Efeito citotóxico de agentes clareadores a base de peróxido de hidrogênio a 20% e 38% sobre células odontoblastóides

The aim of this in vitro study was to evaluate the trans-enamel and transdentinal cytotoxic effects of two in-office tooth bleaching techniques that employ bleaching gels containing 20% and 38% of H2 O2 on cultured odontoblast-like cell line (MDPC-23). Sixty enamel/dentin discs were obtained from bovine central incisors and placed individually in artificial pulp chambers. Six groups were formed according to the following enamel treatments: G1- 20% H2 O2 (1 application); G2- 20% H2 O2 (2 applications); G3- 38% H2 O2 (1 application); G4- 38% H2 O2 (2 applications); G5- 38% H2 O2 (3 applications); and G6- control (no treatment). In G1 and G2, the bleaching gel was left in contact with the enamel surface for 45 min in each application. However, in G3, G4, and G5 the bleaching gel was applied for only 10 min per application. After the last application, the extracts were collected and applied on previously cultured cells (30.000 cells/cm2 ) for 24 h. Cell metabolism was evaluated by the MTT assay and cell morphology was analysed by scanning electron microscopy. Cell metabolism decreased by 96.29%; 96.11%; 96.42%; 95.62%; and 97.18% in G1, G2, G3, G4, and G5, respectively. All treated groups differed significantly from non-treated control group (G6) (p < 0.05). However, the difference in cell metabolism among treated groups was not significant statistically. In addition, significant morphological cell alterations were observed in all treated groups. Under the tested experimental conditions, the extracts collected after both tooth bleaching techniques evaluated in this study caused severe toxic effects on cultured odontoblast-like cell MDPC-23.

Estudio descriptivo in vitro de dos agentes blanqueadores de distinta concentración sobre la micromorfología del esmalte bovino

Dental tooth bleaching is a conservative option for the treatment of tooth stains. It is based on the use of hydrogen peroxide as an active agent. Despite its effectiveness to lighten tooth colour, there is concern regarding its use due to the effects it could have over enamel surface. There is scarce evidence on the subject and contradictions exist between different authors. The aim of this study was to compare enamel surface micromorphology after bleaching teeth with different concentrations of hydrogen peroxide solutions. Method: 50 healthy bovine incisors sectioned horizontally at the cemento-enamel junction were prepared. Contents of pulp chamber and tooth surfaces were cleaned. The buccal surface of each tooth was divided vertically, assigning one half to the control group (CG) and the other randomly to: Group 1: 25 samples treated with 15% hydrogen peroxide with nitrogen doped titanium dioxide. Group 2: 25 samples treated with 35% hydrogen peroxide. Square samples (2x2 mm.) were obtained and observed by SEM (magnification of 5.000x and 10.000x). Results: All treated groups showed longitudinal depressions on the surface and increased surface roughness. Conclusions: Tooth bleaching with hydrogen peroxide produces subclinical alterations over bovine enamel surface. 15% hydrogen peroxide bleaching agent produced less micromorphology alteration over bovine enamel surface than the 35% hydrogen peroxide agent.

Transtornos reprodutivos causados por agentes infecciosos em animais de canis comerciais da microrregião de Ribeirão Preto, estado de São Paulo

Pós-graduação em Medicina Veterinária - FCAV

Atributos produtivos e qualitativos de grãos e fisiológicos e sanitários das sementes de cultivares de feijão

Pós-graduação em Agronomia (Produção Vegetal) - FCAV

Lei de responsabilidade educacional: direito fundamental à educação, regime jurídico administrativo e responsabilização dos agentes públicos

Pós-graduação em Educação - FCT

Parâmetros ruminais e produtivos de cabras alimentadas com raspa de mandioca em substituição ao milho

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Efeitos da adição de agentes tróficos na dieta de leitões desmamados sobre a expressão da enzima ornitina descarboxilase, os conteúdos de proteína e DNA e o desempenho

Two experiments were carried out to evaluate the effect of adding glutamine, fish oil or yeast cellular wall to the diet of weaned piglets on the expression of the enzyme ornithine decarboxylase (ODC), the protein content and DNA in small intestine samples and on performance. In the first experiment, 24 weaned piglets were used to measure the performance at the phases prestarter, starter 1 and starter 2. Four diets were tested (T1 -basal diet (BD); T2 -BD + 1% of glutamine; T3 -BD + 0,2% of yeast cellular wall; T4 -BD + 5% of fish oil). At the second experiment 45 weaned piglets were used and distributed in a randomized block design, in factorial outline with four diets and three slaughter ages (on the day of weaning, on the seventh and fourteenth days postweaning). The tested diets did not alter the piglets' performance in none of the phases. There was reduction of the expression of the ODC enzyme, of the protein concentration and of the relationship protein/DNA to the seven days postweaning, with increase of the values on the 14th day, evidencing a state of hypotrophy of the mucous membrane, suggesting that the process of protein synthesis in the small intestine was diminished in the first week after weaning, but it presented recovery signs in the second week.

