226 resultados para Curvatura da superfície


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Pós-graduação em Enfermagem (mestrado profissional) - FMB

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Odontologia Restauradora - ICT

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Pós-graduação em Odontologia Restauradora - ICT

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Atualmente são conhecidas aproximadamente 10.000 substâncias do metabolismo secundário de invertebrados e microorganismos marinhos. Dentre os organismos marinhos estudados do ponto de vista químico e farmacológico, destacam-se, as esponjas, as ascídias, os briozoários e os octocorais. No entanto, pouco se sabe quanto ao potencial imunomodulador de compostos isolados de microrganismos marinhos, em especial daqueles isolados da costa brasileira. A propriedade anti-inflamatória de diferentes extratos brutos foi inicialmente avaliada pelo potencial destes compostos quanto à inibição da produção de óxido nítrico (NO) em linhagem de macrófagos, RAW 264.7. Posteriormente as amostras que se mostraram promissoras foram também avaliadas em relação ao potencial imunomodulador quanto a expressão de moléculas de superfície relacionadas migração (Mac-1 ou CD11b) e ativação celular (CD80 e CD86) em linhagens de macrófagos estimulados com LPS. Nossos resultados mostram que dentre as 289 amostras testadas apenas o extrato DLM33 e as substâncias Ma(M3%)J-MeOH e Dr(M3%)6-MeOH/H2O foram inicialmente considerados promissores quanto capacidade de inibir a síntese de NO por macrófagos. O extrato DLM33 foi capaz de de modular apenas a porcentagem de macrófagos positivos para CD80 na presença de LPS. No entanto, a substância Dr(M3%)6-MeOH/H2O não se mostrou eficiente quanto a modulação da expressão de moléculas de superfície Mac-1, CD80 e CD86. Surpreendentemente, a substância Ma(M3%)J-MeOH apresentou um potencial imunoestimulador quanto a expressão de Mac-1+/CD80+, mas não de CD86, em macrófagos sugerindo um possível efeito adjuvante desta substância. O efeito imunoestimulador da substância Ma(M3%)J-MeOH será futuramente investigado utilizando diferentes abordagens in vitro e in vivo para validar os resultados obtidos... (Resumo completo, clicar acesso eletrônico abaixo)

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Mesenchymal stem cells (MSCs) are adult multipotent cells with fibroblastoid morphology and adherent to plastic. Furthermore, they can be obtained from different sources. Besides bone marrow, these cells are taken from umbilical cord blood, umbilical vein, saphenous vein, peripheral blood, arteries, liver and fetal pancreas, placenta, dental pulp and adipose tissue. MSCs derived from adipose tissue are important because of the abundant number of cells that can be obtained from this tissue, easy access and little discomfort to the patient. This study compared two techniques for obtaining MSCs from adipose tissue: mechanical dissociation (MD) and enzymatic digestion (ED). We also analyzed the inter-species cross-reactions using commercial monoclonal antibodies directed against surface antigens of stem cells from different species: mouse, horse, rabbit, monkey and human. We found that MD technique is favorable in relation to ED within 15 days of culture, and ED is more efficient in the first days of culture. The data also showed that MD causes less damage to cellular DNA. About inter-species cross-reactions, the monoclonal antibody A69 directed against stem cells from rabbits, which can be used in veterinary medicine, particularly in research involving horses

