189 resultados para Agentes antirretrovirais - Teses


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The Family Health Strategy facilitates user access to mental health actions. This study aimed to verify the community health agents’ perceptions of the Family Health Strategy about mental disorder. A qualitative study was conducted with 26 randomly selected community health agents, among the professionals of 13 units, which constitute the Family Health Strategy of Itapeva (SP). The community health agents responded to a personal information questionnaire and a semi-structured interview. Data were checked through content analysis. Stigmatizing perception of the mentally disturbed persons, lack of knowledge about the process of falling ill and the mental disorder evolution, and the unpreparedness to act in this population were observed. Capacitating agents enable them to contribute in a positive way to the effective functioning of a care net in mental health in the city.

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Introduction: Low back pain is characterized as a musculoskeletal disorder responsible for loss of productivity and high absenteeism of the affected individuals. Objectives: To analyze the effects of short-and long-term program of health education and therapeutic exercise in relation to quality of life, flexibility and pain intensity of community agents in Marilia city, Sao Paulo, Brazil. Methods: A total of 17 women community workers (40.29+9.97 years) were analysed. Evaluations were made in relation to quality of life, flexibility and intensity of pain before, immediately and 30 weeks after the intervention. Results: We observe the positive results of programs in six domains of quality of life questionnaire and flexibility in the short-and long-term (p<0.005). The intensity of pain showed significant reduction only in the short-term. Conclusion: The methodology used was able to improve the quality of life, flexibility and reduce pain intensity of community agents.

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The Assistive Technology makes the lives of people without disabilities more practical, but for people with disabilities it can make things possible. For these individuals can provide the conditions, making their limitations are not obstacles to their social and personal empowerment, and may contribute to their effective participation in tasks that were previously impossible, such as remaining seated correctly. A segment on which the necessary assistive technology works, is the adaptation of furniture such as chairs, tables, chairs-to-wheels for individuals with disabilities, as well as cerebral palsy. The study aimed to conduct a survey and brief description of theses and dissertations produced in Brazil on furniture adapted for students with cerebral palsy. We made searching in databases of libraries of major universities and federal state national banks, theses and dissertations. Nine studies were selected for description. It was concluded that there is a considerable array of professionals, both in engineering as the field of rehabilitation, to contribute in the adaptation, creation and even the manufacture of furniture for children with cerebral palsy and that the securities most studied are the chairs and their components.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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O câncer colorretal (CCR) é a terceira causa mais comum de câncer no mundo em ambos os sexos e a segunda causa em países desenvolvidos. Seu tratamento convencional é baseado na cirurgia associada à radioterapia e à quimioterapia em dose máxima tolerável, para tentativa de eliminação massiva das células tumorais. Tal abordagem, no entanto, pode causar efeitos colaterais importantes, entre eles as alterações hematopoiéticas e a supressão da resposta imune. As vacinas de células dendríticas mostram-se como opção terapêutica promissora para muitos tipos de câncer, havendo diferentes protocolos de preparação e sensibilização dessas células para dirigir a resposta antitumoral específica. Alguns agentes antineoplásicos em doses ultrabaixas mostraram modular positivamente as células dendríticas (DCs) e, na célula tumoral, promover alterações na transcrição de vários genes imunologicamente relevantes. Considerando que, em estudos prévios, tais mudanças transcricionais resultaram em aumento de imunogenicidade das células tumorais, hipotetizamos que o RNA das células pré-tratadas deve ser mais eficiente do que o RNA das células originais para preparação de vacinas de células dendríticas. Assim, objetivamos avaliar se o tratamento de células do tumor de cólon humano (HT-29) com PAC ou 5-FU/LEUCO torna seu RNA mais eficiente para preparação dessas vacinas. Para essa investigação, DCs humanas geradas a partir de monócitos de sangue periférico foram transfectadas com RNA total das células tumorais pré-tratadas e, a seguir, testadas quanto à capacidade de apresentação de antígenos e indução de células T citolíticas específicas. Apesar da baixa viabilidade celular pós eletroporação, os resultados obtidos sugerem que o tratamento de células tumorais com concentrações não tóxicas de 5-FU ou PAC promove alteração de expressão... (Resumo completo, clicar acesso eletrônico abaixo)

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The research aims to analyze the main changes in the concepts of the processes of production and consumption of news content information. The theoretical framework used will be the new consequent social, economic and technological paradigms of the current scenario of convergence of platforms, content and languages. The research aims to investigate the changes in the macro environment of journalistic production and, therefore, examine whether the local flow of news content meets the requirements of a new public consumption target set by the new Brazilian generations, composed of young people influenced by the cultures of computing, audiovisual communication and also by economic and cultural globalization. As expansion of the analyzes sought to verify the impact of these changes in the current models of traditional media, as well as the interference caused and trends in models of existing production. Also a case study is performed on this production flow in comparison with current market research of Jornal da Cidade (JC) of the city of Bauru (SP), the main media of the Grupo Comunicação. The intent of the approach will be to establish some preambles to assist in bringing the theory with the practical impacts on journalistic production, its agents, institutions and the workplace

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O presente trabalho apresenta em sua essência conceitos relacionados as práticas de Governança Corporativa no mundo e, principalmente, no Brasil. Tais práticas são leis que ajudam na Bolsa de Valores, trazendo mais transparência e confiança para os agentes e está desenvolvido no segundo capítulo. Tais práticas, então, afetarão diretamente as expectativas dos agentes a investirem seus capitais de forma mais segura. Para tanto, é necessário ter uma ideia geral de como são afetadas tais expectativas e é onde está desenvolvido o primeiro capítulo. Para concluir, é feita uma análise empírica, baseada em séries temporais, de econometria para auxiliar se o que a teoria nos diz é comprovada na prática e são usadas como base os Bancos Nossa Caixa e Banco Bradesco

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Our previous studies have shown that low concentrations (noncytotoxics) of antineoplastic agents modulate positively the dendritic cells, favoring their in vitro maturation and improving their antigen presenting function. The effects on colorectal cancer cells (HCT-116) were also investigated and we have observed an increased immunogenicity and susceptibility to cytotoxic T cells. Thereby, this study aimed to investigate the effect of 5-fluorouracil (5-FU) an azacitidine (AZA), in minimum effective and noncytotoxic concentrations on lymphocytes of healthy donors. In this study we have analyzed the cytotoxic effect of drugs at these concentrations as well as the proliferative ability of lymphocytes. In vitro production of IL-10 and IFN-γ has been also evaluated. We have observed that low concentrations of those chemotherapeutic agents are not cytotoxic for lymphocytes. However, the minimum effective concentrations (5-FU: 0,410±0,088 e AZA: 0,757±0,233; p<0, 05) have reduced the cell number. Proliferative activity of allogeneic lymphocytes in a mixed reaction (MLR) was not affected by the treatment. The cytokine production was not affected by the treatments, either. In conclusion, low concentrations of 5-FU and AZA has no deleterious effects on human peripheral blood lymphocytes and seems to be safe for combinatory administration with DC vaccines

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em História - FCHS

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Pós-graduação em Educação Escolar - FCLAR