Influência do tratamento fisioterapêutico em grupo no equilíbrio, na mobilidade funcional e na qualidade de vida de pacientes com Parkinson

Introduction: Parkinson’s disease (PD) is a chronic disease of the nervous system, characterized by degeneration of neurons in the mesencephalic substantia nigra, leading to a clinical state of rest tremor, bradykinesia, muscular rigidity and postural instability. Physical therapy seeks to act by slowing the progression of the disease and when done in a group and maintain and / or improving the motor skills of the individual, can provide psychosocial benefi ts. Objective: examine the infl uence of the physical therapy group in balance, functional mobility and quality of life of individuals with PD. Method: participated in this study 04 subjects were female, mean age 67.75 (± 9.5) years, with medical diagnosis of PD, stages 1 to 3 of the Hoehn & Yahr. Before starting treatment, subjects underwent an assessment of the balance (BBS), functional mobility (TUG) and the quality of life (PDQ-39).The treatment was performed in groups, for a period of 10 weeks, lasting 60 minutes each session twice a week, totaling 20 sessions of physiotherapy. Upon completion of the treatment period the subjects were again assessed for balance, functional mobility and quality of life. The data were analyzed using the Student t-test, with signifi cance level of 5% (p ≤ 0.05). Results: statistical analysis showed signifi cant differences in three variables: equilibrium (p = 0.010), functional mobility (p = 0.029) and quality of life (p = 0.004), after physiotherapy intervention. Conclusion: physiotherapy treatment was group provides better balance, functional mobility and quality of life of patients with PD.

Influência do fortalecimento muscular na independência funcional de indivíduos parkinsonianos

Introduction: Parkinson’s disease is a chronic disease of the nervous system that leads to a clinical picture of resting tremor, bradykinesia, muscular rigidity and postural instability. These symptoms, in turn, directly influence the functional independence of the individual. Objective: To analyze the influence of muscle strengthening on functional independence of individuals with Parkinson’s disease. Method: A total of ten subjects of both genders participated in this study. We evaluated the functional independence, strength of lower limbs, grip strength testing and 1 repetition maximum. After the evaluation was performed muscle building program for 12 weeks. Results: There was improvement of functional independence (p = 0.007) and lower limb strength (p = 0.01), as well as an increase in grip strength, both of the dominant hand (p = 0.007) and the non-dominant one (p = 0.02). Conclusion: The muscle strength improved the functional independence of individuals with PD.

Capacidade funcional, declínio cognitivo e depressão em idosos institucionalizados: possibilidade de relações e correlações

This research was aimed to survey depressive episodes, functional and cognitive decline of an elderly population residing nursing homes (NH) located at Marília, São Paulo, Brazil, and, from statistical analysis, verify the potential correlations between depressive episodes, functional and cognitive decline, amongst themselves and with the variables: age, gender and education. There were subject to the research 57 elders living in the NH, aged between 59 and 98 and both sexes. The following tools were used to collect data: Mini Mental State Exam (MMSE) to evaluate cognitive faculty, Barthel Index (BI) to evaluate cognitive faculty and Beck Depression Inventory (BDI).

Equilíbrio funcional em indivíduos com doença de Parkinson e sua relação com a qualidade de vida

Introduction: Parkinson’s Disease (PD) is characterized by a set of four motor symptoms: tremor, rigidity, bradykinesia and postural instability. These defi cits may predispose individuals to limitations resulting from falls and their secondary consequences. Objective: To evaluate the functional balance and quality of life (QoL) in individuals with PD and determine whether there is correlation between performance on tests of balance with the QoL. Method: The project was referred to the Ethics Committee in Research of Universidade Estadual Paulista “Julio de Mesquita Filho” Campus de Marília and was approved under protocol number 1806/09. Participated in this study with individuals diagnosed with PD between levels one and four in the Hoen and Yahr scale. The subjects were evaluated according to functional balance and QoL, respectively by the instruments: Functional Balance Scale Berg (EEFB), Time Up and Go test (TUG), and Parkinson’s Disease Questionnaire-39 (PDQ-39). To perform the statistical analysis used the GraphPad Prism 5. To perform the correlation analysis for the variables passed normality by the Shapiro-Wilk. Since the variables were non-parametric test was used Spearman. During the analysis the statistical signifi cance level was considered p ≤ 0, 05. Results: We studied 25 individuals aged between 54 and 85 years (71.20 ± 8.50), time of diagnosis between one and 39 years (6.54 ± 7.71) disease. Moderate correlation was found between the EEFB with QoL (r =- 0.6), and TUG with QoL (r = 0.6836). Among the aspects of QoL balance showed a higher correlation with the domains “mobility” (TUG r = 0, 6768; EEFB r = -0.6155) and “Activities of daily living” (TUG r = 0, 7357, and EEFB r = -0.6521). Conclusion: Patients with Parkinson’s disease show defi cits in balance and QoL. The balance disorders have a high correlation among themselves and show how aspects of QoL.

