Focusing in on structural genomics : the University of Queensland structural biology pipeline

The flood of new genomic sequence information together with technological innovations in protein structure determination have led to worldwide structural genomics (SG) initiatives. The goals of SG initiatives are to accelerate the process of protein structure determination, to fill in protein fold space and to provide information about the function of uncharacterized proteins. In the long-term, these outcomes are likely to impact on medical biotechnology and drug discovery, leading to a better understanding of disease as well as the development of new therapeutics. Here we describe the high throughput pipeline established at the University of Queensland in Australia. In this focused pipeline, the targets for structure determination are proteins that are expressed in mouse macrophage cells and that are inferred to have a role in innate immunity. The aim is to characterize the molecular structure and the biochemical and cellular function of these targets by using a parallel processing pipeline. The pipeline is designed to work with tens to hundreds of target gene products and comprises target selection, cloning, expression, purification, crystallization and structure determination. The structures from this pipeline will provide insights into the function of previously uncharacterized macrophage proteins and could lead to the validation of new drug targets for chronic obstructive pulmonary disease and arthritis.

Submarine sonar FX

Submarine Sonar FX is a sound effect of a submarine/nautical type of sonar.

An overview of methods for simulating and evaluating pipeline corrosion

Steel pipelines, buried under the soil and protected by the combination of protective coatings and cathodic protection (CP), are used for oil and gas transportation. These pipelines are one of the critical infrastructures for energy transportation and therefore became lifelines of modern society. The deterioration of the external surfaces of transmission pipelines is a serious problem and is caused mainly by coating and/or CP failure leading to the loss of integrity of pipelines. To avoid such damage, there is a need of techniques which are able to locate active corrosion sites, monitor corrosion, and evaluate corrosion damage. Fundamental understanding of such processes occurring on coated pipelines (with various types of defects in coatings as well as pipe) in complex soil environment is necessary for the development of such techniques. Numerous laboratory techniques, i.e., electrochemical impedance spectroscopy based, polarisation measurements based, mathematical simulations, direct observation etc. have been used to develop fundamental understanding, simulate and evaluate corrosion occurring in oil and gas pipelines under various operating conditions. Given the complex nature of the pipeline corrosion, application of these laboratory techniques in field measurements as well as in understanding the corrosion mechanisms is lacking. This paper presents an overview of investigations, based on electrochemical techniques, for simulation and evaluation of pipeline corrosion in laboratory.

Analysis of lightning current characteristics to investigate lightning strike damages to energy pipeline

Australia is one of the most lightning prone area on earth. Lightning strikes have been identified as one of the most common cause of energy pipeline damage in Australia. Therefore, a suitable protection schemes and mitigation strategies against lighting strike damage is very important for Australian pipeline industry. There are a number of research on lighting protection of establishment such as, power systems, buildings, and telecommunications systems, however, very few publications could be found which discuss about protection of pipeline from lightning strike. Assessment of effects in buried pipeline, due to lighting strikes is important. Existing models do not account adequately the effect of the characteristics of soil breakdown channels intercepted by the buried object. This paper aims to investigate the characteristics of lightning current on metal object under the soil of strike point so that lighting attachment to energy pipeline could be understand and a protection technique could be developed. Along with lightning current characteristics, lightning attachment process, distribution method, soil resistivity, propagation of lightning current in soil with a buried pipeline, pipeline electrical properties and other related areas and technologies is explored. The study shows that though there are some research on characteristics of induced on simple buried structures like narrow telephone cable or residential gas pipe, but no substantial research have been done on large comparatively complex structures like buried energy pipelines. Also dynamic behavior of soil and the object to be protected not been considered in protections schemes and experiments.

A novel approach for monitoring pipeline corrosion under disbonded coatings

Underground pipeline corrosion monitoring is a complex technical challenge. Currently there is no corrosion monitoring probe that is able to provide in situ information on corrosion under disbonded coatings. This paper presents a proof of concept of a novel corrosion monitoring probe intended to simulate corrosion under disbonded pipeline coatings and monitor its rate under Cathodic Protection (CP). The probe's capabilities to measure corrosion rates and simulate disbonded coating conditions are illustrated by a typical experiment that involved testing of the probe in 0.1M NaCl at -850mVCSE. Estimated metal thickness losses based on results measured by the probe were compared against corrosion patterns and profilometry measurements of control specimens exposed to the same conditions.

An overview of new progresses in understanding pipeline corrosion

An approach to achieving the ambitious goal of cost effectively extending the safe operation life of energy pipeline to 100 years is the application of health monitoring and life prediction tools that are able to provide both long-term remnant pipeline life prediction and in-situ pipeline condition monitoring. A critical step is the enhancement of technological capabilities that are required for understanding and quantifying the effects of key factors influencing buried steel pipeline corrosion and environmentally assisted materials degradation, and the development of condition monitoring technologies that are able to provide in-situ monitoring and site-specific warning of pipeline damage. This paper provides an overview of our current research aimed at developing new sensors and electrochemical cells for monitoring, categorising and quantifying the level and nature of external pipeline and coating damages under the combined effects of various inter-related variables and processes such as localised corrosion, coating cracking and disbondment, cathodic shielding, transit loss of cathodic protection.

The importance of outreach programs to unblock the pipeline and broaden diversity in ICT education

There is a need for outreach programs to attract a diverse range of students to the computing discipline. The lack of qualified computing graduates to fill the growing number of computing vacancies is of concern to government and industry and there are few female students entering the computing pipeline at high school level. This paper presents three outreach programs that have the underlying assumption that students need to be reminded about the creativity and potential of computing so that it remains on the radar of their future career options. Each program instigated social and cultural change through a paradigm shift where girls moved from being ICT consumers to ICT creators. By exposing students to a wide variety of ICT activities and careers during secondary schooling, they were more likely to consider studying information systems, computer science or any other computing course at the university level. Results are presented showing student attitudinal changes as well as observed increases in enrolments at secondary school and university courses