Design of a high sensitive double-gate field-effect transistor biosensor for DNA detection

The study of interactions between organic biomolecules and semiconducting surfaces is an important consideration for the design and fabrication of field-effect-transistor (FET) biosensor. This paper demonstrates DNA detection by employing a double-gate field effect transistor (DGFET). In addition, an investigation of sensitivity and signal to noise ratio (SNR) is carried out for different values of analyte concentration, buffer ion concentration, pH, reaction constant, etc. Sensitivity, which is indicated by the change of drain current, increases non-linearly after a specific value (∼1nM) of analyte concentration and decreases non-linearly with buffer ion concentration. However, sensitivity is linearly related to the fluidic gate voltage. The drain current has a significant effect on the positive surface group (-NH2) compared to the negative counterpart (-OH). Furthermore, the sensor has the same response at a particular value of pH (5.76) irrespective of the density of surface group, although it decreases with pH value. The signal to noise ratio is improved with higher analyte concentrations and receptor densities.

Fuzzy logic for decision support in chronic care

Computerized clinical guidelines can provide significant benefits in terms of health outcomes and costs, however, their effective computer implementation presents significant problems. Vagueness and ambiguity inherent in natural language (textual) clinical guidelines makes them problematic for formulating automated alerts or advice. Fuzzy logic allows us to formalize the treatment of vagueness in a decision support architecture. In care plan on-line (CPOL), an intranet-based chronic disease care planning system for general practitioners (GPs) in use in South Australia, we formally treat fuzziness in interpretation of quantitative data, formulation of recommendations and unequal importance of clinical indicators. We use expert judgment on cases, as well as direct estimates by experts, to optimize aggregation operators and treat heterogeneous combinations of conjunction and disjunction that are present in the natural language decision rules formulated by specialist teams.

Macleod and the offence of defrauding the company in one-person businesses: the divergence between legal principle and logic widens

The recent High Court decision in Macleod v R establishes that a director and sole shareholder may be convicted of fraudulently applying a company's property even though the person has consented to the personal use of the company's property. It is contended that while this decision is consistent with the weight of precedent, it is wrong in principle. The decision implies that corporations are not only separate legal entities, but that they are highly virtuous legal entities -- incapable of being imbued with the dishonest intentions and activities of the individuals controlling the company.

The Fiftieth Gate : an Australian case study in twentieth-century 'popular' publishing

On Sunday 6 April 1997, historian Mark Baker's first non-academic book was launched at Melbourne's iconic migrant portal, Station Pier. The guest list of over 500 invitees included representatives of many print media organisations, most of whom interviewed the author. His photograph was reproduced a week later in the 'Agenda' section of The Age newspaper. In this portrait, Baker leans on the railings beside the massive structure of Station Pier. Framed by sea and sky, he is caught glancing pensively over his shoulder past the camera and into the middle distance. He is alone. The day is bleak. Here, the reader is invited to surmise, is a man with much on his mind. In a flash of inspiration the sub-editor has prefaced the accompanying caption, 'Back to the future', linking the story with the mass media of film and television.

Fuzzy logic based metric in software testing

How to provide cost-effective strategies for Software Testing has been one of the research focuses in Software Engineering for a long time. Many researchers in Software Engineering have addressed the effectiveness and quality metric of Software Testing, and many interesting results have been obtained. However, one issue of paramount importance in software testing – the intrinsic imprecise and uncertain relationships within testing metrics – is left unaddressed. To this end, a new quality and effectiveness measurement based on fuzzy logic is proposed. The software quality features and analogy-based reasoning are discussed, which can deal with quality and effectiveness consistency between different test projects. Experimental results are also provided to verify the proposed measurement.

A fuzzy logic based approach for software testing

How to provide cost-effective strategies for Software Testing has been one of the research focuses in Software Engineering for a long time. Many researchers in Software Engineering have addressed the effectiveness and quality metric of Software Testing, and many interesting results have been obtained. However, one issue of paramount importance in software testing — the intrinsic imprecise and uncertain relationships within testing metrics — is left unaddressed. To this end, a new quality and effectiveness measurement based on fuzzy logic is proposed. Related issues like the software quality features and fuzzy reasoning for test project similarity measurement are discussed, which can deal with quality and effectiveness consistency between different test projects. Experiments were conducted to verify the proposed measurement using real data from actual software testing projects. Experimental results show that the proposed fuzzy logic based metrics is effective and efficient to measure and evaluate the quality and effectiveness of test projects.

Minimization of reversible adder circuits

Losing information causes losing power. Information is lost when the input vector cannot be uniquely recovered from the output vector of a combinational circuit. The input vector of reversible circuit can be uniquely recovered from the output vector. In this study we have emphasized on the design of reversible adder circuits that is efficient in terms of gate count, garbage outputs and quantum cost and that can be technologically mapped. It has been analyzed and demonstrated that the results of our proposed adder circuits shows better performance compared to similar type of existing designs. Technology independent equations required to evaluate these circuits have also been given.

Logic games

Discusses innovations on logic games which will develop the problem solving and spatial thinking of students. Variations of existing logic games; Description of the innovated games; Advice on introducing logic games to students.

Fuzzy logic in clinical practice decision support systems

Computerized clinical guidelines can provide significant benefits to health outcomes and costs, however, their effective implementation presents significant problems. Vagueness and ambiguity inherent in natural (textual) clinical guidelines is not readily amenable to formulating automated alerts or advice. Fuzzy logic allows us to formalize the treatment of vagueness in a decision support architecture. This paper discusses sources of fuzziness in clinical practice guidelines. We consider how fuzzy logic can be applied and give a set of heuristics for the clinical guideline knowledge engineer for addressing uncertainty in practice guidelines. We describe the specific applicability of fuzzy logic to the decision support behavior of Care Plan On-Line, an intranet-based chronic care planning system for General Practitioners.