Comparação da flexibilidade, qualidade de vida e capacidade funcional entre idosos ativos e sedentários dos meios urbano e rural

Introduction:The regular practice of physical activity is being used as a therapeutic resource to the elderly population, with the objective of reduction of the losses provoked by the growing old process. The home place (urban or rural) is still little explored in literature about your infl uence in the physical capacity of the elderly people. Objective: The aim of this study was to value and compare the quality of life, motion and functional capacity between physically active and sedentary elderly people, residents in the urban and rural area. Methods: Sixty people with age above 60 years old were valued, 20 physically active residents in the urban area (66,5 ± 4,32 years), 20 sedentary residents in the urban area (68,8± 7,24 years), 10 physically active residents in the rural area (64,4±2,46 years) and 10 sedentary residents in the rural area (68±5,78 years). It was realized the evaluation of the fl exibility (previous fl exon of the trunk), mobility (timed up and go test), a six-minute walk test and answered a quality of life’s questionnaire SF-36. To compare the results obtained by the two groups was used the Kruskal-Wallis test, and the signifi cant presence of the test was performed post hoc Newman-Keuls. The level of signifi cance used in statistical analysis was 5% (p<0,05).Results: It was observed that the physically active elderly people obtaine better performance on the six-minutes walk test. It wasn’t found difference in the mobility among the groups. In relation to the quality of life, the elderly residents in the rural area, were better in the component Vitally. In relation to the fl exibility the elderly residents in the urban area obtained the best results. So, we can conclude that the practice of physical activity realized by the volunteers contributed to a better functional capacity, observed by the biggest distance gone through on the walk test. The rural home place positively infl uenced the vitality control, while the fl exibility was worse presented in these elderly people.

Eficácia de mobiliário escolar adaptado de baixo custo no desempenho funcional de criança com paralisia cerebral

Indivíduos com Paralisia Cerebral apresentam desenvolvimento motor atípico, caracterizado por alterações posturais, de coordenação motora e de tônus muscular, que resulta em limitações no desempenho de atividades funcionais. Neste contexto destaca-se a prescrição e confecção de recursos de tecnologia assistiva com objetivo de maximizar as habilidades funcionais destas pessoas e prover sua inclusão social. Os indivíduos com paralisia cerebral, muitas vezes, têm dificuldade para a manutenção da dinâmica corporal, principalmente na postura sentada. O objetivo deste estudo foi o de confeccionar uma cadeira e mesa escolar adaptadas com material de baixo custo e verificar sua eficácia no desempenho grafomotor de uma criança com paralisia cerebral. O participante foi uma criança com diagnóstico de paralisia cerebral diplégica, do gênero masculino. A coleta e registro dos dados foram feitos em três momentos, com a criança posicionada no mobiliário adaptado, no mobiliário escolar comum e novamente no mobiliário adaptado, para se estabelecer a comparação. A análise de dados se deu por meio de testes estatísticos não paramétricos. Não houve significância estatística e foi verificada uma inconstância nos dados apresentados, já que não se pode afirmar ao certo qual mobiliário foi mais eficaz na realização da atividade proposta e nem se houve aprendizado motor com a sua repetição. Esse fato não invalida a adequação de mobiliário escolar ao aluno com paralisia cerebral, visto que este é um fator importante para favorecer o controle e estabilidade postural ao individuo, o que interfere na coordenação motora fina destes indivíduos, influenciando no seu desempenho em atividades escolares.

