Síntese de microesferas de quitosana para aplicação em liberação controlada de drogas pelo método de atomização e coagulação

Chitosan is a natural biodegradable polymer with great potential for pharmaceutical applications due to its biocompatibility, high charge density , nontoxicity and mucoadhesion. Gel formation can be obtained by the interactions of chitosans with low molecular counterions such as polyphosphates, sulphates and crosslinking with glutaraldehyde. This gelling property of chitosan allows a wide range of applications such as coating of pharmaceuticals and food products, gel entrapment of biochemicals, whole cells, microorganisms and algae. One of its main applications is the synthesis of microspheres for coating of pharmaceuticals , magnetic particles an other substances. In such a way, we can build targeted drug delivery systems. In the present work, we applied the method of spraying and coagulation. The resulting microspheres, then, were characterized by optical microscopy

Avaliação da segurança das prescrições médicas de usuários de insulina: estudo piloto

A prescrição médica de insulina e outros medicamentos pode apresentar comprometimento de sua segurança, diante de problemas envolvendo ilegibilidade e ausência de informações. Como consequência instala-se falhas na comunicação e no entendimento do conteúdo prescrito, o que pode ocasionar um erro de medicação com prejuízo terapêutico. Diante disto, o presente trabalho, parte integrante da pesquisa de doutorado “Desenvolvimento e avaliação de um protocolo de atenção farmacêutica intensiva com metodologia educacional de empoderamento para adultos com Diabetes Mellitus tipo 2 – estudo translacional fase 1”, desenvolvido por Drª . Silvia F. L. Cavalheiro, sob orientação da Profª . Drª . Chung Man Chin, teve como objetivo avaliar a segurança das prescrições médicas contendo insulina através da Triagem Técnica das Prescrições Médicas (TTPM), com o intuito de checar eventuais problemas que pudessem afetar a eficácia terapêutica. Metodologia: foi realizado um estudo transversal retrospectivo de 16 prescrições médicas, de 9 adultos com DM2 usuários de insulina. A TTPM foi realizada através da utilização do instrumento específico, elaborado para este fim, onde foram checados eventuais problemas que poderiam afetar a segurança da prescrição de insulina. Resultados e Discussões: foi observado que todas as receitas médicas apresentavam algum problema que pudesse afetar a segurança da prescrição. Dentre os problemas mais observados a falta de informações sobre o paciente (idade e/ou endereço) e o uso de abreviaturas foi encontrada em todas as prescrições. A omissão de dados sobre o prescritor, ou local onde trabalha, como endereço e/ou telefone foi encontrada em 94% das prescrições. Além do mais, 74% das prescrições foram consideradas ilegíveis ou pouco legíveis. Conclusão: os problemas observados envolvem a prescrição inadequada... (Resumo completo, clicar acesso eletrônico abaixo)

Acompanhamento farmacoterapêutico de usuários portadores de dislipidemia: um projeto piloto

As Doenças Cardiovasculares (DCV) são a principal causa de morte no mundo e no Brasil. A dislipidemia é um dos principais fatores de risco associados a DCV, o descontrole no perfil lipídico impacta na aterosclerose e na diminuição da sobrevida. A dislipidemia pode ser tratada farmacologicamente ou através de medidas para mudanças do estilo de vida. O farmacêutico, como profissional da saúde especializado em medicamentos, está habilitado para solucionar Resultados Negativos associados a Medicação (RNMs), trabalhar na melhoria da adesão e na educação em saúde. Este estudo tem o objetivo de implementar um projeto piloto de acompanhamento farmacêutico em usuários com dislipidemia diagnosticada. Método: Foram selecionados 20 indivíduos com idade entre 40 e 64 anos, atendidos na unidade básica de saúde Parque São Paulo, do município de Araraquara- SP (Brasil) que eram diagnosticados com dislipidemia há pelo menos 3 meses e eram usuários de pelo menos um medicamento para tratamento da dislipidemia. Os pacientes foram divididos em dois grupos: o grupo controle, que não receberá intervenção farmacêutica e o grupo intervenção que receberá acompanhamento farmacêutico através do método Dáder, durante o período de 4 meses de estudo. Foram investigadas as variáveis sócio-demográficas, as relacionadas aos hábitos alimentares, as terapêuticas (uso de medicamentos, adesão terapêutica); Escala de auto-relato de adesão desenvolvida por Morisky. Os parâmetros bioquímicos/fisiológicos foram mensurados através do aparelho portátil Accutrend Plus(Roche) de medida do colesterol e triglicérides. Resultados: O presente estudo demonstrou que as intervenções farmacêuticas relacionadas ...

