Is there post-meiotic transcriptional activity during hemipteran spermiogenesis?

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

ROCK1 as a novel prognostic marker in vulvar cancer

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Avaliação do equilíbrio, mobilidade e flexibilidade em idosas ativas e sedentárias

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Dutovias: aspectos gerais e a questão ambiental na definição de trajetos terrestres

Taking into account the consistent and important expansion of the Brazilian oil and gas pipelines network in the last years, this work discusses how these lines are planned regarding the continental environmental context. Its central objective is to show how studies to select alternative lines are made before a gas or oil pipeline is installed. These studies help to choose routes in which the environment is less affected by the pipeline, and use specific methods, technologies, and tools. Bibliographical studies combined with interviews and discussions with experts of the oil and gas sector were used to support this monograph.

Utilização do método AHP para análise de alterações de projetos, em instalações hospitalares

Customer focus , high competitiveness and striving for excellence in quality of service are some of the main features of the current market . Planned and make decisions with greater certainty is no longer an option a few years . The current managers are seeking ways to eliminate waste and increase financial and productive profitability of your company in order to achieve higher performance at a lower cost . The AHP is one of the main concepts of this goal by providing an analysis on multiple criteria , enhancing decision-making and enhancing the gains , with a technique that is designed to take into account all the key criteria for choosing an alternative , according to the perspective of the designer as both suppliers and customers . Emerging as a new way to minimize errors , and make an informed and consistent decision. The use of this method in construction projects is a recent phenomenon , which has much to be explored , an intense analysis of the processes is required to enable it to consider the concepts and present a consistent and grounded proposal

Associação entre expressão de receptores TLR2 e TLR4 e produção de TNF-alpha e IL-10 por monócitos de gestantes portadoras de pré-eclâmpsia

Preeclampsia (PE) is a pregnancy specific syndrome characterized by a systemic inflammatory response, with higher intensity than that observed in normal pregnancy. Cells of the immune system, such as monocytes and granulocytes are endogenously activated and secrete high levels of free radicals and inflammatory cytokines. The objective of this study was to assess the activation state of monocytes from pregnant women with preeclampsia by endogenous expression of TLR2 e TLR4 receptors and to correlate the expression of TLR2 and TLR4 on monocytes surface of pregnant women with PE with the production of tumor necrosis factor-alpha (TNF- and interleukin-10 (IL-10) by these cells stimulated or not with peptidoglycan (PG) and lipopolysaccharide (LPS), as agonists agents of TLR2 and TLR4, respectively. We evaluated 15 pregnant women with PE, 15 normotensive pregnant women (NT) and 15 non-pregnant (NP). Peripheral blood monocytes were incubates in the presence or absence of LPS or PG. The supernatant obtained after 18h of culture was aspirated and used for TNF- and IL-10 determination by enzyme immunoassay (ELISA). The endogenous expression of TLR2 and TLR4 receptors was evaluated by flow cytometry. Our results showed significant highly concentrations of TNF- and TLR4 expression in monocytes of preeclamptic women when compared with NT and NP. Normal pregnant women presented higher levels of IL-10 in comparison with PE and NP groups. TLR2 expression was similar in the three groups studied. Therefore, our study highlights the important role of TLR4 in PE and the consequent high production of TNF- by monocytes of these patients, as well as the potential mechanism involving low levels of IL-10 in the pathophysiology of the disease. These observations demonstrate the strong link between the pathology of PE and the immune system of these patients

Terapia do diabetes mellitus em cães

Diabetes Mellitus is caracterized by a disturbance on endocrine pâncreas with reduction in serum levels of insulin. The deficiency or absence of insulin promotes alterations in the metabolism of carbohydrates, lipidis and proteins. The most common clinical signs of disease are polyuria, polydipsia, polyphagia and loses of weight. The diagnosis is made based on clinical symptoms, with laboratory confirmation through persistent hyperglycemia on fasting and glycosuria. Treatment includes insulin therapy, diet, exercise and oral hypoglycemic agents in an attempt to reverse the catabolic effects associated with deficiency or antagonism of insulin and restore normal homeostasis of the metabolism of proteins, lipids and carbohydrates

O ato alimentar em três espécies de Artibeus de grande porte (Chiroptera: Phyllostomidae) do Sudeste brasileiro

The alimentary act of three species of frugivorous bats of the genus Artibeus: A. lituratus, A. fimbriatus and A. planirostris, in a total of nine individuals, was studied by observations in field and captivity, during the months of May to September of 2008. With the objective to caracterize the form of consumption of two tipes of fruits (soft and consistent) and it relates with the dentary structure of this bats, the alimentary act was film and analysed later. It had little variation between the species. The fruits had been consumed in similar way, being that statistics analisis had demonstrated that consistent fruits had received more lateral bytes than the soft fruits. The dentary analisis shown that the posterior teeth (pre-molar and molar) present important characteristcs to triturate pieces of more consistent fruits and the incisors serve to scrape the pulp of the soft fruits. This study it served to describe the form of feeding of frugivorous bats, that little is explained in the studies of alimentary behavior

