Estratégias tecnológicas para aumento de solubilidade e diminuição de toxicidade do fármaco antifúngico anfotericina B

A Anfotericina B é o fármaco antifúngico referência desde a sua descoberta na década de 50 até os dias atuais para o tratamento de infecções fúngicas sistêmicas. O objetivo do trabalho é realizar uma revisão bibliográfica que forneça os sistemas de liberação comercializados e os que estão em estudo, focando estratégias tecnológicas que possam servir para resolver os problemas da baixa solubilidade em água e da alta nefrotoxicidade da Anfotericina B. A AmB é um fármaco que apresenta inexpressiva solubilidade em meio-aquoso, principalmente na região de pH dos fluídos biológicos (7,4–8,0), sendo administrado atualmente por via endovenosa. Justificando a importância desse estudo para a área farmacêutica, novos sistemas de liberação que usem a via oral, aumentarão a adesão por crianças e idosos, além de aumentar o arsenal terapêutico e diminuir os gastos com hospitalizações. Por ter a sua utilidade clínica limitada em razão de sua alta toxicidade, tem-se buscado direcionar a AmB especificamente para o fungo ou pelo menos para o local da infecção, mantendo-se longe o fármaco das células hospedeiras. Para isso, se busca diferentes veículos que não o desoxicolato (Fungizone). Por fim, as formulações lipídicas mostram-se com maior eficácia e com menor toxicidade comparadas a Anfotericina B-desoxicolato, mas não fazem parte da rotina hospitalar em razão do seu alto custo

Estratégias de enfrentamento de problemas em jovens atletas: um estudo através do EMEP

The study aimed to analyze coping strategies used by Young soccer athletes during the competition period. 172 male soccer athletes of 8 teams participating in Copa São Paulo de Futebol Júnior 2013, aged between 15 and 20 years old, most of high school education took part in the study. As instrument it was used the Brazilian version of the Ways of Coping Scale. Therefore, a contact was made with teams, where they had permission or not to apply and then day and time were scheduled to data collection, this was made in order to preserve the teams performance. Given that, most of the data were collected during the rest period of the teams, that is, when there was a long interval between one match and another. Data analysis was performed using descriptive statistics and frequency through the program Statistical Package for Social Sciences (SPSS) version 17.0 for Windows. The collected data suggests that most athletes use the coping strategy problem-focused, because it had the highest average, while emotion-focused coping strategy was the factor with lowest average. The results indicate that athletes have a higher emotional control and aiming to solving the stressful situation at the own problem

Potencial profilático de estratégias tolerogênicas no diabetes experimental

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estratégias ambientais na indústria automobilística: um estudo de caso na Wolkswagen de São Carlos-SP

This research has as main objective show how the auto industry has been dealing with the environmental factor, more specifically during the production process and the support areas, and how the environmental management system is implemented, the operation and maintenance. Presents a number of actions related to the theme that has been taking by the automakers, as well as a case of the Volkswagen do Brasil engine plant, in São Carlos - SP

Um mundo radicalmente melhor: criatividade, colaboração e padrão de redes como estratégias para o desenvolvimento sustentável

There are substantial evidences that the period experienced by humanity globally is unprecedented and is heading towards a major transformation that results from the Globalization. Totally conditioned to the addictions of the dominant and predatory capitalism, humanity has, for decades, exhausted natural resources, disregarded the nature of its own social existence and walked away from its humanity. It is notable, however, an impressive flow of factors that dialogue and support each other as trends that go towards sustainable development, based on the harmonious integration between Technology, Culture, Society, Environment and Economy. This emerging moment can be seen from the perspectives of the Creative Economy as economic paradigm centered on the subjectivity and the human capacity to undertake innovative services, products and solutions guided by social values. Within this fluid and dynamic global context, initiatives that legitimately intend to act sustainably are gaining space. This socioeconomic moment fosters and is fostered by new kinds of work and organization guided by the Collaboration and social structuring on Network Patterns. These new social models significantly transform the understanding and insights about the Communication flows. The HUB São Paulo, as creative and social organization that operates under the logic of Collaboration through a Network Structure, was the subject of a case study used to sustain the defense of this emerging scenario and also to perform an analysis on the new role of Communication, at perspectives of transformation of mental paradigms towards sustainability and establishment of meaningful connections

