1 resultado para Synchronized parade
em Digital Archives@Colby
Filtro por publicador
- Repository Napier (1)
- Academic Research Repository at Institute of Developing Economies (1)
- Acceda, el repositorio institucional de la Universidad de Las Palmas de Gran Canaria. España (3)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (8)
- AMS Tesi di Laurea - Alm@DL - Università di Bologna (5)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (11)
- Archimer: Archive de l'Institut francais de recherche pour l'exploitation de la mer (1)
- Archive of European Integration (3)
- Aston University Research Archive (16)
- Avian Conservation and Ecology - Eletronic Cientific Hournal - Écologie et conservation des oiseaux: (1)
- B-Digital - Universidade Fernando Pessoa - Portugal (1)
- Biblioteca de Teses e Dissertações da USP (1)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (9)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (36)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (29)
- Brock University, Canada (7)
- Bucknell University Digital Commons - Pensilvania - USA (1)
- CentAUR: Central Archive University of Reading - UK (11)
- Cochin University of Science & Technology (CUSAT), India (3)
- Comissão Econômica para a América Latina e o Caribe (CEPAL) (1)
- Consorci de Serveis Universitaris de Catalunya (CSUC), Spain (19)
- Cor-Ciencia - Acuerdo de Bibliotecas Universitarias de Córdoba (ABUC), Argentina (1)
- CORA - Cork Open Research Archive - University College Cork - Ireland (1)
- Corvinus Research Archive - The institutional repository for the Corvinus University of Budapest (2)
- Digital Archives@Colby (1)
- Digital Commons - Michigan Tech (2)
- Digital Commons - Montana Tech (1)
- Digital Commons @ DU | University of Denver Research (1)
- Digital Commons at Florida International University (4)
- Digital Peer Publishing (2)
- Digital Repository at Iowa State University (4)
- DigitalCommons@The Texas Medical Center (10)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (9)
- Doria (National Library of Finland DSpace Services) - National Library of Finland, Finland (10)
- DRUM (Digital Repository at the University of Maryland) (2)
- Duke University (3)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (12)
- Harvard University (17)
- Helvia: Repositorio Institucional de la Universidad de Córdoba (1)
- Instituto Politécnico de Leiria (1)
- Instituto Politécnico do Porto, Portugal (12)
- Massachusetts Institute of Technology (1)
- National Center for Biotechnology Information - NCBI (27)
- Nottingham eTheses (1)
- Publishing Network for Geoscientific & Environmental Data (18)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (1)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- ReCiL - Repositório Científico Lusófona - Grupo Lusófona, Portugal (1)
- Repositório Alice (Acesso Livre à Informação Científica da Embrapa / Repository Open Access to Scientific Information from Embrapa) (1)
- Repositório Científico da Universidade de Évora - Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (5)
- Repositório da Escola Nacional de Administração Pública (ENAP) (1)
- Repositório da Produção Científica e Intelectual da Unicamp (2)
- Repositorio de la Universidad de Cuenca (1)
- Repositório digital da Fundação Getúlio Vargas - FGV (6)
- REPOSITORIO DIGITAL IMARPE - INSTITUTO DEL MAR DEL PERÚ, Peru (1)
- Repositório Institucional da Universidade de Brasília (2)
- Repositório Institucional da Universidade Federal do Rio Grande do Norte (3)
- Repositório Institucional da Universidade Tecnológica Federal do Paraná (RIUT) (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (140)
- RUN (Repositório da Universidade Nova de Lisboa) - FCT (Faculdade de Cienecias e Technologia), Universidade Nova de Lisboa (UNL), Portugal (8)
- Savoirs UdeS : plateforme de diffusion de la production intellectuelle de l’Université de Sherbrooke - Canada (1)
- Scielo Saúde Pública - SP (17)
- Universidad de Alicante (1)
- Universidad del Rosario, Colombia (5)
- Universidad Politécnica de Madrid (19)
- Universidade Complutense de Madrid (3)
- Universidade do Minho (2)
- Universidade Federal do Pará (3)
- Universidade Federal do Rio Grande do Norte (UFRN) (26)
- Universidade Metodista de São Paulo (5)
- Universidade Técnica de Lisboa (1)
- Universitätsbibliothek Kassel, Universität Kassel, Germany (2)
- Université de Lausanne, Switzerland (38)
- Université de Montréal (1)
- Université de Montréal, Canada (21)
- University of Michigan (102)
- University of Queensland eSpace - Australia (17)
- University of Washington (1)
- WestminsterResearch - UK (1)
Resumo:
Work conducted in the Millard Biochemistry Research Laboratory examines the dual nature of molecules as carcinogens and anti-tumor agents through the molecular mechanisms of duplex DNA damage by bifunctional alkylating agents. Diepoxybutane (DEB) and epichlorohydrin (ECH) are polar molecules that form covalent DNA interstrand lesions by cross-linking the N7 position of deoxyguanosine residues. A recent experiment indicated that ECH preferentially targets nuclear DNA over mitochondrial DNA, whereas DEB shows similar rates of lesion formation for both loci. It was concluded that preferential targeting of nuclear DNA results from relatively poor uptake of ECH across the mitochondrial membrane. The objective of my honors research was to determine if the cytotoxicities of DEB and ECH vary according to the presence of the nuclear envelope in 6C2 chicken erythro-progenitor cells. The cytotoxicity of DEB and ECH was compared between cells randomly distributed throughout the cell cycle (Go/G, and S » G2/M) and cells enriched in G2/M stages. Results indicated that ECH is more cytotoxic than DEB in both unsynchronized control 6C2 cells and synchronized 6C2 cells enriched in G2/M stages of the cell cycle. Treatment with either bifunctional alkylating agent induced greater cytotoxicity in 6C2 cells enriched in G2/M stages than in unsynchronized control 6C2 cells, suggesting that the presence of the nuclear envelope-or any plasma membrane-may inhibit the reactivity of DEB and ECH.