Bis(3-endo-camphoryl)phosphinic acid, a non-racemic helical supramolecular host with aquapores

Bis(3-endo-camphoryl)phosphinic acid (1) was prepared by the reaction of the lithium enolate of D-(+)-camphor and phosphorous trichloride followed by an oxidative work up. Compound 1 crystallizes from wet toluene as monohydrate 1·H2O, which was investigated by X-ray crystallography. Molecules of 1 are associated by strong hydrogen bonds giving rise to the formation of a supramolecular helix. The interior channel of the helix is filled by a one-dimensional (1D) string of water molecules that are also associated by hydrogen bonding. The 1D string adopts a twisted zigzag conformation. Although the hydrogen bond networks are not cross-linked both the screw of the helix and the twist of the 1D string of water molecules are left-handed (M) and controlled by the chiral camphoryl residues situated on the exterior of the helix. The overall supramolecular structure is strongly reminiscent of aquaporin-1, a significant membrane-channel protein responsible for the transport of water into the cells.

Performance of smart antennas with receive diversity in wireless sensor networks

In this paper we propose a Geometrically Based Single Bounce Elliptical Model (GBSBEM) for multipath components involving randomly placed scatterers in the scattering region with sensors deployed on a field. The system model assumes a cluster based wireless sensor network (WSN) which collects information from the sensors, filters and modulates the data and transmit it through a wireless channel to be collected at the receiver. We first develop a GBSBE model and based on this model we develop our channel model. Use of Smart antenna system at the receiver end, which exploits various receive diversity combining techniques like Maximal Ratio Combining (MRC), Equal Gain Combining (EGC), and Selection Combining (SC), adds novelty to this system. The performance of these techniques have been proved through matlab simulations and further ahead based on different number of antenna elements present at the receiver array, we calculate the performance of our system in terms of bit-error-rate (BER). Based on the transmission power we quantify for the energy efficiency of our communication model.

Multi-input-multi-output antennas for radio frequency identification systems

In this chapter the authors discuss the physical insight of the role of wireless communication in RFID systems. In this respect, this chapter gives a brief introduction on the wireless communication model followed by various communication schemes. The chapter also discusses various channel impairments and the statistical modeling of fading channels based on the environment in which the RFID tag and reader may be present. The chapter deals with the fact that the signal attenuations can be dealt with up to some level by using multiple antennas at the reader transmitter and receiver to improve the performance. Thus, this chapter discusses the use of transmit diversity at the reader transmitter to transmit multiple copies of the signal. Following the above, the use of receiver combining techniques are discussed, which shows how the multiple copies of the signal arriving at the reader receiver from the tag are combined to reduce the effects of fading. The chapter then discusses various modulation techniques required to modulate the signal before transmitting over the channel. It then presents a few channel estimation algorithms, according to which, by estimating the channel state information of the channel paths through which transmission takes place, performance of the wireless system can be further increased. Finally, the Antenna selection techniques are presented, which further helps in improving the system performance.

Lactam-stabilized helical analogues of the analgesic μ-Conotoxin KIIIA

μ-Conotoxin KIIIA (μ-KIIIA) blocks mammalian voltage-gated sodium channels (VGSCs) and is a potent analgesic following systemic administration in mice. Previous structure–activity studies of μ-KIIIA identified a helical pharmacophore for VGSC blockade. This suggested a route for designing truncated analogues of μ-KIIIA by incorporating the key residues into an α-helical scaffold. As (i, i+4) lactam bridges constitute a proven approach for stabilizing α-helices, we designed and synthesized six truncated analogues of μ-KIIIA containing single lactam bridges at various locations. The helicity of these lactam analogues was analyzed by NMR spectroscopy, and their activities were tested against mammalian VGSC subtypes NaV1.1 through 1.7. Two of the analogues, Ac-cyclo9/13[Asp9,Lys13]KIIIA7–14 and Ac-cyclo9/13[Lys9,Asp13]KIIIA7–14, displayed μM activity against VGSC subtypes NaV1.2 and NaV1.6; importantly, the subtype selectivity profile for these peptides matched that of μ-KIIIA. Our study highlights structure–activity relationships within these helical mimetics and provides a basis for the design of additional truncated peptides as potential analgesics.

A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily

Cone snail venoms are a rich source of peptides, many of which are potent and selective modulators of ion channels and receptors. Here we report the isolation and characterization of two novel conotoxins from the venom of Conus imperialis. These two toxins contain a novel cysteine framework, C-C-C-CC-C, which has not been found in other conotoxins described to date. We name it framework XXIII and designate the two toxins im23a and im23b; cDNAs of these toxins exhibit a novel signal peptide sequence, which defines a new K-superfamily. The disulfide connectivity of im23a has been mapped by chemical mapping of partially reduced intermediates and by NMR structure calculations, both of which establish a I-II, III-IV, V-VI pattern of disulfide bridges. This pattern was also confirmed by synthesis of im23a with orthogonal protection of individual cysteine residues. The solution structure of im23a reveals that im23a adopts a novel helical hairpin fold. A cluster of acidic residues on the surface of the molecule is able to bind calcium. The biological activity of the native and recombinant peptides was tested by injection into mice intracranially and intravenously to assess the effects on the central and peripheral nervous systems, respectively. Intracranial injection of im23a or im23b into mice induced excitatory symptoms; however, the biological target of these new toxins has yet to be identified.

On the multicast lifetime of WANETs with multibeam antennas : Formulation, algorithms, and analysis

We explore the multicast lifetime capacity of energy-limited wireless ad hoc networks using directional multibeam antennas by formulating and solving the corresponding optimization problem. In such networks, each node is equipped with a practical smart antenna array that can be configured to support multiple beams with adjustable orientation and beamwidth. The special case of this optimization problem in networks with single beams have been extensively studied and shown to be NP-hard. In this paper, we provide a globally optimal solution to this problem by developing a general MILP formulation that can apply to various configurable antenna models, many of which are not supported by the existing formulations. In order to study the multicast lifetime capacity of large-scale networks, we also propose an efficient heuristic algorithm with guaranteed theoretical performance. In particular, we provide a sufficient condition to determine if its performance reaches optimum based on the analysis of its approximation ratio. These results are validated by experiments as well. The multicast lifetime capacity is then quantitatively studied by evaluating the proposed exact and heuristic algorithms using simulations. The experimental results also show that using two-beam antennas can exploit most lifetime capacity of the networks for multicast communications. © 2013 IEEE.

Practical asynchronous neighbor discovery in ad hoc networks with directional antennas

Neighbor discovery is a crucial step in the initialization of wireless ad hoc networks. When directional antennas are used, this process becomes more challenging since two neighboring nodes must be in transmit and receive states, respectively, pointing their antennas to each other simultaneously. Most of the proposed neighbor discovery algorithms only consider the synchronous system and cannot work efficiently in the asynchronous environment. However, asynchronous neighbor discovery algorithms are more practical and offer many potential advantages. In this paper, we first analyze a one-way handshake-based asynchronous neighbor discovery algorithm by introducing a mathematical model named 'Problem of Coloring Balls.' Then, we extend it to a hybrid asynchronous algorithm that leads to a 24.4% decrease in the expected time of neighbor discovery. Compared with the synchronous algorithms, the asynchronous algorithms require approximately twice the time to complete the neighbor discovery process. Our proposed hybrid asynchronous algorithm performs better than both the two-way synchronous algorithm and the two-way asynchronous algorithm. We validate the practicality of our proposed asynchronous algorithms by OPNET simulations.