A Arquivística Funcional e sua contribuição para o desenvolvimento de uma disciplina contemporânea

Nos últimos vinte anos, as novas formas de produção documental e as tecnologias de informação têm levado os arquivistas a repensarem seu papel na sociedade, assim como os princípios e conceitos arquivísticos promulgados no século XIX. Neste contexto, emergem, notadamente no Canadá, novas abordagens para a organização do conhecimento arquivístico contemporâneo, destacando-se, dentre elas, a Arquivística Funcional, ou Pós-Moderna. O presente artigo aborda a contribuição dessa nova corrente para a constituição de uma disciplina contemporânea, notadamente a partir dos estudos de seu precursor e disseminador, Terry Cook.

Efeitos de estado nutricional, da capacidade funcional e do estresse oxidativo em idosos residentes na cidade de Botucatu, SP, Brasil: um estudo longitudinal

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Descrição léxico-gramatical e funcional dos verbos pronominais do português brasileiro com vistas ao aperfeiçoamento da base de verbos da wordnet brasileira e do alinhamento semântico desta à base de verbos da wordnet norte-americana

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Análise funcional do gene da proteína 14-3-3 de Paracoccidioides brasiliensis

A paracoccidioidomicose (PCM) é micose profunda causada pelo fungo dimórfico Paracoccidioides brasiliensis (Pb), endêmica na América Latina, principalmente no Brasil. A capacidade de P. brasiliensis de não só provocar doença humana, mas também de causar micose com grande variedade de manifestações clínicas, desde formas localizadas até doença disseminada, evoluindo para letalidade, depende provavelmente da virulência do fungo, da habilidade deste em interagir com as estruturas superficiais do hospedeiro e invadi-las, e da resposta imunológica deste último. O sucesso da colonização dos tecidos do hospedeiro pelo fungo é um evento complexo, geralmente envolvendo um ligante codificado pelo patógeno (adesinas) e um receptor da célula. Uma adesina de 30 kDa de P. brasiliensis, ligante de laminina, foi caracterizada através de seqüenciamento de aminoácidos, mostrando que esta é uma proteína 14-3-3 envolvida na adesão deste fungo às células epiteliais. Estas formam uma família de proteínas diméricas, ácidas e estão presentes em múltiplas isoformas em muitos organismos eucariotos. Com o intuito de se estudar sua funcionalidade em P. brasiliensis, pretendeu-se clonar, caracterizar e utilizar como hospedeiro do gene desta proteína a levedura Saccharomyces cerevisiae. Para tanto, as seqüências gênicas da adesina 14-3-3 de isolados de P. brasiliensis obtida pela clonagem do cDNA em vetores bacterianos foram utilizadas para obtenção de um homólogo funcional em S. cerevisiae. A capacidade do gene da 14-3-3 de P. brasiliensis ser um homólogo funcional, aderir e invadir as células epiteliais tratadas deve ser avaliada utilizando o modelo pré-existente de culturas celulares in vitro de linhagens humanas. Assim, neste estudo além da clonagem, expressão da 14-3-3 de Pb e obtenção do homólogo funcional do gene desta proteína em S. cerevisiae, foi iniciada... (Resumo completo, clicar acesso eletrônico abaixo)

Estudos estruturais por difração de raios X de fosfolipases A2 em presença de íons com importância funcional

