Efeitos do treinamento aeróbio sobre sinais precoces do remodelamento do ventrículo esquerdo induzido pelo diabetes Mellitus experimental

Our aim was to investigate the effects of an aerobic training program on adverse and early left ventricle (LV) remodeling, using an experimental model of short-term type 1 diabetes (T1D). Wistar rats were divided in 4 groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD) and trained diabetic (TD). T1D was induced by streptozotocin (45 mg/kg). The training program consisted of 4 weeks running on a treadmill (13 m/min, 60 min/day, 5 days/week). At the end of the experiments, hearts were collected for analysis of morphology and transcriptional profile of LV, by focusing on its remodeling. Deaths were recorded during the 4-week period. We verified high mortality among animals of DS group, whereas it was significantly reduced in DT group. DS group also showed an increase in cross-sectional area of cardiomyocytes and fibrosis. TD group exhibited reduction in measures of cardiac trophism, but with respect to collagen content, it was similar to CS group. Analysis of gene expression related to cardiac remodeling revealed decreased expression of collagen I and III, as well as low expression of MMP-2 in DS group. TD group showed decreased levels of mRNA for MMP-9, and unchanged gene expression of MMP-2 when compared with the CS group. The expression of MMP-2 and TGF-1 were increased in CT group. The ratio between gene expression of collagen I and III was increased in the CT group and decreased in diabetic groups. These results establish early changes of the structure and transcriptional profile of LV myocardium. Moreover, they indicate that aerobic exercise training plays specific protection against mechanisms responsible for cardiac damage observed in T1D

O efeito da dessincronização circadiana sobre o metabolismo

The lost of phase relationship between rhythms and behaviour can, and often do, undesirable consequences. The purpose os study was to ascertain the effect of circadian desynchronization in T22 about metabolism of wistar rats. The subjects consisted of 24 animals separated in two groups: control (n=12) T24 with 8 weeks of aged and experimental group (n=12) T22, also with 8 weeks of aged. Both the groups were subject to register of locomotor actitivity, body temperature, body weight and food intake in all the experiment. And more, both the groups were subject to food deprivation, running in treadmill and forced swimming. The results show rhythm of locomotor activity and body temperature desynchronized. Dont exist diference in body weight between both the groups (T24 = 386,75±40,78g e T22 380,83±44,28g) . However, the food intake was different between the phases, light and dark, in intergroup and intragroup. The body temperature was not different in food deprivation. The same ocurred for running in treadmill and forced swimming. Since similar alterations occur in shift workers, it is proposed that the experimental paradigm presented in this manuscript is a useful model of shift work. That is, alterations in activity/rest cycles and consummatory behavior can affect the health of organism

Relação entre o ciclo sono e vigília e a função cardiorrespiratória em estudantes de medicina

Students, normally, present an irregular sleep pattern characterized by delays in sleep onset and offset from weekdays to weekends, short sleep duration on weekdays and long sleep duration on weekends. The reduction of the necessary sleep and the irregularity in the sleep patterns provoke relevant short- and long-term impairments on performances, for example, in cardiorespiratory function. The cardiorespiratory performance represents, in addition to fitness, traces associated to health conditions and in several studies to pattern and/or individual s sleep quality. The aim of this study was to evaluate the pattern of the sleep-wake cycle and the cardiorespiratory function of medical students under different class schedules. The study was accomplished with two classes of medical students of UFRN, one had classes at 7 am (n = 47) and the second had classes at 8 am (n = 41) during the week. On the first stage of the study all volunteers filled out an anamnesis, the International Physical Activity questionnaire, the Pittsburgh index of sleep quality, the Portuguese version of the Horne and Östberg cronotype questionnaire, the Health and Sleep questionnaire and the Epworth Scale of Somnolence (ESS). On the second stage, 24 students (12 of each class) had their activity rhythm monitored by actimeters set to record activity at a 2-min interval for 14 days concomitant to the completion of the sleep diary. In this same stage, each volunteer performed the effort test (treadmill) only once in the morning period (between 9:00 and 11:00). The students showed an irregular pattern of the sleep-wake cycle and this irregularity is strongly influenced by the class schedules, in addition to the contribution of the academic demand, social activities and endogenous factors. The students who woke up earlier showed greater irregularity in the sleep-wake pattern. The earlier was the class schedule the worse was the sleep quality and the greater was the frequency of students with excessive diurnal somnolence. The classes schedules and the irregular pattern of the sleep-wake cycle did not show effect on the cardiorespiratory performance of the medical students. The performance on the test seems to be affected by other factors, which can be related to the pattern of the sleep-wake cycle or not. Therefore, it is suggested that the late start of classes provokes less irregularity on the pattern of the sleep-wake cycle. However, it was observed that this irregularity and the class schedule seem not to affect the cardiorespiratory performance directly

