Medical diagnosis by fuzzy standard additive model with wavelets

This paper proposes a combination of fuzzy standard additive model (SAM) with wavelet features for medical diagnosis. Wavelet transformation is used to reduce the dimension of high-dimensional datasets. This helps to improve the convergence speed of supervised learning process of the fuzzy SAM, which has a heavy computational burden in high-dimensional data. Fuzzy SAM becomes highly capable when deployed with wavelet features. This combination remarkably reduces its computational training burden. The performance of the proposed methodology is examined for two frequently used medical datasets: the lump breast cancer and heart disease. Experiments are deployed with a five-fold cross validation. Results demonstrate the superiority of the proposed method compared to other machine learning methods including probabilistic neural network, support vector machine, fuzzy ARTMAP, and adaptive neuro-fuzzy inference system. Faster convergence but higher accuracy shows a win-win solution of the proposed approach.

Community attitudes towards the early detection of cancer in Victoria, Australia

Objectives: To describe people's attitudes towards early detection of cancer.

Methods: We conducted a telephone survey of Victorian adults aged 18+ years, during April-May 2005, using a market research company.

Results: 1,502 (41%) people participated; 80% of respondents believed that detecting cancer early meant that treatment saved lives most of the time or always; 88% believed finding cancer early enabled more effective treatment most of the time or always; and 70% indicated they would want to be tested for a cancer even if no treatment were available.  Two-thirds or more of adults considered survival would be very much improved by early detection for breast, melanoma and prostate cancers; 49% for bowel cancer, and 30% for lung cancer.

Conclusions and Implications : Community support for the early detection of cancer was evident even in the absence of effective treatment.  There was a lower perceived survival benefit for the early diagnosis of bowel cancer or melanoma.  An education campaign is required that focuses on the gains associated with early detection and benefits of screening for bowel cancer.

Agent-based hybrid framework for decision making on complex problems

Electronic commerce and the Internet have created demand for automated systems that can make complex decisions utilizing information from multiple sources. Because the information is uncertain, dynamic, distributed, and heterogeneous in nature, these systems require a great diversity of intelligent techniques including expert systems, fuzzy logic, neural networks, and genetic algorithms. However, in complex decision making, many different components or sub-tasks are involved, each of which requires different types of processing. Thus multiple such techniques are required resulting in systems called hybrid intelligent systems. That is, hybrid solutions are crucial for complex problem solving and decision making. There is a growing demand for these systems in many areas including financial investment planning, engineering design, medical diagnosis, and cognitive simulation. However, the design and development of these systems is difficult because they have a large number of parts or components that have many interactions. From a multi-agent perspective, agents in multi-agent systems (MAS) are autonomous and can engage in flexible, high-level interactions. MASs are good at complex, dynamic interactions. Thus a multi-agent perspective is suitable for modeling, design, and construction of hybrid intelligent systems. The aim of this thesis is to develop an agent-based framework for constructing hybrid intelligent systems which are mainly used for complex problem solving and decision making. Existing software development techniques (typically, object-oriented) are inadequate for modeling agent-based hybrid intelligent systems. There is a fundamental mismatch between the concepts used by object-oriented developers and the agent-oriented view. Although there are some agent-oriented methodologies such as the Gaia methodology, there is still no specifically tailored methodology available for analyzing and designing agent-based hybrid intelligent systems. To this end, a methodology is proposed, which is specifically tailored to the analysis and design of agent-based hybrid intelligent systems. The methodology consists of six models - role model, interaction model, agent model, skill model, knowledge model, and organizational model. This methodology differs from other agent-oriented methodologies in its skill and knowledge models. As good decisions and problem solutions are mainly based on adequate information, rich knowledge, and appropriate skills to use knowledge and information, these two models are of paramount importance in modeling complex problem solving and decision making. Follow the methodology, an agent-based framework for hybrid intelligent system construction used in complex problem solving and decision making was developed. The framework has several crucial characteristics that differentiate this research from others. Four important issues relating to the framework are also investigated. These cover the building of an ontology for financial investment, matchmaking in middle agents, reasoning in problem solving and decision making, and decision aggregation in MASs. The thesis demonstrates how to build a domain-specific ontology and how to access it in a MAS by building a financial ontology. It is argued that the practical performance of service provider agents has a significant impact on the matchmaking outcomes of middle agents. It is proposed to consider service provider agents' track records in matchmaking. A way to provide initial values for the track records of service provider agents is also suggested. The concept of ‘reasoning with multimedia information’ is introduced, and reasoning with still image information using symbolic projection theory is proposed. How to choose suitable aggregation operations is demonstrated through financial investment application and three approaches are proposed - the stationary agent approach, the token-passing approach, and the mobile agent approach to implementing decision aggregation in MASs. Based on the framework, a prototype was built and applied to financial investment planning. This prototype consists of one serving agent, one interface agent, one decision aggregation agent, one planning agent, four decision making agents, and five service provider agents. Experiments were conducted on the prototype. The experimental results show the framework is flexible, robust, and fully workable. All agents derived from the methodology exhibit their behaviors correctly as specified.

