214 resultados para Efeitos tardios da exposição pré-natal


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Odontologia Restauradora - ICT

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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No reservatório de Salto Grande (22º53’53’’S / 49º59’33’’W), Rio Paranapanema (SP/PR), é realizado um tipo de manejo (redução do nível de água) para redução da biomassa da macrófita submersa Egeria densa desde 2004. Estas plantas causam perdas econômicas para o programa de geração elétrica e infortúnio para a população local. O reservatório de Salto Grande possui lagoas marginais que apresentam elevada densidade dessas macrófitas e são tidas como ambientes de alta importância para o desenvolvimento, alimentação e reprodução de muitas assembléias, principalmente as de microcrustáceos zooplanctônicos. O objetivo deste trabalho foi analisar as mudanças na estrutura (composição, riqueza, abundância e diversidade) das assembléias de microcrustáceos zooplanctônicos (Cladocera e Copepoda) e suas relações com as alterações nas condições limnológicas decorrentes da variação de nível em duas lagoas marginais (Pedra Branca e Guaritá) em função do deplecionamento. Foram realizadas amostragens mensais de abril/2005 a julho/2006, além de coletas nictemerais durante o processo de deplecionamento (agosto/05) e um mês após o mesmo. Para a análise do zooplâncton foram amostrados 150 litros de água superficial em cada lagoa (região limnética). Simultaneamente, foram medidas as variáveis físicas e químicas da água: temperatura, pH, oxigênio dissolvido, condutividade elétrica, transparência, turbidez, material em suspensão (total, frações orgânica e inorgânica) e concentração de clorofila a. As variáveis limnológicas demonstraram um padrão de variação sazonal, além da influência do deplecionamento, principalmente sobre a temperatura e oxigênio dissolvido. O valor de riqueza encontrado para Cladocera foi elevado, totalizando 49 táxons. Os Copepoda foram analisados apenas até o nível de Ordem... (Resumo completo, clicar acesso eletrônico abaixo)

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The object of this study was assess through pre-clinical tests, the possible diuretic activity and the effects on the mean arterial pressure of the aqueous and ethanolic extracts of branches of “bugre”, Hedyosmum brasiliense Miq., species used in the treatment of renal and urinary disorders The tests were made in males anesthetized Wistar rats and randomly distributed into 4 experimental groups: Group I – Water control, group II – treated with aqueous extract (EA) of “bugre”, Group III – water control + “tween 80”, group IV – treated with ethanol extract (EE) and “bugre”. All groups were subjected to experimental protocol, composed of three periods: Balance (40 minutes), Basal (30 minutes) and Experimental (90 minutes), occurring the urine collection every 30 minutes, from the basal period and measuring blood pressure every 10 minutes. The results presented validate the ethnobotany indication of the use of H. brasiliense tea in the treatment of renal problems, because increased significantly the urinary flow in anesthetized Wistar rats (diuretic effect), without changing significantly (p>0,05) the arterial pressure

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Este trabalho teve como objetivo principal avaliar a influência de um período de chuvas intensas sobre as assembléias zooplanctônicas e variáveis limnológicas dos reservatórios de Chavantes e Salto Grande. Em função das precipitações elevadas, o tempo de residência da água durante o período de verão 2009/2010 (período imediatamente anterior às coletas) foi o mais baixo da década (1999-2010), tanto para Chavantes como para Salto Grande. As variáveis analisadas foram: transparência, temperatura, oxigênio dissolvido, pH, condutividade elétrica, turbidez, material em suspensão, clorofila a e nutrientes (nitrogênio total, fósforo total e silicato dissolvido). A turbidez foi a variável que mais se alterou, apresentando um aumento notável com o incremento das chuvas. A transparência e o material em suspensão também apresentaram grande alteração, sendo que a primeira variável diminuiu com a maior quantidade de chuvas e a segunda aumentou. Os valores de fósforo total e silicato dissolvido diminuíram com o aumento das chuvas, sendo que para o silicato a variação foi mais expressiva e para o fósforo o decréscimo foi mais acentuado em Chavantes do que em Salto Grande. Para as outras variáveis limnológicas, bem como para o zooplâncton, os dois reservatórios apresentaram comportamentos diferentes quanto às alterações pluviométricas. A temperatura variou mais em Chavantes. Condutividade elétrica e pH apresentaram relação com a temperatura e o oxigênio dissolvido não teve muita alteração com as mudanças pluviométricas. Os atributos analisados para o zooplâncton foram riqueza, composição, abundância (total, por táxon e das fases de desenvolvimento) e diversidade. Comparando os dois reservatórios estudados, foi observado que em Chavantes o aumento pluviométrico teve efeito muito ...(Resumo completo, clicar acesso eletrônico abaixo)