Satisfação dos Usuários do Ambulatório Geral do Hospital das Clínicas de Botucatu

The searches for a health service it’s a part of a process, searches for a qualified evaluation can arise the perception, in form of irritating factors taking for an alert state. The personal expectation, it makes influence in its perceptions, too. The objective was to evaluate the satisfaction degree of the users of “Seção Técnica de Ambulatório Geral do Hospital das Clínicas de Botucatu”. The work is about a quantitative and transversal study, with calculated sample of 366 users, chosen randomly and invited to participate through a questionnaire. The population was compounded by a majority of women (64,5%), between 50 to 59 years old and average degree of education (38,3%). 25 specialties were cited. The evaluate about comfort, cleaning, reception, waiting time, medical attention and nursing vary between “very good” and “good”. Obtained significant “regular” assessment, the comfort in the waiting rooms (24%), silence (25%) and cleaning bathroom (63%). Others negative evaluation was the reception about the waiting time (26%), waiting time between arrival and the consultation (34%), waiting time between the request and consultation (27%). 30,6% report to know the place for complaints and 79,4% of these pointed to the ombudsman. 62% consider their problems solved, 84,4% would indicate the hospital, 57,4% would consider the hospital better than imagined. 42,62% used the opened area for thanking, critical for staff, suggestion infrastructure improvements, cleaning and waiting time. The biggest complaint was the staff turnover in the treatment. There was disharmony between the objective and subjective questions, but, all of them must be considered to propose improvements. The satisfaction evaluation makes the service more effective, bringing credibility to the health service and the patients adhere better to the treatment

Compreendendo o acolhimento em uma unidade de saúde da família na perspectiva dos usuários

The present study aimed at understanding humanized reception at a Family Health Unit in a city in São Paulo state according to users’ perspectives. It is a qualitative investigation with a Case Study as its methodological framework and the Theory of Complexity (TC) as its theoretical basis. Data were collected from March to July, 2011 by means of non-directive interviews and participant observation, and the Flowchart that analyzes the care provision model in health care services was used. The discourses were analyzed according to Bardin’s thematic approach, from which two themes emerged: humanized reception as an act that precedes medical consultation and humanized reception as a solution to demands stemming from medical action. The study provided visibility to the forms how humanized reception is understood, that is, the moment that precedes medical consultation, being configured as a pre-consultation instance when punctual actions are performed, such as measuring vital signs, and when users are sure that they will be seen by a doctor, in addition to the perception that humanized reception is not part of the process to solve their need, since such result is achieved by means of medication dispensation permeated by the polite treatment given by professionals. These results show how the fragmented, reductionist and linear approach to caregiving is still present in the words, thoughts and culture of health service users as well as in those of health care team members. TC seems to shed light on these issues, and it may result in important improvement in the understanding of interactional relationships between team members and users concerning the work process in the Family Health model as the main strategy in Primary Care

Detecção de marcadores de resistência a múltiplas drogas na pele de cães com infecção natural por Leishmania (Leishmania) infantum chagasi (Cunha e Chagas, 1937) Shaw, 2002, submetidos a diferentes protocolos de tratamento

Pós-graduação em Medicina Veterinária - FCAV

Avaliação do conhecimento e do grau de satisfação dos usuários em relação à estratégia de saúde da família no município de Pedregulho-SP

Pós-graduação em Serviço Social - FCHS

Cuida e ser cuidado: compreendendo as significações desse processo para famíliares cuidadores e idosos dependentes usuários de um Centro Dia

Pós-graduação em Saúde Coletiva - FMB

Qualidade do serviço público odontológico no Brasil: a percepção de usuários e profissionais da saúde

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

As dimensões internacionais das políticas brasileiras de combate ao tráfico de drogas na década de 1990

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo comparativo sobre a eficácia de duas drogas de ação anti-inflamatória (Etoricoxib e Diclofenaco) após exodontia de terceiros molares inferiores inclusos.