Os possessivos de segunda pessoa em cartas de leitores de jornais brasileiros dos séculos XIX e XX

Based on the theoretical and methodological presuppositions of the theory of language variation and change (cf. WEINREICH; LABOV; HERZOG, 2006 [1968]), it is described and analyzed in this article the process of variation/change concerning the second person possessive pronouns in letters from readers of Brazilian newspapers from the XIX and XX centuries. These letters feature a portrait of the Brazilian press from the South (Santa Catarina), Southeast (Rio de Janeiro) and Northeast (Bahia and Rio Grande do Norte) regions in each century and are part of the Project for Brazilian Portuguese History‘s (PHPB) printed common minimal corpus. The point of departure of this work is the idea that the use of variant forms of expressing second person possessive pronouns – teu and seu – results from the interaction characterizing the varied social roles performed by the letters‘ senders. Arranging communicative units, which gather elements/features denoting time and space, conditioned and determined by socio-historical and cultural aspects, the readers‘ letters, turn out to be a promising research field under the light of this paper. More specifically, In the row of presented results in studies about the pronominal system in the diachroneity of/in Brazilian Portuguese (PB) (FARACO, 2002; LORENGIAN-PENKAL, 2007; CALLOU; LOPES, 2003; LOPES; DUARTE, 2003; MENON, 2005; ARDUIN; COELHO, 2006; LOPES, 2009; MARCOTULIO, 2010), the results featured in here point at different usages of the possessives, noticing the coexistence of the forms teu/tua and seu/sua strongly conditioned by the socio-discursive nature of the readers‘ letters in the course of the centuries and through different regions.

Os possessivos de segunda pessoa em cartas de leitores de jornais brasileiros dos séculos XIX e XX

Based on the theoretical and methodological presuppositions of the theory of language variation and change (cf. WEINREICH; LABOV; HERZOG, 2006 [1968]), it is described and analyzed in this article the process of variation/change concerning the second person possessive pronouns in letters from readers of Brazilian newspapers from the XIX and XX centuries. These letters feature a portrait of the Brazilian press from the South (Santa Catarina), Southeast (Rio de Janeiro) and Northeast (Bahia and Rio Grande do Norte) regions in each century and are part of the Project for Brazilian Portuguese History‘s (PHPB) printed common minimal corpus. The point of departure of this work is the idea that the use of variant forms of expressing second person possessive pronouns – teu and seu – results from the interaction characterizing the varied social roles performed by the letters‘ senders. Arranging communicative units, which gather elements/features denoting time and space, conditioned and determined by socio-historical and cultural aspects, the readers‘ letters, turn out to be a promising research field under the light of this paper. More specifically, In the row of presented results in studies about the pronominal system in the diachroneity of/in Brazilian Portuguese (PB) (FARACO, 2002; LORENGIAN-PENKAL, 2007; CALLOU; LOPES, 2003; LOPES; DUARTE, 2003; MENON, 2005; ARDUIN; COELHO, 2006; LOPES, 2009; MARCOTULIO, 2010), the results featured in here point at different usages of the possessives, noticing the coexistence of the forms teu/tua and seu/sua strongly conditioned by the socio-discursive nature of the readers‘ letters in the course of the centuries and through different regions.