Terapêutica com doses profiláticas de sulfato ferroso como medida de intervenção no combate à carência de ferro em crianças atendidas em unidades básicas de saúde

Objetivou-se testar a terapêutica com doses profiláticas de sulfato ferroso no combate à anemia carencial ferropriva, em 620 crianças de 4 a 36 meses de idade, atendidas em duas unidades de saúde do Município de São Paulo, Brasil. As crianças foram submetidas a coleta de sangue para dosagem de hemoglobina. em seguida, foi prescrito dosagem de 12 mg/dia de ferro elementar, por 30 dias. Observou-se que 25% dos menores de 6 meses apresentaram níveis de hemoglobina inferiores a 11,0 g/dl. As maiores ocorrências de anemia foram detectadas entre os 9 e 23 meses de idade (50,0%). Decorrido o prazo, apenas 37,4% das crianças com anemia e 52,4% das não anêmicas retornaram para reavaliação. Das 299 que foram reavaliadas, somente 157 (52,5%) receberam a medicação corretamente. A freqüência de hemoglobinas inferiores a 9,5 g/dl caiu de 17,1% no início, para 8,1% ao final da intervenção. Por outro lado, o percentual de crianças com hemoglobinas superiores a 12,0 g/dl subiu de 13,4%, para 33,4%. As que receberam a suplementação férrica de forma correta registraram queda nos índices de anemia sensivelmente maior que a observada naquelas suplementadas de forma incorreta. Concluiu-se que a terapêutica com doses profiláticas de sulfato ferroso, apesar de se mostrar eficiente na recuperação dos níveis de hemoglobina, apresenta sérios entraves do ponto de vista operacional.

Conhecimentos de professores sobre perda auditiva e suas atitudes frente á inclusão

OBJETIVOS: verificar os conhecimentos dos professores sobre a perda auditiva, suas opiniões sobre a educação de alunos com esse tipo de privação sensorial e também conhecer suas atitudes frente à proposta da inclusão. MÉTODOS: participaram desta pesquisa quatro grupos de professores do ensino fundamental, com e sem experiência com aluno com perda auditiva. Os instrumentos utilizados na coleta de dados foram a Escala Lickert de Atitudes Sociais em Relação à Inclusão (ELASI) e um questionário. Comparações entre os resultados de diferentes grupos, por meio de provas estatísticas apropriadas, foram feitas, sempre que a natureza dos dados o recomendava. RESULTADOS: os professores de 1ª a 4ª séries, com e sem experiência com alunos com perda auditiva, apresentaram respostas semelhantes com referência às atitudes sociais acerca da inclusão, tanto na dimensão ideológica quanto na operacional. Professores de 5ª a 8ª séries, com e sem experiência com alunos com perda auditiva, apresentaram respostas semelhantes nos itens ideológicos, porém divergiram nos itens operacionais. em relação aos conhecimentos, os grupos de professores com experiência não apresentaram conhecimentos diferenciados sobre aspectos relativos à perda auditiva, quando comparados com os grupos de professores sem experiência, e todos os grupos enfatizaram os aspectos comunicativos. CONCLUSÃO: a análise revela que os dados provenientes de diferentes instrumentos se complementam e sugerem que os professores são ideologicamente favoráveis à inclusão, entretanto, não têm conhecimentos suficientes para operacionalizar tal proposta.

Immobilization of lipases and assay in continuous fixed bed reactor

Lipases are versatile enzymes regarding the range of reactions they catalyse and substrates on which they act. They are as well important as catalyst in organic synthesis. Their immobilization on appropriate supports confer them greater stability besides the possibility of operating in continuous reactors. In order to explore these abilities, the reactions involving hydrolysis of p-nitrophenyl acetate (PNPA) and transesterification of PNPA with n-butanol were chosen. Lipases from two different sources were assayed, namely: microbial (Candida rugosa, CRL, Sigma Type VII) and pancreatic (PPL, Sigma, Type 11). Two immobilization methods were also used, namely: 1) adsorption, using as support the following silica derivatives (150-300μm e 450μ): phenyl, epoxy, amino and without derivation, and 2) covalent binding, using glutaraldehyde as binding agent and silica amino as support. This later method led to better results. Hydrolytic activity was 6.1 U/gsupport for CRL and 0.97U/gsupport for PPL, and of transesterification, 2,8U/gsupport for CRL and 1,9U/gsupport for PPL. Stability of the immobilized enzyme as a function of temperature was evaluated for CRL at 40°C and 50°C and for PPL at 32°C and 40°C. The assays were initially carried out batchwise, both for soluble and immobilized enzymes, aiming to the obtention of parameters for the continues reactor. Lipases immobilized by covalent binding were used in the assays of operacional stability in continuos reactors. For PPL in aqueous medium, at 32°C, and CRL in organic medium at 40°C, both operating continuously, no significant loss of activity was detected along the analysis period of 17 days. In the case of CRL in aqueous medium at 40°C there was a loss of activity around 40% after 18 days. For PPL in organic medium at 40°C the loss was 33% after 20 days. Compairing both sources with each other, very different results were obtained. Higher activitiy was found for CRL, both for hydrolysis and for transesterification reactions, with higher stability in organic medium. PPL showed lower activity as well as higher stability in aqueous medium. The immobilization method by covalent binding showed to be the most appropriate. Immobilized lipases are therefore relatively stable both in aqueous and organic medium.