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This paper demonstrates that in every society there are limits and these are imposed on its members. However, the awareness and the determination of theses limits are necessarily how they are transmitted by the educator to the learners. Its purpose is to show that autonomous, critical and cooperative individuals are result of the form they were educated and instructed in the classroom. Schools and educators should be concerned with the education of individuals able to reflect, discuss and solve the social and moral conflicts through dialogue, exposition of ideas, suggesting alternatives and the preparation and reworking of the principles and norms that govern society. The goal of this study is identify and highlight the importance of educator language in conflict resolution, its consequences and effects on the process of building the moral autonomy of children in preschool, as well as discussing, in theory the two types of language, evaluative and descriptive. In the same way, show the importance of descriptive language on the construction process from moral autonomy of learner. Several existing research about the chosen subject led to face this challenge, deepening the study to show that and educational system focused on cooperative environment, where teacher actions encourage social interaction, giving the student opportunity to talk, argue and present his thoughts, causes a significant development toward the construction of moral autonomy on the learner

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It is known that exposure to substances in the environment can contribute to various reproductive disorders, especially if such exposure occurs during critical periods of development such as the intra-uterine and postnatal. The female reproductive system may be the target of androgens, both as a result of exposure to environmental chemicals, or by pathological conditions (polycystic ovary syndrome or congenital adrenal hyperplasia).Usually, little attention is given off in relation to the study of androgenic effects in the female reproductive axis. This study aims to evaluate the effects of exposure to androgens on the development, structure and reproductive function in rats whose mothers were exposed to testosterone propionate from gestational day 12 (DG12) after weaning - postnatal day 21 (DPN21) . For this purpose, pregnancy rats were divided into four groups: a control group that received corn oil (vehicle) and three groups receiving testosterone propionate in doses of 0.05 mg / kg / day, 0.1 mg / kg / day and 0.2 mg / kg / day, all under the same experimental conditions. The possible effects of exposure were assessed using reproductive parameters, such as a measure of anogenital distance, count areolas / nipples, age at vaginal opening and first estrus (puberty indicative installation), weight and histological evaluation of the reproductive organs ( uterus and ovaries), weight of the kidneys, liver and pituitary hormone levels, regularity of the estrous cycle, sexual behavior and fertility. Such analysis is important in understanding the effects of androgen exposure on the female genital system, especially on the reproductive potential, and processes that may involve morphofunctional changes. In these experimental conditions, it is concluded that treatment with PT caused reduction in body weight and initial masculinization in females without cubs, however, commit further sexual development

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Plumbism is considered the oldest occupational disease. Among the pathophysiological effects associated with lead (Pb) are cardiovascular disorders. Many diseases that develop later in life are determined during the early stages of life, under the influence of exposure and preferred diet of the mother. Still, one should consider that many environmental contaminants at levels not harmful can determine pathophysiological processes if physical or chemical stressors and/or pathological conditions are present. In this context, the intrauterine malnutrition may represent an additional risk factor in exposure to Pb during pregnancy and lactation. For these reasons, the objective of this study was to evaluate the cardiovascular risk of weaned rats that have suffered perinatal exposure to Pb and intrauterine malnutrition, alone or in combination. After mating, female rats were divided into control (ctrl, ad libitum), food restriction (RA, the same diet 50% of consumption in the control group during pregnancy), exposed to Pb (500 ppm Pb in drinking water during pregnancy and lactation) and association (As, received the last two procedures in combination). Cumulative concentration-effect curves (CECs) to CaCl2 and noradrenaline (NA) were obtained in rings with and without endothelium of the same thoracic aorta from male weaned rats (23-25 days old). Maternal weight, litter weight, weight and number of pups at birth, anogenital distance, arterial blood pressure (ABP) and weight of tissues (kidney, liver, aorta, left ventricle) were evaluated. Changes in vascular reactivity were assessed by the maximum response (MR) and 50% effective concentration (EC50). Data were presented as mean ± SEM. Statistical analysis was performed by multifactorial analysis of variance and Tukey's post test. Body weight of dams did not differ between the experimental groups, except on the...(Complete abstract click electronic access below)

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Pós-graduação em Agronomia (Proteção de Plantas) - FCA