Organizational factors associated with decreased mortality among veterans affairs patients with an ICU stay

In-hospital mortality rates associated with an ICU stay are high and vary widely among units. This variation may be related to organizational factors such as staffing patterns, ICU structure, and care processes. We aimed to identify organizational factors associated with variation in in-hospital mortality for patients with an ICU stay. This was a retrospective observational cross-sectional study using administrative data from 34 093 patients from 171 ICUs in 119 Veterans Health Administration hospitals. Staffing and patient data came from Veterans Health Administration national databases. ICU characteristics came from a survey in 2004 of ICUs within the Veterans Health Administration. We conducted multilevel multivariable estimation with patient-, unit-, and hospital-level data. The primary outcome was in-hospital mortality. Of 34 093 patients, 2141 (6.3%)died in the hospital. At the patient level, risk of complications and having a medical diagnosis were significantly associated with a higher risk of mortality. At the unit level, having an interface with the electronic medical record was significantly associated with a lower risk of mortality. The finding that electronic medical records integrated with ICU information systems are associated with lower in-hospital mortality adds support to existing evidence on organizational characteristics associated with in-hospital mortality among ICU patients.

A modified fuzzy min-max neural network with a genetic-algorithm-based rule extractor for pattern classification

In this paper, a two-stage pattern classification and rule extraction system is proposed. The first stage consists of a modified fuzzy min-max (FMM) neural-network-based pattern classifier, while the second stage consists of a genetic-algorithm (GA)-based rule extractor. Fuzzy if-then rules are extracted from the modified FMM classifier, and a ??don't care?? approach is adopted by the GA rule extractor to minimize the number of features in the extracted rules. Five benchmark problems and a real medical diagnosis task are used to empirically evaluate the effectiveness of the proposed FMM-GA system. The results are analyzed and compared with other published results. In addition, the bootstrap hypothesis analysis is conducted to quantify the results of the medical diagnosis task statistically. The outcomes reveal the efficacy of FMM-GA in extracting a set of compact and yet easily comprehensible rules while maintaining a high classification performance for tackling pattern classification tasks.

Fuzzy ARTMAP and hybrid evolutionary programming for pattern classification

In this paper, an Evolutionary Artificial Neural Network (EANN) that combines the Fuzzy ARTMAP (FAM) network and a Hybrid Evolutionary Programming (HEP) model is introduced. The proposed FAM-HEP model, which combines the strengths of FAM and HEP, is able to construct its network structure autonomously as well as to perform learning and evolutionary search and adaptation concurrently. The effectiveness of the proposed FAM-HEP network is assessed empirically using several benchmark data sets and a real medical diagnosis problem. The performance of FAM-HEP is analyzed, and the results are compared with those of FAM-EP, FAM, and other classification models. In general, the results of FAM-HEP are better than those of FAM-EP and FAM, and are comparable with those from other classification models. The study also reveals the potential of FAM-HEP as an innovative EANN model for undertaking pattern classification problems in general, and a promising computerized decision support tool for tackling medical diagnosis tasks in particular.