Peripheral osteoma in the ramus of mandible: report of case

The osteomas are benign rare neoplasms, generally asymptomatic which are characterized by the proliferation of a compact or spongy bone. When they are situated in the maxillofacial area, they affect mainly the mandible, the frontal bone and the paranasal sinus. We have described the case of a female caucasian patient who presented an increased volume in the posterior region of the oral vestibule on the left side. During the clinical examination an oral lesion was observed in the region of the left ramus of mandible. This lesion was motionless, consistent, and painless when palpated. In the image obtained from the computed tomography cone–beam (CBCT), we could observe an hyperdense, cylindrical region, with well defined borders, located in the medial surface of the left ramus of mandible, right below the mandibular notch. Based on clinical data and in the obtained images, we could confirm the presence of the peripheral osteoma in the left side of the ramus of mandible region.

Otimização da operação de sistemas de distribuição radiais usando um algoritmo genético especializado

Pós-graduação em Engenharia Elétrica - FEIS

Nanodisplacement measurements of piezoelectric flextensional actuators using a new interferometry homodyne method

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Nano-displacement measurements of a new piezoelectric flextensional actuator by using a high dynamic range interferometry homodyne method

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Envelhecimento acelerado em diásporos de Oenocarpus bacaba (Arecaceae)

O objetivo do presente trabalho foi adequar o teste de envelhecimento acelerado para avaliar a qualidade fisiológica de diásporos de Oenocarpus bacaba Mart. (bacaba). Inicialmente, os diásporos foram expostos às temperaturas de 41; 43 e 45 ºC, durante 3; 6; 12; 24; 36; 48 e 72 h, com cerca de 100% de umidade relativa do ar. Foram considerados dois critérios de germinação: emissão da primeira bainha igual ou superior a 1cm e plântula normal. o teste de germinação foi realizado com 6 repetições de 20 diásporos, em temperatura de 30 ºC e fotoperíodo de 12 h. Pelos resultados preliminares, observou-se que os lotes de diásporos de bacaba podem ser separados em níveis de vigor por meio do envelhecimento acelerado, em 43ºC e com cerca de 100% de umidade relativa do ar, por 48 h. os quatro lotes de diásporos foram então submetidos, num segundo experimento, a 43 ºC por 24; 48 e 72 h, sendo adotada como critério de germinação a emissão de primeira bainha. em 45 ºC, a porcentagem de germinação foi drasticamente reduzida após 12 h. Não houve diferenças significativas entre os critérios de germinação utilizados. Os lotes de diásporos foram separados em diferentes níveis de vigor após 48 e 72 h de exposição a 43 ºC. de acordo com os resultados obtidos, sugere-se o uso de primeira bainha como critério de germinação e período de envelhecimento de 48 h a 43 ºC, para a avaliação da qualidade fisiológica de diásporos de bacaba.

Antiproliferative activity of cardenolide glycosides from Asclepias subulata

Asclepias subulata Decne. is a shrub occurring in Sonora-Arizona desert (Mexico-USA). The ethnic groups, Seris and Pimas, use this plant for the treatment of sore eyes, gastrointestinal disorders and cancer. To isolate the compounds responsible for antiproliferative activity of the methanol extract of A. subulata. A bioguided fractionation of methanol extract of A. subulata was performed using MTT assay to measure the antiproliferative activity of different compounds on three human cancer cell lines (A549, LS 180 and PC-3), one murine cancer cell line (RAW 264.7) and one human normal cell line (ARPE-19). The methanol extract was partitioned with hexane, ethyl acetate and ethanol. The active fractions, ethanol and residual, were fractioned by silica-column chromatography and active sub-fractions were separated using HPLC. The chemical structures of isolated compounds were elucidated with different chemical and spectroscopic methods. A new cardenolide glycoside, 12, 16-dihydroxycalotropin, and three known, calotropin, corotoxigenin 3-O-glucopyranoside and desglucouzarin, were isolated of active sub-fractions. All isolated compounds showed a strong antiproliferative activity in human cancer cells. Calotropin was the more active with IC50 values of 0.0013, 0.06 and 0.41 µM on A549, LS 180 and PC-3 cell lines, respectively; while 12, 16-dihydroxycalotropin reached values of 2.48, 5.62 and 11.70 µM, on the same cells; corotoxigenin 3-O-glucopyranoside had IC50 of 2.64, 3.15 and 6.62 µM and desglucouzarin showed values of 0.90, 6.57 and 6.62, µM. Doxorubicin, positive control, showed IC50 values of 1.78, 6.99 and 3.18 µM, respectively. The isolated compounds had a weak effect on murine cancer cells and human normal cells, exhibiting selectivity to human cancer cells. In this study, we found that 12, 16-dihydroxicalotropin, calotropin, corotoxigenin 3-O-glucopyranoside and desglucouzarin are responsible of antiproliferative properties of A. subulata, and that these compounds are highly selective to human cancer cells. Further studies are needed in order to establish the action mechanisms of the isolated compounds.

Efeitos da imersão em água fria na recuperação pós-exercício: análise conjunta de parâmetros clínicos, funcionais, metabólico e autonômico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)