Síntese de pró-fármaco recíproco derivado do ácido micofenólico

O transplante de órgãos é um processo em que se transferem tecidos e/ou órgãos sólidos de um doador vivo ou cadavérico para um hospedeiro. A resposta imune aos aloantígenos, antígenos de um membro da mesma espécie, do doador, caracteriza o processo de rejeição de órgãos. As reações de hipersensibilidade são causadas por respostas imunes controladas inadequadamente, como na formação de complexos antígeno-anticorpo circulantes no Lúpus Eritematoso Sistêmico, ou direcionadas ao tecido do paciente, por resposta de anticorpos, como na Febre Reumática Aguda, e por resposta linfocitária, como na Esclerose Múltipla. A terapia farmacológica para transplantes de órgãos e para reações de hipersensibilidade se baseia na utilização de fármacos imunossupressores, como a prednisona, ciclosporina, anticorpos monoclonais, ácido micofenólico e azatioprina. A talidomida, fármaco com propriedades inibidoras da produção de Fator de Necrose Tumoral Alfa em monócitos, atua como imunossupressor e anti-inflamatório, com atividade de interesse para o tratamento destas condições. Nesse contexto, foi sintetizada, purificada e caracterizada a estrutura química de um novo pró-fármaco planejado para atuar com mecanismo duplo de ação a saber: inibição da inosina 5’-monofosfato desidrogenase e da produção do fator de necrose tumoral alfa.

Isoeritrólise neonatal eqüina

Equine neonatal isoerythrolysis is a neonatal foals’ illness. Results from the incompatibility of blood type between the foal and the mare and mediated by maternal antibody absorbed by the colostrum against foal’s red blood cells. Characterized by a type ll hypersensitivity reaction, where the exhibition of the organism to a strange antigen, that it takes the sensitization of the lymphocytes B that after the removal of the antigens by the reticule-endothelial system the production of immunoglobulin is decreased, with the formation of cellular immunological will cause the occurrence of the illness in foal of sensitized mares. The most important clinical signs are severe anemia and jaundice, and this illness should be differentiated of other as: hemolysis induced by bacterial toxins, diseases of the hepatobiliary system, disseminated intravascular coagulation and incompatibility in blood transfusions. Like the sensitization happens during the previous incompatible foal’s birth, most cases occur in foals of multiparous mares. However during the first pregnancy the mare can generate a foal with neonatal 7 isoerythrolysis if she have developed placental anomaly in the beginning of the pregnancy which blood cells in her circulation

Efeitos da adição de mananoproteínas derivadas da parede celular de leveduras sobre parâmetros imunológicos de cães adultos e idosos

Pós-graduação em Medicina Veterinária - FCAV

Análise da expressão gênica em resposta ao tratamento com Euphorbia tirucalli (Aveloz) em carcinoma epidermóide de laringe

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O desenvolvimento sustentável e o controle social da natureza e do trabalho: um estudo a partir da Fábrica de Preservativos Masculinos de Xapuri (AC)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Farmacocinética da gentamicina asministrada pela via intravensa regional em equinos com a utilização de modelos de torniques

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Dispositivo microfluídico de borracha natural (LAB-ON-A-CHIP)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de um novo sistema dinâmico para avaliação da liberação de fármacos

Pós-graduação em Biociências - FCLAS

Micro-extração em fase sólida (SPME) in situ e comparação de compostos voláteis em variedades de manga (Mangifera indica L.) resistentes e suscetíveis à mosca-das-frutas Anastrepha obliqua (Macquart) (Diptera: Tephritidae)

Pós-graduação em Química - IQ

Importância do tratamento estético periodontal na reabilitação protética

Gingival recession is a common deformity that affects a large number of people. This condition is frequently associated with esthetic complains and may lead to dental hypersensitivity. Thus, various surgical procedures have been proposed to provide root coverage. Since the 1950s, free and pedicle gingival grafts have been greatly used for treating gingival recession. However, after the 1985 Miller gingival recession classification, and with the development of other appropriated techniques that use subepithelial connective tissue grafts, gingival recession treatments have resulted in more predictable outcomes, especially with respect to Class I and II sites, i.e., in the absence of interproximal bone loss. This article reported the importance of aesthetical periodontal treatment in the prosthetic rehabilitation of a patient with a class I gingival recession with 3 mm of vertical extension in the superior canine. The treatment plan consisted of root coverage using subepithelial connective tissue graft (SCTG) associated with construction of new prosthesis.

Tratamento estético periodontal: revisão de literatura sobre alguns tipos de cirurgias

Currently, periodontal aesthetics has been prized for harmony of the smile. The clinical crown lengthening, gingival excess or altered passive eruption, is effectively corrected by periodontal surgery. The purpose of this paper is to show, through a literature review, some types of surgery on clinical crown lengthening and root coverage. Clinical crown lengthening is done to Change the size of the anterior teeth and to optimize the cosmetic result of treatment with new coronal restoration and other cosmetic dental care. In general, the treatment plan and the choice of operative technique begin with careful clinical examination. Recessions tissue can be defined as a displacement of the gingival margin toward the junction mucogingival exposing the root surface. These, when present, impacting on patient comfort by providing the occurrence of cervical dentin hypersensitivity, and the esthetic, the amendment of the gum line. Successful treatment of recessions is based on knowledge of its etiology and assessment of predictability of surgical techniques that aim to root coverage. Through literature review, we can conclude that the types of surgery most often used are: 1) to increase the clinical crown, gingivectomy, flap surgery and gingivoplasty osteotomy, and 2) for root coverage, the use will depend on the amount of gum keratinized and especially the classification of Miller.

Importância do tratamento estético periodontal na reabilitação protética

Gingival recession is a common deformity that affects a large number of people. This condition is frequently associated with esthetic complains and may lead to dental hypersensitivity. Thus, various surgical procedures have been proposed to provide root coverage. Since the 1950s, free and pedicle gingival grafts have been greatly used for treating gingival recession. However, after the 1985 Miller gingival recession classification, and with the development of other appropriated techniques that use subepithelial connective tissue grafts, gingival recession treatments have resulted in more predictable outcomes, especially with respect to Class I and II sites, i.e., in the absence of interproximal bone loss. This article reported the importance of aesthetical periodontal treatment in the prosthetic rehabilitation of a patient with a class I gingival recession with 3 mm of vertical extension in the superior canine. The treatment plan consisted of root coverage using subepithelial connective tissue graft (SCTG) associated with construction of new prosthesis.

In vitro evaluation of Biosilicate® dissolution on dentin surface: a SEM analysis

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Dipirona versus paracetamol no controle da dor pós-operatória

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Síntese e caracterização de blendas borracha natural/polianilina e borracha natural/polipirrol obtidas por polimerização in situ

Pós-graduação em Ciência dos Materiais - FEIS