In vitro antifungal susceptibility of candida albicans isolates from patients with chronic periodontitis and diabetes

Alterations that lead to deficiency of the immune system, such as diabetes mellitus, may promote proliferation of Candida albicans and selection of strains which have greater ability to adhere and to penetrate the host tissues. Recent studies indicate an increase of the antifungal resistance of C. albicans isolates in periodontal pockets, suggesting that the oral cavity could be a reservoir of resistant yeast to antifungal agents. Moreover, oral cavity can act as a reservoir of certain pathogens that may cause systemic infections. The periodontal pocket is an ecological niche suitable to host microorganisms that could act as opportunistic pathogens. The aim of this study is to contribute to the understanding of resistance to conventional antifungal against C. albicans isolates from patients with periodontitis and diabetes. The determination of the minimal inhibitory concentrations (MIC) was evaluated according to M27S3 of the CLSI (2008), with modifications. The results showed that 48.8% of the studied strains were resistant to one or more antifungals and 6.6% were resistant to fluconazole and voriconazole. These results suggest an increasing resistance to conventional antifungal agents among Candida species, suggesting that the oral cavity could host pathogen fungi.

Geoprocessamento de variáveis morfométricas para caracterização da microbacia do Córrego do Petiço

This study aims to perform the morphometric characterization of the watershed stream Petiço, Botucatu-SP, through techniques of GIS by GIS IDRISI Selva and Charter planialtimetric Botucatu (SF-22-ZB-VI-3) , edited by IBGE (1969), scale 1: 50000 for ranking the drainage network and the morphometric analysis. The variables analyzed were the dimensions, the relief pattern, pattern of the drainage network and the shape variables. The results show that related to how the watershed has an oblong shape with environmental interpretation with low tendency to flooding and erosion. The sinuosity index of 1.22 shows that the channels of the micro tend to be somewhat sinuous, which allows to infer that is permeable soil with good water infiltration. Based on the results of the morphometric variables was found that the watershed is in good condition of conservation, however, presents certain risks of susceptibility to erosion, and environmental degradation in some points, being fundamental to the maintenance of vegetation cover, in view of the roughness coefficient (Rn). Thus, the evaluation of morphometric characteristics in the study watershed constitutes an important tool in conjunction with the use of GIS and Geographic Information Systems makes possible the planning and management of natural resources aimed at their conservation.