Rebranding: propostas de estratégias para a reconstrução de marca no Centro Universitário da FEI

This paper relates the concepts of brand management in the educational context of Brazilian higher education to demonstrate how can we do a reconstruction and the importance of establishing a solid relationship with the public of an organization to become loyal to your brand . The reflections in this project seek to demonstrate how PR professionals can plan the reconstruction process of a brand. To achieve the ultimate goal of the project seeks to introduce the concepts of branding, PR and stakeholders in order to highlight the new challenges that organizations face today. To illustrate the concepts aborted, the procedures suggested for the reconstruction of a brand are used in the case study of the Centro Universitário da FEI. For this, it is a diagnosis of the organization and subsequently suggested a process for strategic rebrading, as well as the association of a brand management with public relations

PARFOR e a formação inicial dos professores: um estudo sobre a confiança, as atitudes e as estratégias em relação à resolução de problemas

The mathematical problem solving is very important in the student's school career, leading him to develop his creativity and self-confidence. The way the teacher explains specific content may interfere in the student learning. Some researches show that the teacher trust and his problem solving rapport lead to a more satisfying job. This research focused on students of the course PARFOR at UNESP Bauru. This work was performed in order to investigate the affinity, trust and attitudes toward mathematical problem solving, the performance from who have positive and negative attitudes and the results that may be generated during class

Etiopatogênia da artrite-encefalite caprina e estratégias para seu controle

The arthritis-encephalitis caprine vírus is found at mostly areas of the world, especially at the countries that milk goats is strongly tecnific, and already was found in many brasilian states. The illness causes greats econimics prejudice, influencing badly the productive life time of the flock, related with the low production, decrease of the reproductive performance and lost of the genetic potential, determining constants flock’s renew. Many authors calls the atention for the probable dissemination of the illness and reinforce the necessity of the adoption strong sanitary politics for the illnes control. The controls programs, basically, based on knowledeg of the target-cells, that keep and distribute the virus on the guests organisms; on the transmition way; on sensibility and specificity of the sorologics tests, as well as your frequency of realitation in the flock; and after all on the management that the flock is submeted

Usos não-padrão das estratégias de relativização no português brasileiro: hipercorreção e estilo

This study focuses on the current use of the relative pronoun qual and variants or alternatives (o/os/a/as/ qual/quais, preceded or not by prepositions) in Brazilian Portuguese concerning mainly on the phenomenon of hypercorrection. As a theoretical basis, it was used the study of William Labov about the phenomenon and also the rules of use of this pronoun present in both traditional grammars and linguistic studies. It was performed a qualitative analysis of a corpus of written language with the intention of describing the different uses of the pronoun, and looking for their possible motivations. There were also found different types of occurrences of hypercorrection, which has led to propose a scale of uses of this relative pronoun, which reveals an increasing loss of its functions towards an use as an index of prestige. It discusses also the stylistic factor as a potential motivator of this phenomenon

Comunicação Organizacional e Mídias Sociais: o uso das redes sociais nas estratégias de comunicação

The growing concern of experts in organizational communication with appropriate business relationships with its various stakeholders through digital platforms causes an upgrowth on the number of studies on the topic of social media. The social network communication receives analysis in different approaches, ranging from behavioral changes to the instrumentalization of these tools for marketing, relationship and information exchange. The objective of this monograph is to make an exploratory study that relates to organizational communication and social media, and discuss how the theories can contribute to the optimization of communication mediated by specific platforms that bring with them opportunities for interaction and relationship in the digital environment