Snakes from Bothrops genus are responsible for more than 90% of the ophidian accidents in Brazil. One of the main complications from this kind of accident is muscular necrosis, which is related to the action of phospholipases A2 and metalloproteases, two groups of enzymes found in the venom of these animals. Although this complication cannot be solved by serum therapy administration, a great number of studies have been performed with the attempt to know the pharmacological sites of these toxins aiming, in the future, the development of complementary treatments to serum therapy. This work proposes structural studies of bothropic phospholipases A2 (PLA2s) in the presence of ions relevant to their activity, using the X-ray crystallography technique. Recently, it was demonstrated ions, as manganese, calcium and others, interfere in the biological activity of the PLA2s. Particularly, Lys49-PLA2s in the presence of manganese ions have miotoxicity reduced. Asp49-PLA2s show catalytic activity dependent of calcium, although structural studies with a miotoxic Asp49-PLA2, BthTX-II, suggest a possible catalytic mechanism independent of calcium. Therefore, co-crystallization of BthTX-II in the presence of calcium ions and of PrTX-I in the presence of manganese ions were performed. Comparative structural studies among obtained results and others already published in the literature were performed aiming a better understanding of the structure-function relationship of these toxins. The BthTX-II with the presence of calcium do not show this ion in the loop of coordination of calcium, presence necessary to develop the catalyses. After comparison of this model with the native one, only one distortion was found, but no apparent relationship with the residues responsible for its activity. In the PrTX-I structure, regions candidates of manganese ions were also found... (Complete abstract click electronic access below)

Análise de atividade epileptiforme com uso simultâneo de eletrencefalografia e ressonância magnética funcional

The use of multimodal neuroimaging techniques has been helpful in the investigation of epileptogenic zone in patients with refractory epilepsies. This work aims to describe an ictal event during EEG-fMRI performed simultaneously in a 39-year-old man with refractory epilepsy. The EEG data were recorded at a sampling rate of 5 kHz, using a BrainAmp (BrainProducts, München, Germany) amplifier, with 64 MR (magnetic resonance) compatible Ag/AgCl electrodes. MR images were acquired using a 3T scanner in 3 sequences of 6 minutes of echo-planar images (EPIs), with TR = 2s, being the last sequence stopped after the ictal event. The EEG was corrected for gradient and pulse artifacts using the Brain Vision Analyzer2 software (BrainProducts), and the functional images were realigned, slice-timing corrected, normalized and smoothed. The start of the ictal changes was used for the evaluation of the BOLD response in MR images, using a t-test with a minimum cluster of 5 voxels, p <0.005 (T>2.5). The patient had a partial complex seizure, as noted by neurologist. The fMRI data showed positive BOLD responses (activation) in dysplastic areas, but showed the most significant activation outside the lesion, in areas compatible with secondary spread of the epileptic focus, probably caused by motor reaction also observed during the seizure. As a conclusion, we note that the technique of EEG-fMRI can detect the epileptogenic zone in patients with refractory epilepsy, but areas of dissemination of primary epileptogenic focus may show significant activation, introducing additional difficulties to the interpretation of the results

Avaliação do potencial de sistemas nanoestruturados estabilizados com poliéter funcional siloxano para administração tópica de metotrexato

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

A aglomeração urbana de Piracicaba: uma análise da integração funcional entre os municípios sob a ótica do movimento pendular

The growth area of cities has resulted in a phenomenon of conurbation (or expressing tendency). This correspond to a combine of two or more urban cores, there are formations of conurbations. In this way, there are the formations of urban concentrations and can achieve the step metropolitan or not metropolitan. Besides, this kind of expansion generates many social and environmental problems related about habitation, rubbish, drain, and others. Piracicaba, a city in expansion, recently, shows evidences of conurbation not metropolitan around itself. Like this, the paulista government, at June, 26 of 2012, institutionalized the Urban Concentration of Piracicaba, a regional unity, intending the administration along with 22 cities. However, for this fact, must be taken into account functional integration among urban centers, because the number of municipalities are presented to compose a urban concentration of level not metropolitan. It has checked along this research, according with proposition about 22 cities. Thus, the objective of this research is identify and analyze the functional integration among participating municipalities through the commuting, in other words, the spatial displacement of people, important factor to be taken into account when defining urban concentration. Considering the displacement routine people, the commuting, also aimed identify the flow of public transport intercity travel among the cities of Piracicaba Regional Unity. Then, analyze the criteria used for establish the Piracicaba Regional Unity, if it was considered technical character or if it was prioritized the political character. To conduct this research, it was done the literature review related to the theme and data collection related lines of intercity transportation and often travel with ARTESP and companies responsible for it service