In this article the authors clinically compare the efficacy of two different anti-inflammatory drugs - Etoricoxib (Arcoxia®) and Diclofenac (Olfen®) – in the control of postoperative pain resulting from the surgical removal of impacted lower third molars. Fifteen patients requiring the extraction of bilaterally impacted lower third molars were selected at the Department of Oral and Maxillofacial Surgery at the Araraquara School of Dentistry – UNESP. The drugs were randomly administered during the first and second surgical procedures. Pain was evaluated by means of a visual analogic scale for 72 hours following the surgical procedure. After statistical analysis of the results, the authors concluded that there were no significant differences in terms of postopoerative pain control between the two drugs studied.

Efeitos de drogas antiplaquetárias na doença periodontal

The association between platelets, angiogenesis and progression or repair of periodontal disease has been little explored and, consequently, the results are inconclusive. The pathogenic bacteria present in the periodontal pocket release endotoxins that affect the endothelial integrity and are able to induce the production of chemical mediators derived from plasma proteins and blood clotting while altering platelet function. There is great interest in the modulation of platelet activity in vascular disorders, especially cardiovascular diseases. For this reason, antiplatelet drugs, that are commonly used in the prevention of thromboembolic diseases, such as myocardial infarction, ischemic stroke and peripheral arterial disease, have been used. Aspirin is the only non-steroidal antiinflammatory agent with antiplatelet activity. In the periodontium, instead of only reduces levels of inflammatory cytokines, also significantly affects bleeding on probing, suggesting a dose-dependent modulation of periodontitis. In contrast, clopidogrel and ticlopidine are thienopyridine drugs with no known antiinflammatory action, suggesting that this benefit is related to an antiinflammatory effect indirectly correlated to their antiplatelet activity already established. In the literature there is limited information about the effect of these drugs on periodontium and periodontal disease development. Antiplatelet drugs hypothetically can change both the pathogenesis of periodontitis and subsequent periodontal tissue repair by blocking the secretion of chemical mediators which in general are important in modulating inflammation and tissue repair.

Desordens temporomandibulares em usuários de prótese parcial removível: prevalência de acordo com a classificação de Kennedy

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Poder soberano e biopolítica no combate às drogas no Brasil

In the last two or three decades has become common the debate on the harmful effects produced by trade and use of illicit substances in Brazil. The "drug problem" as it became known worldwide in official and media discourses, has become, if not the only, at least the most important determinant of a series of social ills that affect both the rich countries (classified as consumers), and the poor countries (the producers and exporters of these "evil substances"). This situation that today is extremely pernicious, may be better understood through some elements of the story of its constitution. In this sense, we draw a succinct history of drug prohibition worldwide and we use the Foucauldian concept of biopower and the concept of “death policy” designed by André Saldanha Costa to comment briefly on the "drug problem" in Brazil. In this initial approach, we can affirm the importance of these two concepts for the understanding of the “depoliticized life" of drug traffickers as well as the governmental policies, both legal and health focused on this issue.

Juventude, drogas e biopolítica

In this article, we tackle the issue of youth and drugs as something linked to biopower and biopolitics, both concepts developed by Michael Foucault. Youth and drugs are taken and analyzed in situations involving the management of crime linked to the risks and deviations from the law, abuse and dependence. The youth; irreverent, courageous, healthy, idealistic, and that wanted to change the world for the better as we have seen in the past, is now strongly related to violence, dangerous activities, moral and social risks, drug addiction, criminality, and others negative images. To deal with these young people, tolerance and small punishments of yore are not enough anymore. The young people emerge as a segment of the population subject to various actions and programs. The drugs now are seen as matters of security and public health. There is a shifting and repositioning in the discourse about the young - from minor, drugged, and criminal to lawbreaker, user and drug addict. The change is subtle, but represents a modulation in the devices of social control. Beyond the consent of the young to get rid of drugs, there is a search for the creation of a wide area of monitoring of their behavior through the activation of community protection networks. The belief that the young are more impressionable and vulnerable, and that action on the cause of the problem or risk reduction are the most efficient ways of management, taking responsibility away from personal and family sphere and transferring it to the State, contributes to the increasing control of young people nowadays.