Síntese de aminochalconas e análogos arílicos como agentes antivirais, antifúngicos e inibidores de mieloperoxidase

Pós-graduação em Química - IBILCE

Influência de tratamentos de superfície e agentes cimentantes na sobrevivência de coroas de Y-TZP recobertas por porcelana

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Diagnóstico sorológico e molecular de agentes transmitidos por artrópodes em aves carnívoras

Pós-graduação em Medicina Veterinária - FCAV

As dimensões geográficas dos Arranjos Produtivos Locais

This article aims to further discuss the Local Productive Arrangements (APLs), considering some geographical visions thinking about spatial configuration and the economic and social processes that characterize them, configuring a wide range of territorialities and productive territories that mark the landscape current Brazilian. In this sense, APLs are present today in both the figure of those who study analytical concept for regional development, and as a public policy supporting networks and supply chains in their territorial bases, especially small businesses. Thus, this arrangements can be read, geographically, as territorial productive specializations that are configured in spatial circuits of production, integrated with other regions, localities and supply chains through the morphology of networks and districts and grounded in networks of urban networks of material and immaterial flows which are bringing urban centers of different sizes. Considering the multidimensionality of the subject, the clusters have certain weaknesses in terms of their assumptions and perspectives, especially the limitations of the tool if designed just for resources and policies applied at the local level. Suggest the approach of a "geography of APLs" is to seek treat it from a territorial and socio reading.

A comercialização de uvas finas na região de Jales – SP

A produção de uvas finas para mesa destaca-se entre as principais atividades econômicas da região noroeste do Estado de São Paulo, Brasil. Entretanto, os produtores comumente apontam os problemas relativos à comercialização da fruta como um dos mais importantes obstáculos interpostos ao desenvolvimento da fruticultura regional. Este trabalho analisa as transações entre produtores e agentes de comercialização da fruta, discutindo as estruturas de governança presentes e as razões que explicam a exposição dos produtores a comportamentos oportunísticos associados aos distribuidores. Conclui-se que produtores que desenvolvem sistemas produtivos mais especializados, ofertadores de frutas de melhor qualidade, são atendidos por agentes de intermediação também especializados e, portanto, estão menos expostos a comportamentos oportunísticos. Nestes casos, a relação entre os agentes torna-se mais efetiva e sistemática, e a estrutura de governança transita de coordenação via mercado para formas híbridas.

Indicadores bibliométricos em ciência da informação: análise dos pesquisadores mais produtivos no tema estudos métricos na base Scopus

This research aims at analyzing the indicators of impact and relevance - total of published articles, average of citations, total number of citations and index h of the most productive researchers in the Metric Studies field, within periods of the Scopus base by means of a correlation study, determining the best equation of regression of index h due to the total of citations, as well as to all other indicators under analysis. As research procedure, we used the search terms bibliometr* OR scientometr* OR infometr* OR webometr* OR informetr* OR webmemetr* OR paentometr*, obtaining 36 researchers as the most productive ones. For each indicator, the following descriptive statistics were calculated: maximum, minimum, average, standard deviation and coefficient of variation. The coefficient of correlation of Pearson was calculated and adjusted to the equation of regression of index h due to the total of citations. The equation of multiple regression was identified, from index h due to the other indicators. Concluding, we highlight the need for a matching of such indicators to broadly describe a researcher's multifaceted profile, seeing the complementarity of information provided by the indicators of productivity and impact, from distinctive nature.

Atributos do solo e componentes produtivos da soja: Uma abordagem linear, multivariada e geoestatística

Pós-graduação em Agronomia - FEIS

Estudo comparativo in vitro do efeito da ciclagem térmica sobre a resistência à tração de copings metálicos cimentados sobre dentes naturais, utilizando se de dois agentes cimentantes

Pós-graduação em Odontologia Restauradora - ICT