Estudos para obtenção de palmitato de taurina

A taurina (ácido 2-etanoaminossulfônico) apresenta diversas funções fisiológicas, como atuação no neurodesenvolvimento, ação no coração contra arritimias, ação nos músculos esqueléticos contra atrofia, faz parte da bile na forma de um composto conjugado, constutuindo um dos sais biliares, e anti-inflamatória, inibindo mediadores pró-inflamatórios. Neste projeto a ênfase foi voltada para a ação anti-oxidante da taurina, que forma um complexo com espécies como o ácido hipocloroso (HOCl) e ânions clorito (OCl-) que potencialmente possuem ações danosas à célula. Esse complexo, a taurina cloramina (Tau-Cl), possui também ações contra mediadores inflamatórios, como o fator de necrose tumoral alfa (TNF-α) e o óxido nítrico (NO). Por ser uma molécula com alta polaridade e hidrossolubilidade, a taurina não consegue penetrar na pele pelo extrato córneo intacto, a camada mais externa da pele, que constitui sua barreira contra perda ou absorção de água e eletrólitos. Foi feita então a síntese de um pró-fármaco derivado da taurina, formado por seu acoplamento com uma cadeia carbônica longa, aumentando significativamente a lipossolubilidade em relação a taurina pura, e podendo assim, essa molécula, transpor o extrato córneo intacto e exercer sua ação anti-oxidante, podendo ser, portanto, caracterizado como um pró-ativo. Este pró-fármaco, o ácido 2-palmitamidoetanossulfônico, foi sintetizado por meio de uma reação entre um cloreto de acila (cloreto de palmitoíla) e taurina, utilizando trietilamina como base, por meio de um método conhecido por Schotten-Baumann. O produto formado foi analisado por cromatografia em camada delgada (CCD), faixa de fusão, espectroscopia de absorção no infravermelho (IV) e espectometria de massa (EM), sendo que todas as análises confirmaram que a síntese foi bem sucedida

Controle visual da freada em ciclistas: efeitos da incerteza em situação de curva

The purpose of the present study was to analyze the visual control of braking a bicycle when the cyclist is surprised by an obstacle in his way. According to Lee (1976), visually controlled braking based on time to collision information utilizes the optic variables tau and its first derivative in time, tau-dot, to initiating the braking action and regulating its intensity. Seven young adults performed a bicycle braking task in curvilinear trajectory under distinct velocity (high, medium, and low) and uncertainty (certainty and uncertainty) conditions. Results showed that, independently of velocity and uncertainty levels, participants utilized tau and tau-dot to initiating and regulating the braking action, avoiding collision with the obstacle. Cognitive, attentional, and other psychological factors resulting from both increased velocity and uncertainty were not capable of altering the use of time to collision information, corroborating the tested hypothesis

Measurement of the pp → ZZ production cross section and constraints on anomalous triple gauge couplings in four-lepton final states at √s = 8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for displaced supersymmetry in events with an electron and a muon with large impact parameters

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for a standard model-like Higgs boson in the mu(+)mu(-) and e(+)e(-) decay channels at the LHC

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Genetic diversity and molecular phylogeny of Anaplasma marginale studied longitudinally under natural transmission conditions in Rio de Janeiro, Brazil

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Prediction of soil shear strength in agricultural and natural environments of the Brazilian Cerrado

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Reliability of peak O-2 uptake and O-2 uptake kinetics in step exercise tests in healthy subjects

To date little is known about the reliability of peak oxygen consumption (VO2pEAK) in incremental metronome paced step tests (1ST) and the reliability of on-kinetics VO2 has never been studied. We aimed to study the reliability of both tests. Eleven healthy subjects performed two ISTs until exhaustion. On two different days two duplicate 4 min constant metronome paced step tests (CST) were performed. VO2PEAK, mean response time (MRT) and phase II time constant (tau) were tested for reproducibility using the paired t-tests, in addition to the limits of agreement (LOA) and within subject coefficient of variation (COV). With a 95% LOA of 0.38 to 0.26 L min(-1), -8.7 to 9.1 s and -9.9 to 10.5 s they exhibit a COV of 3%, 4.5% and 6.9% for VO2PEAK, MRT and tau respectively. ST are sufficiently reliable for maximal and submaximal aerobic power assessments in healthy subjects and new studies of oxygen uptake kinetics in selected patient groups are warranted. (C) 2014 Elsevier B.V. All rights reserved.

Precise determination of the mass of the Higgs boson and tests of compatibility of its couplings with the standard model predictions using proton collisions at 7 and 8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Rietveld refinement and optical properties of SrWO4:Eu3+ powders prepared by the non-hydrolytic sol-gel method

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Index of thermal stress for cows (ITSC) under high solar radiation in tropical environments

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Search for anomalous production of events with three or more leptons in pp collisions at root s=8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Technicolor contribution to lepton plus photon+E-T events at the Fermilab Tevatron

Events with one lepton, one photon, and missing energy are the subject of recent searches at the Fermilab Tevatron. We compute possible contributions to these types of events from the process pp ->gamma l nu(l)nu(tau)nu(tau), where l=e, mu in the context of a low scale technicolor model. We find that with somewhat tighter cuts than the ones used in the CDF search, it could be possible to either confirm or exclude this model in a small region of its parameter space.

Probing minimal supergravity at the CERN LHC for large tan beta

For large values of the minimal supergravity model parameter tan beta, the tau lepton and the bottom quark Yukawa couplings become large, leading to reduced masses of tau sleptons and b squarks relative to their first and second generation counterparts, and to enhanced decays of charginos and neutralinos to tau leptons and b quarks. We evaluate the reach of the CERN Large Hadron Collider (LHC) pp collider for supersymmetry in the MSUGRA model parameter space. We find that values of m((g) over tilde) similar to 1500-2000 GeV can be probed with just 10 fb(-1) of integrated luminosity for tan beta values as high as 45, so that MSUGRA cannot escape the scrutiny of LHC experiments by virtue of having a large value of tan beta. We also perform a case study of an MSUGRA model at tan beta = 45 where (Z) over tilde(2)-->tau<(tau)over tilde>(1) and (W) over tilde(1)-->tau(1)nu(tau) with similar to 100% branching fraction. In this case, at least within our simplistic study, we show that a di-tau mass edge, which determines the value of m((Z) over tilde 2) - m((Z) over tilde 1), can still be reconstructed. This information can be used as a starting point for reconstructing SUSY cascade decays on an event-by-event basis, and can provide a strong constraint in determining the underlying model parameters. Finally, we show that for large tan beta, there can be an observable excess of tau leptons, and argue that tau signals might serve to provide new information about the underlying model framework. [S0556-2821(99)04205-8].

Expression of estrus modifies the gene expression profile in reproductive tissues on Day 19 of gestation in beef cows

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)