Frequency distribution of TATA box and extension sequences on human promoters

TATA box is one of the most important transcription factor binding sites. But the exact sequences of TATA box are still not very clear yet. In this study, we conducted a dedicated analysis on the frequency distribution of TATA Box and its extension sequences on human promoters. Sixteen TATA elements derived from TATA Box motif, TATAWAWN, were classified into three distribution patterns: peak, bottom-peak and bottom. Fourteen TATA extension sequences (up to two base extensions) were predicted to be the new TATA Box elements because of their high motif factors, which indicate their statistical significance. Statistical analysis on the promoters of mouse, zebrafish and drosophila melanogaster verified seven of these elements. It was also observed that the distribution of TATA elements on the promoters of housekeeping genes are very similar with their distribution on the promoters of tissue specific genes in human.

Applying external solutions to organizational development : elearning as a platform for internal growth

Innovations in technology have facilitated eLearning process development, bringing significant impact into education. eLearning is not simply putting study materials online on the Web, nor is it a substitute for traditional classroom teaching (KPMG, 2002). Businesses worldwide have been using eLearning as a facilitator in organisational development through knowledge sharing, especially in the area of web based training and project management. eLearning has also become a large area of potential business for many organisations. In this study, we explore how eLearning has helped an organisation based in India – Tata Interactive Systems (part of TATA conglomerate), which provides eLearning solutions for businesses locally and globally. In this single case study, we explored how the organisation has not only utilised eLearning as an internal development process, but also successfully converted this learning into business opportunities for itself. To study the development process, we have applied the process theories of Van De Ven and Poole (1995).

A computational framework for nucleic acid sub-sequence identification

Identification of nucleic acid sub-sequences within larger background sequences is a fundamental need of the biology community. The applicability correlates to research studies looking for homologous regions, diagnostic purposes and many other related activities. This paper serves to detail the approaches taken leading to sub-sequence identification through the use of hidden Markov models and associated scoring optimisations. The investigation of techniques for locating conserved basal promoter elements correlates to promoter thus gene identification techniques. The case study centred on the TATA box basal promoter element, as such the background is a gene sequence with the TATA box the target. Outcomes from the research conducted, highlights generic algorithms for sub-sequence identification, as such these generic processes can be transposed to any case study where identification of a target sequence is required. Paths extending from the work conducted in this investigation have led to the development of a generic framework for the future applicability of hidden Markov models to biological sequence analysis in a computational context.

World's smallest business community : the parsis of India

The Parsis of India are perhaps the world’s smallest ethnic community whose entrepreneurial contribution to India has far exceeded their size in numbers. This paper traces the rise of the Parsis as entrepreneurs in Indian society from the 16th century in Surat and later Mumbai to their significant presence today amongst India’s major business houses with household names such as the Tatas, Wadias and Godrej.

Introduction

For a long time we held the view that if you had a particular skill – such as accountancy, trades, engineering, IT, management – all you needed to make a success of life was to learn some “soft skills”. These soft skills included communication, presenting and speaking, team building and so on.
Yet the continuing problem with this approach has been that despite lots of training, many people never actually improved their ability to communicate, get on with others, make good speeches or build teams.
Public relations professionals around the world must find the “flat world” message very encouraging. This message is telling corporations that in a flat world, the biggest differentiator is your people. How do people effectively differentiate? We differentiate ourselves by becoming better communicators. PR campaign skills can come to the forefront as organisations seek to thrive in this new world using a strategic planning approach.