Preparação e caracterização de sistemas emulsionados lipidicos contendo praziquantel

Praziquantel (PRZ) is the main drug used for treatment of schistosomiasis in Brazil. It is administered by oral rout as tablets. However, has low aqueous solubility which limits this therapeutic success dosage form and availability of liquid forms. The emulsion systems have great potential and represent an interesting strategy to increase the solubility of drugs. The aim of study was the development and characterization of lipid-emulsified liquid systems of the type oil in water (O / W), the base of soybean oil as the internal phase stabilized by surfactants pair Tween® 80 and Span® 80, for improving the phase biopharmaceutical of PRZ. After selecting the best value of Hydrophilic-Lipophilic Balance (HLB = 11), the parameters of the preparation of the formulations were optimized emulsification technique. The emulsions were successfully obtained; the liquid forms provided exhibited Newtonian behavior and an increase in solubility of PRZ higher than 20 times. The accelerated stability study demonstrated the stability of the emulsions and the effect of cosurfactants investigated. The study of the dynamics of interaction between components in the diagram showed pseudoternary phase regions to obtain O/W emulsions, whereas the study of the interaction of the components and their effect on system structure and the efficiency of incorporation of the drug led to systems with an amount of soluble drug even higher (about 1.5%), which demonstrates the potential of this new input mainly for the treatment of schistosomiasis, which resulted in the filing of patent BR 10 2013 0004 55 3

Diálogos com o homem imaginário: pensando o uso de imagens no ensino de sociologia

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

A guerra midiática contra a Venezuela de Hugo Chavez: a cobertura da revista veja (1998-2002)

A pretensão deste trabalho foi o de analisar o discurso da revista semanal Veja sobre o governo de Hugo Chávez Frías, atual presidente da República Bolivariana da Venezuela. Através da leitura das reportagens, procuramos apresentar o comportamento da revista em relação ao se governo e a forma que sua política é classificada, representada. Reunimos edições da revista, entre 1998 a 2002, início do seu governo - eleito em dezembro de 1998, toma posse no início de 1999, período da tentativa de golpe (frustrada) em abril de 2002. O trabalho procura mostrar como as matérias não são isentas e que há um claro posicionamento ideológico da revista, que se insere no conjunto mais geral da mídia conservadora e anti-Chávez. O presidente, eleito e reeleito democraticamente, aparece sempre nas diversas reportagens da revista caracterizado como golpista, ditador, populista, fanfarrão. O nosso objetivo é o de revelar como Veja criou uma imagem negativa do presidente da Venezuela, coerente com os princípios neoliberais defendidos pela revista. A Venezuela com Hugo Chávez, com a chamada Revolução Bolivariana , realiza uma experiência singular de governo num país de larga tradição antidemocrática e afirma caminhar na contracorrente do pensamento hegemônico neoliberal. Em contrapartida, a revista Veja se apresenta com um representante da burguesia financeira e importante sujeito na construção e continuidade do neoliberalismo

Albuns fotográficos de/por Enoque Neves: uma poética visual

La imagen fotográfica la imagen despierta pulsiones, en una experiencia provocativa que acciona el campo mítico-fenomenológico descíframe o te devoro . El texto fotográfico no constituye sólo un momento del real , es mucho más que un recorte gélido del tiempo pasado. Sobretodo, porque la comprensión del lenguaje subyacente a la imagen fotográfica se coloca dentro y más allá de lo meramente dado y/o objetivado . En la comprensión de la imagen se disponen regímenes de subjetivación horadado por códigos culturales, dominios del lenguaje, símbolos, experiencias estéticas, creación simbólica, valores, memorias, imaginarios. En ese sentido, surge el estudio, el levantamiento y la sistematización del acervo fotográfico dejado por el fotógrafo autodidacta: Enoque Pereira das Neves (1918-2002), que produjo formas visuales reveladoras de orientaciones culturales colectivas y universos fotográficos imaginarios. Él fotografió por medio siglo la vida cotidiana del campesino, en tierras potiguares y paraibanas. En la comprensión del acervo opte por subdividirlo en álbumes los cuales revelan las intimidades del fotógrafo con el lugar, una escrita de si, un estado del alma, del sujeto que observa la relación sociedad y naturaleza, en una especie de simbiosis en que accionan potencias resonantes de creación en el devaneo de la materia, sobresaliéndose a la pulsión terrestre, o enraizamiento, os rizomas del hombre unido a la tierra, las tradiciones, a rusticidad, laboral, bien como el apelo estético direccionado al agua: pulsión de vida en tierras áridas. La comprensión del inmenso acervo, evaluado en más de cincuenta mil fotografías es profundamente representativa de predilección temática circunstanciada por la niñez, la narrativa enfoca imágenes míticas como la del Eros nudo, la madona y el niño, y prácticas culturales del universo infantil, como el juguete y el juego. Mismo el acervo siendo un apelo estético a la vida surgió la imagen fotográfica de la muerte, especialmente, la muerte en la niñez o ángel y la muerte de ancianos como o deseo de la última imagen de aquel entre los suyos. La investigación es transversal por los siguientes objetivos: propongo un reconocimiento del acervo de Enoque Pereira das Neves en la intención de comprender el universo imaginario presente en su obra fotográfica. Invisto también, en la posibilidad de hacer la lectura del acervo como álbum imaginario.

