22 dias) os animais foram sacrificados pentobarbital sódico i.p. (50 mg/Kg). A seguir foram mensurados o peso corporal (PC) dos ratos, bem como outros parâmetros. O músculo sóleo de ambos os antímeros foram dissecados e preparados para: avaliação da expressão gênica das subunidades ε, γ e α dos receptores de acetilcolina por PCR em Tempo Real; para análise morfológica e morfométrica da Junção Neuromuscular através da técnica de Esterase inespecífica; para análise ultra-estrutural da JN. Os resultados indicam que não houveram alterações morfológicas e morfométricas na JN, mas houve um aumento... (Resumo completo, clicar acesso eletrônico abaixo)
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A quantificação de citocinas felinas possibilita uma avaliação do sistema imune do animal em diferentes doenças, permite também a identificação de diferentes fatores que alteram sua secreção, e colabora na compreensão da patogênese das enfermidades. Em humanos e camundongos essa mensuração é feita principalmente pelo método de ELISA, mas para os felinos há uma menor disponibilidade de kits específicos para determinadas citocinas, e estes possuem um custo elevado. Assim, uma alternativa é utilizar a reação de PCR em tempo real com transcrição reversa (RT-qPCR) para quantificação absoluta dos RNAs mensageiros das citocinas felinas, uma técnica bastante sensível e específica para analisar a expressão desses genes. Com esse intuito, esse trabalho teve como objetivo clonar as sequências gênicas codificantes de citocinas, para construir uma curva padrão para a qPCR. Assim, foi feita extração de RNA de amostras de sangue total de gatos domésticos, e estes foram tratados com DNAse para evitar contaminação por DNA genômico. O cDNA foi sintetizado, e amplificado com os primers específicos para cada fragmento codificante de citocina e o GAPDH felino. Cada amplicon purificado foi inserido em um plasmídeo comercial, e introduzido em bactérias E. coli cepa DH5. Os clones recombinantes foram sequenciados para confirmar a inserção do fragmento no vetor. As curvas padrão da qPCR foram construídas com cada plasmídeo recombinante numa de 106 a 101 cópias por reação. O sequenciamento mostrou que todos os clones eram semelhantes àqueles encontrados no GenBank. A eficiência das amplificações, baseado no slope das curvas padrão foram: 101,3% para GAPDH, 99,1% para IL-1, 83,2% para IL-6, 94,4% para IL-10, 105,5% para IL-12, 83,4% para IFN- e 83,8% para TNF-. O valor de r2 foi de 0,99 em todas as reações. Dessa forma, com a clonagem dos fragmentos... (Resumo completo, clicar acesso eletrônico abaixo)
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Appuyé sur le concept de lexiculture, proposé par R. Galisson (2000), et en reconnaissance de l’existence et de la dimension du mouvement Hip Hop en France, le but de cet article est d’examiner l’importance de cette culture et de son lexique dans le contexte français, soulignant aussi la nécessité de son insertion dans les matériels éducatifs destinés à l’enseignement du français langue étrangère (FLE). À cet effet, nous avons elaboré, à l’aide d’un système de traitement de corpus, une liste bilingue français-portugais brésilien de ce lexique, à partir des paroles des trois principaux artistes français. Il faut noter que la plupart de ces unités lexicales ne sont pas présentes dans les dictionnaires généraux bilingues, ce qui crée des difficultés aux apprenants ainsi qu’aux enseignants d’accès à ce lexique, qui coexiste avec la langue standard étudiée et qui représente une grande richesse linguistique.
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Studies have shown that adolescents begin to make use of alcoholic beverages earlier and excessively, a behavior which has several negative consequences. Thus, the present study aims at investigating whether the expectations they have for the effects of alcohol consumption are high or low and if there is a relationship between expectation and consumption pattern. AUDIT and IECPA were applied as data collection instruments. The first indentifies the pattern of alcohol use and the second investigates the expectations the subjects have in relation to the use of alcohol. The results of this study, differently than others, do not evidence the positive relationship between binge-drinking and high expectations about the use of alcohol.
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Pós-graduação em Física - FEG
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Pós-graduação em Engenharia Civil - FEIS
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)