Onde fica o sertão rompem-se as águas: processo de territorialização da ribeira do Apodi-Mossoró (1676-1725)

The Portuguese territorial process of the captaincy of Rio Grande was initiated in1598 with the conquest of the Potengi River bar by Mascarenhas Homem. This process lasted until 1633, when it was interrupted by the arrival of the Dutch, and resumed only in 1654. From this year on, the occupation of unknown lands of the captaincy was encouraged, supporting the advancement towards conquering the backlands, breaking the divisive boundaries with the captaincy of Siará Grande so far known: the Assú riverside. This breakthrough resulted in confrontations with the inhabitants of these lands, known as tapuias, leading to outbreak of several conflicts that composed the Barbarians War. The main stage of such events in Rio Grande, between the years 1687 and 1720, was precisely the Assú riverside, one of the spaces to be investigated by this research. Therefore, this paper aims to analyze the advance of the conquerors in Rio Grande, contributing to the territorial process, which resulted in the emergence of a new border between Rio Grande and Siará Grande: the Apodi-Mossoró river. For this purpose, it was used sources produced between the years 1659 and 1725, as the settlement letters, royal charters, correspondence between the City Council of Natal, captains of Rio Grande and the government of Pernambuco and also the general government, as well as the documents related to the militia composed mainly by Paulistas who struggled in the captaincy.

Expressão de MMPs, marcadores angiogênicos e proliferação celular em tumores odontogênicos

INTRODUCTION AND OBJECTIVE: The study of biological behavior of odontogenic lesions is essential to the establishment of appropriate therapeutic approach and prognosis. The production of extracellular matrix metalloproteinases (MMPs), angiogenesis and cell proliferation contribute to tumor growth. This paper aims to review the literature on odontogenic tumors (OT) selected according to the new World Health Organization classification (WHO- 2005) by evaluating the expression of MMPs, angiogenic and cell proliferation. Furthermore, it aims to verify the relation between these markers and the biological behavior of these lesions. RESULTS: it was found that MMPs -1, -2, -7, -9 and -26 had a higher expression in both epithelial component and stroma, and 13 particularly in the stroma. Increased angiogenesis was observed in more aggressive OT. CD105 expression was higher in keratocystic odontogenic tumour (KOT) and CD34 in solid ameloblastomas (SA). It was observed a higher expression of Ki-67 and p53 in SA and KOT and a low cell proliferation rate in the adenomatoid odontogenic tumour (AOT). CONCLUSION: These results show that MMPs are involved in invasion and recurrence of some odontogenic lesions and are associated with the biological behavior of these tumors. Angiogenesis is critical to provide support to cell proliferation and these concomitant events are correlated with different levels of biological behavior in OT when compared to odontogenic cysts, hence the use of angiogenic inhibitors may be a potential therapeutic approach in these lesions.

Expressão de MMPs, marcadores angiogênicos e proliferação celular em tumores odontogênicos

INTRODUCTION AND OBJECTIVE: The study of biological behavior of odontogenic lesions is essential to the establishment of appropriate therapeutic approach and prognosis. The production of extracellular matrix metalloproteinases (MMPs), angiogenesis and cell proliferation contribute to tumor growth. This paper aims to review the literature on odontogenic tumors (OT) selected according to the new World Health Organization classification (WHO- 2005) by evaluating the expression of MMPs, angiogenic and cell proliferation. Furthermore, it aims to verify the relation between these markers and the biological behavior of these lesions. RESULTS: it was found that MMPs -1, -2, -7, -9 and -26 had a higher expression in both epithelial component and stroma, and 13 particularly in the stroma. Increased angiogenesis was observed in more aggressive OT. CD105 expression was higher in keratocystic odontogenic tumour (KOT) and CD34 in solid ameloblastomas (SA). It was observed a higher expression of Ki-67 and p53 in SA and KOT and a low cell proliferation rate in the adenomatoid odontogenic tumour (AOT). CONCLUSION: These results show that MMPs are involved in invasion and recurrence of some odontogenic lesions and are associated with the biological behavior of these tumors. Angiogenesis is critical to provide support to cell proliferation and these concomitant events are correlated with different levels of biological behavior in OT when compared to odontogenic cysts, hence the use of angiogenic inhibitors may be a potential therapeutic approach in these lesions.

Aqui, desde sempre

Este livro traz novos artigos publicados n’O Jornal de Hoje, depois daqueles publicados em Mais Notícias Genealógicas do Rio Grande do Norte. Acrescento outros artigos que postei no meu blog e outros mais que compus especialmente para esta edição. Devido ao espaço limitado que tenho no jornal, complementei alguns artigos, quando necessário, com algum comentário. Também eliminei informações que só eram necessárias para a publicação no referido jornal. As principais fontes desses artigos foram os documentos da Cúria, das Casas Paroquiais do Assú, de Angicos e de Macau, do Instituto Histórico e Geográfico do Rio Grande do Norte, do Instituto Arqueológico, Geográfico e Histórico de Pernambuco, dos Fóruns de Assú e de Macau, do Museu José Elviro, da Hemeroteca Nacional e dos documentos digitalizados da UNB. Além disso, algumas informações vieram de colegas pesquisadores.

Ampliando o acesso livre a informação: a digitalização do acervo do Núcleo Temático da Seca

FREIRE, Isa Maria, et al. Ampliando o acesso livre a informaçao: a digitalizaçao do acervo do Nucleo Tematico da Seca. Pesquisa Brasileira em Ciência da Informação e Biblioteconomia, v.3, n.2, p. 137-142, 2008.Disponivel em: . Acesso em: 04 nov. 2010.