Synthetic control charts with two-stage sampling for monitoring bivariate processes

In this article, we consider the synthetic control chart with two-stage sampling (SyTS chart) to control bivariate processes. During the first stage, one item of the sample is inspected and two correlated quality characteristics (x;y) are measured. If the Hotelling statistic T1 2 for these individual observations of (x;y) is lower than a specified value UCL 1 the sampling is interrupted. Otherwise, the sampling goes on to the second stage, where the remaining items are inspected and the Hotelling statistic T2 2 for the sample means of (x;y) is computed. When the statistic T2 2 is larger than a specified value UCL2, the sample is classified as nonconforming. According to the synthetic control chart procedure, the signal is based on the number of conforming samples between two neighbor nonconforming samples. The proposed chart detects process disturbances faster than the bivariate charts with variable sample size and it is from the practical viewpoint more convenient to administer.

The use of principal components and univariate charts to control multivariate processes

In this article, we evaluate the performance of the T2 chart based on the principal components (PC chart) and the simultaneous univariate control charts based on the original variables (SU X̄ charts) or based on the principal components (SUPC charts). The main reason to consider the PC chart lies on the dimensionality reduction. However, depending on the disturbance and on the way the original variables are related, the chart is very slow in signaling, except when all variables are negatively correlated and the principal component is wisely selected. Comparing the SU X̄, the SUPC and the T 2 charts we conclude that the SU X̄ charts (SUPC charts) have a better overall performance when the variables are positively (negatively) correlated. We also develop the expression to obtain the power of two S 2 charts designed for monitoring the covariance matrix. These joint S2 charts are, in the majority of the cases, more efficient than the generalized variance |S| chart.

A resolução do problema de despacho ótimo de reativos pelo método da função Lagrangiana-barreira relaxada

This work presents the application of the relaxed barrier-Lagrangian function method to the optimal reactive dispatch problem, which is a nonlinear nonconvex and large problem. In this approach the inequality constraints are treated by the association of modified barrier and primal-dual logarithmic barrier method. Those constraints are transformed in equalities through positive auxiliary variables and are perturbed by the barrier parameter. A Lagrangian function is associated to the modified problem. The first-order necessary conditions are applied generating a non-linear system which is solved by Newton's method. The auxiliary variables perturbation result in an expansion of the feasible set of the original problem, allowing the limits of the inequality constraints to be reach. Numeric tests with the systems CESP 53 buses and the south-southeast Brazilian and the comparative test with the primal-dual logarithmic barrier method indicate that presented method is efficient in the resolution of optimal reactive dispatch problem.

Double sampling X̄ control chart for a first order autoregressive process

In this paper we propose the Double Sampling X̄ control chart for monitoring processes in which the observations follow a first order autoregressive model. We consider sampling intervals that are sufficiently long to meet the rational subgroup concept. The Double Sampling X̄ chart is substantially more efficient than the Shewhart chart and the Variable Sample Size chart. To study the properties of these charts we derived closed-form expressions for the average run length (ARL) taking into account the within-subgroup correlation. Numerical results show that this correlation has a significant impact on the chart properties.

Monitoring bivariate processes

The T2 chart and the generalized variance |S| chart are the usual tools for monitoring the mean vector and the covariance matrix of multivariate processes. The main drawback of these charts is the difficulty to obtain and to interpret the values of their monitoring statistics. In this paper, we study control charts for monitoring bivariate processes that only requires the computation of sample means (the ZMAX chart) for monitoring the mean vector, sample variances (the VMAX chart) for monitoring the covariance matrix, or both sample means and sample variances (the MCMAX chart) in the case of the joint control of the mean vector and the covariance matrix.

Reformulação para um problema integrado de dimensionamento e sequenciamento de lotes

In this paper, some new constraints and an extended formulation are presented for a Lot Sizing and Scheduling Model proposed in the literature. In the production process considered a key material is prepared and is transformed into different final items. The sequencing decisions are related to the order in which the materials are processed and the lot sizing decisions are related to the final items production. The mathematical formulation considers sequence-dependent setup costs and times. Results of the computational tests executed using the software Cplex 10.0 showed that the performance of the branch-and-cut method can be improved by the proposed a priori reformulation.

A practical guide for operational validation of discrete simulation models

As the number of simulation experiments increases, the necessity for validation and verification of these models demands special attention on the part of the simulation practitioners. By analyzing the current scientific literature, it is observed that the operational validation description presented in many papers does not agree on the importance designated to this process and about its applied techniques, subjective or objective. With the expectation of orienting professionals, researchers and students in simulation, this article aims to elaborate a practical guide through the compilation of statistical techniques in the operational validation of discrete simulation models. Finally, the guide's applicability was evaluated by using two study objects, which represent two manufacturing cells, one from the automobile industry and the other from a Brazilian tech company. For each application, the guide identified distinct steps, due to the different aspects that characterize the analyzed distributions. © 2011 Brazilian Operations Research Society.