Agregação familiar e resultados maternos e perinatais da pré-eclâmpsia severa em população do Rio Grande do Norte

To determine whether there is familiar aggregation of severe preeclampsia in a Brazilian population from Rio Grande do Norte and to characterize the maternal and perinatal outcomes in the studied population. Methods: A case control study was performed with 412 participants who were admitted at Maternidade Escola Januário Cicco (MEJC) for medical care. Of these, 264 subjects presented normal blood pressure and 148 were cases. Cases were composed of eclampsia (n=47), HELLP Syndrome (n=85) and Eclampsia associated with HELLP syndrome (n=16). The diagnosis of these illness were based on the citeria developed by National High Blood Pressure Education Program Working (2000). An interview was performed with each subject and questions related to personal and familiar history of hypertension, preeclampsia, HELLP syndrome and eclampsia. Statistical analysis was performed and comparison of median and mean between cases and controls were performed, with the level of significance of 5%. The Odds-Ratio was determined to estimate the risk of preeclampsia within the families. Results: There were no difference in the demographic data between cases and controls. Previous history of chronic hypertension and preeclampsia was more frequent in the case group. Headaches were more frequent in eclampsia and epigastric pain in the HELLP syndrome cases. Bleeding and oliguria were more frequently found in the eclampsia associated with HELLP syndrome cases. Acute Renal insufficiency was a common complication in the case group, but these cases did not evolve to chronic renal insufficiency. The maternal mortality was 0.4% and the perinatal mortality was high, 223 per 1,000 live births. The 111 risk of a woman to develop preeclampsia whose mother has hypertension or had preeclampsia was respectively 2.5 and 3.5. This risk was increased 5 times, when a sibling has hypertension and 6 times when both sibling and mother had previous history of preeclampsia. Conclusions: This study confirms that there is familiar aggregation of preeclampsia in this Brazilian population. The potential for cardiovascular complications due to development of chronic hypertension indicates the need of closely follow up of women who develop preeclampsia

Processos carioevolutivos na ordem tetraodontiformes: uma visão através de suas diferentes linhagens

Given the great diversity of fishes, the Order Tetraodontiformes stands to show genetic and morphological characteristics enough singular. The fishes of this order have a compact DNA which favors molecular studies, as well as comparisons with more basal species. Model of genome evolution, there are still many gaps in knowledge about their chromosomal patterns and how evolutionary rearrangements influence the marked variation in DNA content of this order. In view of this, we present cytogenetic analyzes of the species Acanthostracion quadricornis (Ostraciidae), A. polygonius (Ostraciidae) Melichthys niger (Balistidae) Cantherhines macrocerus (Monacanthidae) and C. pullus (Monacanthidae), Lagocephalus laevigatus, Colomesus psittacus and Canthigaster figueiredoi (Tetraodontidae), to contribute with cytogenetic data for this group. The analysis was performed by C-banding, Ag-RONs, coloring with base-specific fluorochromes DAPI-CMA3, restriction enzymes AluI, EcoRI, TaqI, PstI and HinfI and in situ hybridization with probes for ribosomal DNA 18S and 5S. The heterochromatic ultrastructure of A. quadricornis and A. polygonius revealed a outstanding heterochromatin content, which may indicate that the accumulation or loss of extensive heterochromatin content could be responsible for large variations in genomic content displayed in different Tetraodontiformes families. The species Cantherhines macrocerus, C. pullus (Monacanthidae) and Melichthys niger (Balistidae) shows a huge karyotypic similarity both numerically and structural. L. laevigatus showed similar cytogenetic features (2n = 44 and single RONs) to the species of the genus Takifugu, which reinforces the idea of their phylogenetic relationships. C. psittacus presented the highest diploid number described for the family (2n = 56) and large amount of HC, features that related with its sister family Diodontidae. Cytogenetic analysis in C. figueiredoi revealed heterochromatic polymorphisms, RONs multiple and Bs chromosomes. These events are rare in marine fishes, and are possibly associated with the strong restructuring and genomic reduction that this family has been suffered. These features, plus the morphological and molecular data suggests that these species share the same ancestral branch, with a possible monophyletic origin. In this study, new contributions to the knowledge of evolutionary patterns facing by Tetraodontiformes are provided and discussed under cytotaxonomyc, genomic and evolutionary perspectives.

Análise crítica da (des)(re)construção identitária em produções de narrativas de mulheres vítimas de violência de gênero

La violence a été utilisée comme un outil de maintenance du système patriarcal qui hante encore notre société. In séré et légitimé dans / par notre culture, le régime patriarcal considère la femme comme un être inférieur qui doit être subjugué et maîtrisé, y compris par la force. Cette recherche a pour d'étudier, dans les pratiques discursives et sociales, les process us de (dé) (re)construction de l’identité dans les productions de récits de femmes victimes de violence sexiste. Par conséquent, nous nous efforcerons de vérifier les études d'autres domaines tels que les études culturelles, la sociologie, le féminisme, en tre autres. De ce fait, nous croyons que ce mémoire se trouve dans les études de Linguistique Appliquée et dispose d'un point de vue interdisciplinaire (MOITA - LOPES, 2006), en plus des domaines énumérés, nous utiliserons l’analyse critique du discours, la sociologie pour le changement social et linguistique systémique fonctionnelle. Pour l'analyse autour de la posture interdisciplinaire en Linguistique Appliquée, on utilise la méthodologie qualitative/ interprétative (Magalhães, 2001). Afin d'examiner les r écits du «je» de femmes victimes de violence, nous nous sommes servie des récits exposés sur Internet, puisqu'ils sont du domaine public. Ainsi, nous avons étudié que les rapports trouvés sur l’outil « commentaire » présents dans les rapports du site G1, p lus spécifiquement, les rapports sur la violence de genre réalisés en 2014 dans deux villes du nord - est : Piauí et Rio Grande do Norte, et dans une déclaration faite dans le programme "Profession Reporter" en 2011. Pour asseoir notre recherche, comme une m éthode d'étude et de théorie sociale, nous utilisons l'Approche Sociologique Communicationnel du Discours, courant lié aux hypothèses de l’Analyse Critique du Discours (Pedrosa, 2012a). Les données montrent que les récits du «je» dans l'outil «commentaire» sont divisés en deux groupes principaux: les récits de renonciation et les récits de persistance. Nous réalisons également que les sujets se déplacent dans les sphères d'identité selon leurs contextes narratifs. La recherche nous a permis de déduire enco re qu'il y a une possibilité de changement social à partir de la narrativisation des tensions identitaires et la reconnaissance des inégalités dans les relations de pouvoir.