Diferenças funcionais das regiões hipocampais na formação da memória do tipo o quê", "quando" e "onde" em ratos

Episodic memory refers to the recollection of what, where and when a specific event occurred. Hippocampus is a key structure in this type of memory. Computational models suggest that the dentate gyrus (DG) and the CA3 hippocampal subregions are involved in pattern separation and the rapid acquisition of episodic memories, while CA1 is involved in memory consolidation. However there are few studies with animal models that access simultaneously the aspects ‗what-where-when . Recently, an object recognition episodic-like memory task in rodents was proposed. This task consists of two sample trials and a test phase. In sample trial one, the rat is exposed to four copies of an object. In sample trial two, one hour later, the rat is exposed to four copies of a different object. In the test phase, 1 h later, two copies of each of the objects previously used are presented. One copy of the object used in sample trial one is located in a different place, and therefore it is expected to be the most explored object.However, the short retention delay of the task narrows its applications. This study verifies if this task can be evoked after 24h and whether the pharmacological inactivation of the DG/CA3 and CA1 subregions could differentially impair the acquisition of the task described. Validation of the task with a longer interval (24h) was accomplished (animals showed spatiotemporal object discrimination and scopolamine (1 mg/kg, ip) injected pos-training impaired performance). Afterwards, the GABA agonist muscimol, (0,250 μg/μl; volume = 0,5 μl) or saline were injected in the hippocampal subregions fifteen minutes before training. Pre-training inactivation of the DG/CA3 subregions impaired the spatial discrimination of the objects (‗where ), while the temporal discrimination (‗when ) was preserved. Rats treated with muscimol in the CA1 subregion explored all the objects equally well, irrespective of place or presentation time. Our results corroborate the computational models that postulate a role for DG/CA3 in spatial pattern separation, and a role for CA1 in the consolidation process of different mnemonic episodes

Para onde sopram os ventos :politicas públicas de turismo no grande Pirambu/Fortaleza/CE

PARA ONDE SOPRAM OS VENTOS , metaphor used to indicate turism public politicsway to the west zone of Fortaleza, against the direction where until now this public politics was targeted, to the east zone. This context, análise the public politics implemented in the Grande Pirambu, so like the processes of nonterritorialization and reterritorialization unchain by the program os settlement and indemnification of the Projeto Costa Oeste. Aim to learn the transformations that unroll in the studied área, based in proceding methodologic that privileged the interviews with many social actors resettled, indemnificators, intirenants, livers and fishmen. The public politics analyzes run to the Grande Pirambu infer that the same answer at trying of urbam requalification of the área, object of the new exigence pretender by the touristics activities developed in Fortaleza, wish to incorporate this área at the turistics dynamic of the city. However, the implementation of the Projeto Costa Oeste do not occuring in calm way, by opposite sence the beginning, the same has been propitiated polemics and discussions, stired up about public politics between the municipa and state power, to bring about injury in the public coffers, to the developing turismo f the city and, mainly to the living around Grande Pirambu, unquiet and sad with the buildings of the referring project that there is running for four years

Onde fica o sertão rompem-se as águas: processo de territorialização da ribeira do Apodi-Mossoró (1676-1725)

The Portuguese territorial process of the captaincy of Rio Grande was initiated in1598 with the conquest of the Potengi River bar by Mascarenhas Homem. This process lasted until 1633, when it was interrupted by the arrival of the Dutch, and resumed only in 1654. From this year on, the occupation of unknown lands of the captaincy was encouraged, supporting the advancement towards conquering the backlands, breaking the divisive boundaries with the captaincy of Siará Grande so far known: the Assú riverside. This breakthrough resulted in confrontations with the inhabitants of these lands, known as tapuias, leading to outbreak of several conflicts that composed the Barbarians War. The main stage of such events in Rio Grande, between the years 1687 and 1720, was precisely the Assú riverside, one of the spaces to be investigated by this research. Therefore, this paper aims to analyze the advance of the conquerors in Rio Grande, contributing to the territorial process, which resulted in the emergence of a new border between Rio Grande and Siará Grande: the Apodi-Mossoró river. For this purpose, it was used sources produced between the years 1659 and 1725, as the settlement letters, royal charters, correspondence between the City Council of Natal, captains of Rio Grande and the government of Pernambuco and also the general government, as well as the documents related to the militia composed mainly by Paulistas who struggled in the captaincy.