An experimental study of original and ordered fuzzy ARTMAP neural networks in pattern classification tasks

This paper investigates the effectiveness of an ordering algorithm applied to the supervised Fuzzy ARTMAP (FAM) neural network in pattern classification tasks. Before presenting the input patterns to the FAM network (known as ordered FAM), a fixed order of input patterns is first identified using the ordering algorithm. An experimental study is conducted to compare the results from ordered FAM with the average and voting results from original FAM. In the study, a pool of the original FAM networks is trained using different sequences of input patterns, and the results are averaged. Outputs from various original FAM networks can also be combined using a majority voting strategy to reach a final result. A database comprising various symptoms and measurements of patients suffering from heart attack is used to evaluate the various schemes of the FAM network in medical pattern classification tasks. The results are compared, analyzed, and discussed.

Potentials of social media for tacit knowledge sharing amongst physicians : preliminary findings

Tacit knowledge sharing amongst physicians, such as the sharing of clinical experiences, skills, or know-how, or know-whom, is known to have a significant impact on the quality of medical diagnosis and decisions. This paper posits that social media can provide new opportunities for tacit knowledge sharing amongst physicians, and demonstrates this by presenting findings from a review of relevant literature and a survey conducted with physicians. Semi-structured interviews were conducted with ten physicians from around the world who were active users of social media. Initial thematic analysis revealed eight themes as potential contributions of social web tools to facilitate tacit knowledge flow amongst physicians. The emergent themes are defined, linked to the literature, and supported by instances of interview transcripts. Findings presented here are preliminary, and final results will be reported after accomplishing all phases of data collection and analysis.

Boosting the performance of the fuzzy min-max neural network in pattern classification tasks

In this paper, a boosted Fuzzy Min-Max Neural Network (FMM) is proposed. While FMM is a learning algorithm which is able to learn new classes and to refine existing classes incrementally, boosting is a general method for improving accuracy of any learning algorithm. In this work, AdaBoost is applied to improve the performance of FMM when its classification results deteriorate from a perfect score. Two benchmark databases are used to assess the applicability of boosted FMM, and the results are compared with those from other approaches. In addition, a medical diagnosis task is employed to assess the effectiveness of boosted FMM in a real application. All the experimental results consistently demonstrate that the performance of FMM can be considerably improved when boosting is deployed.

An enhanced fuzzy min-max neural network for pattern classification

An enhanced fuzzy min-max (EFMM) network is proposed for pattern classification in this paper. The aim is to overcome a number of limitations of the original fuzzy min-max (FMM) network and improve its classification performance. The key contributions are three heuristic rules to enhance the learning algorithm of FMM. First, a new hyperbox expansion rule to eliminate the overlapping problem during the hyperbox expansion process is suggested. Second, the existing hyperbox overlap test rule is extended to discover other possible overlapping cases. Third, a new hyperbox contraction rule to resolve possible overlapping cases is provided. Efficacy of EFMM is evaluated using benchmark data sets and a real medical diagnosis task. The results are better than those from various FMM-based models, support vector machine-based, Bayesian-based, decision tree-based, fuzzy-based, and neural-based classifiers. The empirical findings show that the newly introduced rules are able to realize EFMM as a useful model for undertaking pattern classification problems.

Mobile health (mHealth) biomedical imaging paradigm

Technology assisted methods for medical diagnosis and biomedical health monitoring are rapidly shifting from classical invasive methods to handheld-based non-invasive approaches. Biomedical imagining is one of the most prominent practices of non-invasive mechanisms in medical applications. This paper considers the medical imaging schemes for Mobile Health (mHealth) applications and studies the feasibility of future mobile systems for accommodating image informatics capabilities.