Modelo computacional para a dinâmica de uma bola de vôlei para a definição de estratégias de saque aplicadas

Este trabalho consiste em desenvolver um programa que seja capaz de descrever a trajetória da bola durante o saque de vôlei. Para isso, foram analisadas todas as forças que atuam sobre a bola e com isso montar um sistema de equações. Para que este possa descreva a trajetória percorrida e assim fornecer melhoria para o fundamento prático para a equipe de Vôlei Medley/Campinas

As estratégias governamentais frente à empregabilidade de jovens e adultos: investigando os meandros da relação educação e trabalho

This conclusion of course work aims to investigate the city of Limerick / SP, in order to question whether there are and what public policies developed by local, if there are training places for young people and targeting the job market or even partnerships between the city and local businesses seeking to supply the concrete conditions of preparation and targeting young people for the labor market. All changes in education accompanied the need to provide skilled labor to contribute to the country's economic development. The work is divided into several chapters. The first chapter is about the whole historical development of professional education in Brazil and new challenges. The second chapter discusses the reality of the world of work changes and their consequences, and the issue of working children and adolescents. The third chapter is about the difficulty of insertion of the poor youth in the current job market. The fourth chapter presents the city of Limerick to the needs of professional schools to meet the large number of trades and industries, which are currently listed by the educational institutions of the city and programs signed between the Municipal bodies and institutions such as SENAC (National Service of Commercial Learning) and Senai (National Service of Industrial Learning). The fifth chapter presents an interview with the CAMPL the city of Limerick, whose goal and give professional training to teens to get the first employee. Readings were taken from several authors who treat on the subject

Dificuldades no processo de ensino e aprendizagem de Química: estudo e proposição de estratégias para o ensino médio

This study shows new alternatives to the teaching of chemistry in high school and wants to be an aid to the teacher at the time of the planning of lessons and a way to help students improve their performance in this discipline. The central issue is the exploration of differentiated teaching strategies for a just end: improvement of education in chemistry. To reach the main point is to undertake a survey of the most important issues for students and teachers, and from there many teaching strategies are suggested to help in understanding the contents studied. The idea is to propose strategies that may be of interest to students of chemistry, stimulating the curiosity of wanting to know more about a certain content that is being studied in the classroom. This study shows that chemistry is not boring, is not as difficult as it seems, and everyone can indeed take pleasure in studying a world as real and so fascinating, if you understand the facts

Estratégias de aplicação de softwares educativos como instrumentos para o ensino de física

The technological advances of recent decades combined with digital inc1usion in Brazil sparked the country's population to the constant use of computers to perform tasks in many different natures. Whether it's for communication, entertainment, work or school, computers are tools with increasing numbers in Brazilian homes. Along with this evolution the Brazilian Physics teaching should be aware of the use of teaching tools that relate directly to the computer to student learning. Highlighting in this work we have scanned the contents of the Wikipedia community, a wide variety of educational videos placed on YouTube, educational games that try to teach the player in a fun way and a variety educational softwares placed on the World Wide Web. It is with special attention to educational softwares as tools for teaching physics, which describe some strategies for use of these software, combined with the textbooks, to illustrate some ways to introduce the use of educational softwares directly in the classroom

O uso do material manipulativo Tangram e de jogos como estratégias de motivação para a aprendizagem de frações

In this research, we analyzed the use of manipulative materials and games as motivators tools that facilitate the comprehension of fractions content when presented to a class of students from the 9th grade from a public school in Guaratinguetá-SP city. The students are 14 and 17 years old. Initially we presented the benefits that could bring manipulative materials for teaching and learning with understanding, followed by historical accounts of the Tangram material. We show the advantages of the games, when properly used in activities classroom. The game titled Dominoes fractions using the Tangram was applied in order to check if students retook properly the fractions contents. This research was motivated students to participate in math classes and this motivation may have promoted the understanding of the contents worked