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This paper presents the study on the application of the electrolytic plasma for surface treatment of aluminum. A bibliographical study on the material of interest was preliminarily performed and later designed and built an electrolytic cell, including the excitation source. Unlike conventional electrolysis process, the plasma assisted carry on in the non-linear region of characteristic current/voltage curve. Therefore it requires for the on set of the process that the power supply operates on harder conditions than those on high current process. The plasma produced during the present investigation has temperatures in the range o 6,0.10 3 -7,0 .10 3 K, well above those found in conventional chemical process. It also shows a particular dynamic to promote changes on surface and to produce new materials. The plasma is generated by microdischarge in vapor or gas bubbles involved in physic-chemical processes in electrode regions of the electrolytic cell. The electrode material was the aluminum (7075). The Process Electrolytic Plasma Processing (EPP) is sensitive to various parameters such as operating voltage, current density, electrolyte, concentration of electrolyte, geometry of reactor, temperature of electrolytic solution and dynamic of the fluid in the cell. The experiments were carried on in order to find parameters for a stable abd steady operation. The choice for the electrolytic was silicate/alkali solution in various concentrations to operate in various voltage as well. Plasma was produced on negative (cathode) and positive (anode) electrode, in specific conditions. A stable operation on the cathode process was obtained with low concentration of the electrolytic in aqueous solution, current density around 250V effective voltage. For the evolution of plasma in anodic process it was required higher concentrations and higher... (Complete abstract click electronic access below)

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In this work, the influence of modifications of the cp-Ti and Ti 6Al 4V alloy, by treating the surface with NaOH and depositing titanium oxide and hydroxyapatite by sol-gel method, on their biocompatibility was studied. The coatings were characterized by scanning electron microscopy and X-ray diffraction which showed that the coatings on Ti 6Al 4V are better than on cp-Ti. Adhesion tests showed that adhesion strength of the coatings on cp-Ti substrate is less than on Ti 6Al 4V as well as cytotoxicity for L929 fibroblast cells is higher

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Fracture surfaces are the fracture process marks, taht it is characterized by energy release guieded by failure mode. The fracture toughness express this energy em stress and strain terms in pre-cracked samples. The strectch zone is the characteristic region forms by the transition of fatigue fracture and final fracture and it width demonstrate the relation with failure energy release.The quantitative fractography is a broadly tool uses in failure surfaces characterization that it can point to a material’s aspect or a fracture process. The image processing works like an investigation tool, guinding a lot of studies in this area. In order to evaluate the characterization effectivity and it respectivity studies, it used 300M steel that it was thermal treated by an aeronautical process known and it characterized by tensile test and energy dispersive spectroscopy (EDS). The tensile test of this material, made by ASTM E8, allowed the head treatment effectivity confirmation, beyond of mechanics porperties determination. The EDS confirmed the material composition, beyond of base the discussion about fracture mechanism presence. The fracture toughness test has also made, that it works to obtain the fracture surfeaces studies below self-similarity and self-affinity approaches. In front of all the exposed it was possible to conclude that the fractal dimension works like a study parameter of fracture process, allowinf the relation of their values with changes in thickness, which interferes directly in material’s behaviour in fracture toughness approach

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To evaluate the effect of surface treatment with Er:YAG and Nd:YAG laser on resin composite bond strength to recently bleached dentin. Material and Methods: In this study 120 bovine incisors were used and distributed into two groups: Group C: without bleaching treatment; Group B: with bleaching treatment (35% hydrogen peroxide). Each group was divided into three subgroups: Subgroup N: without laser treatment; Subgroup Nd: irradiation with Nd:YAG laser; Subgroup Er: irradiation with Er:YAG laser. Next, the adhesive system (Adper Single Bond 2) was applied and composite buildups were constructed with Z350 composite. The teeth were sectioned to obtain dentin-resin sticks (1x1mm) and analyzed by microtensile bond testing. The data were statistically analyzed by the ANOVA and Tukey tests. Results: The results showed that the bond strength values in the bleached control group (16.17 MPa) presented no significant difference in comparison with the group bleached and irradiated with Er:YAG laser (14.69 MPa). The non bleached control group (26.79 MPa) presented significant difference in bond strength when compared with the non bleached group irradiated with Er:YAG laser (22.82 MPa) and with the group treated by bleaching and irradiation with Nd:YAG laser (28,792 MPa). The group without bleaching treatment and irradiated with Nd:YAG (36.1 MPa) presented a significant increase in bond strength in comparison with the other groups. Conclusion: The use of Nd:YAG laser on bleached specimens was able of completely reversing the immediate effects of bleaching, obtaining bond strength values similar to those of the control group