Pressure Perturbation Calorimetry and Guest-Host Chemistry of NDMG and N-MAP with p-Sulfonatocalix[6]arene

The aim of this project is to provide an explanation for recently obtained binding constants for two similar guest molecules, NDMG and N-MAP, with a p-sulfonatocalix[6]arene host in ammonium acetate buffer. This work was done primarily using pressure perturbation calorimetry, which is a technique that determines the coefficient of thermal expansion, α, which is in turn related to the solute molecule's effect on the order of the surrounding water molecules. A series of experiments were designed to test the effects of suspected confounding variables on the validity of PPC data. PPC was then used to study NDMG and N-MAP in ammonium acetate buffer. NDMG exhibited a minimum in α as function of temperature, while N-MAP did not. This difference was theorized to be due to the formation of an intramolecular hydrogen bond in monocationic NDMG that would lower the heat capacity of the molecule and better distribute the molecule's charge. Computational work and nuclear magnetic resonance spectroscopy confirmed that monocationic, ring-closed NDMG has less concentrated charge and more constrained motion than monocationic, ring-open NDMG. This evidence supports the theory that monocationic NDMG forms an intramolecular hydrogen bond and that this may be responsible for the minimum in α. This difference may explain the differences in binding constants between NDMG and N-MAP.

Synoptic problem : an investigation of synoptic relationships

In recent years, the Synoptic Problem has become an important focus of New Testament scholarship. The Two-Document Hypothesis, although still widely accepted as the solution, has recently been challenged by a variety of source hypotheses, most notably the Griesbach hypothesis. In effect, the Synoptic Problem has become an open question for an increasing number of scholars. This project analyzes four significant pericopae, the Empty Tomb Tradition, the Kingdom Parables Discourse, the Synoptic Apocalypse, and the Transfiguration Narrative, in an attempt to determine priority and dependence among the synoptic Gospels. The study does not presuppose a particular source theory, although it does evaluate specific ones when applicable. The aim of the study is to conduct an analysis of a limited but representative amount of synoptic material in order to develop a working hypothesis concerning synoptic relationships.