Atividades comportamentais e comportamento alimentar de rã touro, Lithobates catesbeianus (Shaw, 1802), de pigmentação normal e albina em cativeiro

The behavior of bullfrogs reared in captivity must be well understood to support management practices that use efficient feeding regimes. In general, bullfrogs reared in captivity have normal pigmentation, but to develop an enhanced product, some studies have investigated the introduction of albino individuals in frog farms. The present study characterized the behavior of both pigmented and albino bullfrogs reared in captivity. In an initial experiment, 48 bullfrogs (70.5 ± 25.6 g) housed in small stalls were fed once a day at random times. Frogs were filmed and the images showed that both the pigmented and albino varieties behaved similarly: food intake was more frequent at dawn followed by light periods; moving and resting in dry areas may be associated to feeding events; frogs appeared to anticipate feeding time and to rest in the water more frequently in periods other than feeding time; daylight is the recommended period for feeding both pigmented and albino frogs. In a second experiment, 72 albino bullfrogs were fed at fixed times (10 a.m. or 4 p.m.) in small stalls. An initial weight of 23.8 ± 7.6 g was considered to evaluate frog performance, and after the animals reached 60.0 ± 20.0 g, they were filmed for behavior analyses. Food intake varied as a function of feeding time, and frogs were more likely to eat during the early hours of the day and immediately after receiving fresh food. Frogs fed only in the afternoon changed their behavior. Food supplied twice a day stimulated the albino frogs to eat at different times, but did not increase growth. Although fresh food stimulated feeding behavior, food intake was more frequent at dawn. Food supplied at this time of day should therefore be further investigated. The results did not indicate a more suitable feeding time (10 a.m. or 4 p.m.) for albino bullfrogs, or any advantage in using two feedings per day. The results provide xvi important information about bullfrogs in terms of food supply regime and activity preferences throughout the day. This novel information will contribute to future studies in this area

CrossMDA2: Uma abordagem para minimizar o problema da fragilidade de pointcuts na evolução de sistemas orientados a aspectos

This work proposes a model based approach for pointcut management in the presence of evolution in aspect oriented systems. The proposed approach, called conceptual visions based pointcuts, is motivated by the observation of the shortcomings in traditional approaches pointcuts definition, which generally refer directly to software structure and/or behavior, thereby creating a strong coupling between pointcut definition and the base code. This coupling causes the problem known as pointcut fragility problem and hinders the evolution of aspect-oriented systems. This problem occurs when all the pointcuts of each aspect should be reviewed due to any software changes/evolution, to ensure that they remain valid even after the changes made in the software. Our approach is focused on the pointcuts definition based on a conceptual model, which has definitions of the system's structure in a more abstract level. The conceptual model consists of classifications (called conceptual views) on entities of the business model elements based on common characteristics, and relationships between these views. Thus the pointcuts definitions are created based on the conceptual model rather than directly referencing the base model. Moreover, the conceptual model contains a set of relationships that allows it to be automatically verified if the classifications in the conceptual model remain valid even after a software change. To this end, all the development using the conceptual views based pointcuts approach is supported by a conceptual framework called CrossMDA2 and a development process based on MDA, both also proposed in this work. As proof of concept, we present two versions of a case study, setting up a scenario of evolution that shows how the use of conceptual visions based pointcuts helps detecting and minimizing the pointcuts fragility. For the proposal evaluation the Goal/Question/Metric (GQM) technique is used together with metrics for efficiency analysis in the pointcuts definition

Função quadrática

In general, the study of quadratic functions is based on an excessive amount formulas, all content is approached without justification. Here is the quadratic function and its properties from problems involving quadratic equations and the technique of completing the square. Based on the definitions we will show that the graph of the quadratic function is the parabola and finished our studies finding that several properties of the function can be read from the simple observation of your chart. Thus, we built the whole matter justifying each step, abandoning the use of decorated formulas and valuing the reasoning