The effects of target length on the visual control of step length for hard and soft impacts

Adjustments to gait were examined when positioning the foot within a narrow target at the end of an approach for two impact conditions, hard and soft. Participants (6 M, 6 F) ran toward a target of three lengths along a 10-m walkway consisting of two marker strips with alternating black and white 0.5-m markings. Five trials were conducted for each target length and impact task, with trials block randomized between the 6 participants of each gender. A 50-Hz digital video camera panned and filmed each trial from an elevated position adjacent to the walkway. Video footage was digitized to deduce the gait characteristics. A linear speed/accuracy tradeoff between target length and approach time was found for both impact tasks (hard, r = 0.99, p < 0.01; soft, r = 0.96, p < 0.05). For the hard-impact task, visual control time increased linearly (r = 0.99, p < 0.05) when whole-body approach velocity decreased. Visual control time was unaffected by whole-body approach velocity in the soft-impact task. A constant tau-margin of 1.08 describes the onset of visual control when approaching a target while running, with the control of braking during visual control described by a tau-dot of –0.85. Further research is needed to examine the control of braking in different targeting tasks.

Quasiclassical trajectory calculations of collisional energy transfer in propane systems: multiple direct-encounter hard-sphere model

Quasiclassical trajectory calculations of collisional energy transfer from highly vibrationally excited propane + rare gas systems are reported. This work extends our hard-sphere model (A. Linhananta and K. F. Lim, Phys. Chem. Chem. Phys., 2000, 2, 1385) to examine the variation of the internal energy during collisions with a rare bath gas. This was accomplished by recording the vibrational and rotational energy of propane after each atom–atom encounter during trajectory simulations of propane + rare gas systems. This provides detailed information of the energy flow during a collision. It was found that collisions with small number of encounters transfer energy efficiently, whereas those with many encounters do not. Detailed analyses reveal that the former collisions arise from trajectories with high initial impact parameter, whereas the latter have small initial impact parameter. The reason behind this is the dependence of collision energy transfer (CET) of large polyatomic molecules on their shape. This is connected to the well-known role of rotational energy transfer (RET) as a gateway for CET.

Learning how to engage students online in hard times

In a context of financial restraint and enterprising university managers, teacher-researchers have reason to be sceptical about the trend towards online teaching and away from learning for its own sake. This article departs from both economic and technological determinism and turns instead to ideas about technology embedded in social and political institutions. Activity theory offers a useful means of analysing such embeddedness. Its Marxian assumptions about human nature specify a non-deterministic approach to technology. Its dynamic model of the subjects, tools, and objects of activity within a context of rules, a community, and a division of labour helps to specify aspects of the authors process of learning how to use electronic conferencing effectively. A full deployment of activity theory would also analyse the activity of students. Here the evidence comes mainly from the activity of researcher-teachers engaging greater activity among students. The numbers of students involved precludes reliable quantitative analysis but qualitative evidence from students does support conclusions about researcher-teachers learning how to make best use of electronic conferencing.

Translocation of the socially complex black-eared miner manorina melanotis: a trial using hard and soft release techniques

We translocated five colonies of the highly social and co-operatively breeding Black-eared Miner Manorina melanotis, an endangered Australian honeyeater. Two colonies were released immediately (hard release) and two colonies were housed in aviaries for up to a week on-site and then supplied with food for a further week following release (soft release). A fifth colony was released using a combination of methods. All four hard and soft released colonies contained dependent fledglings at the time of release. This appears to be the first translocation of a co-operative species where intact colonies containing multiple breeding females, each with a suite of helpers have been translocated successfully. Both hard and soft release treatments appeared equally successful during an initial monitoring period of up to two months. All four colonies maintained social cohesion, and displayed high levels of survival and site fidelity. Both hard release and one soft release colony attempted to breed within 600 m of their release site within eight weeks of release. The other soft release colony bred 12 months later. We believe the inclusion of dependent young in each translocated colony provided a focus for translocated colonies that promoted site faithfulness and colony cohesion. Results of long-term monitoring remain inconclusive and it is recommended that monitoring be repeated during several future breeding events. Given our findings, we recommend that when translocating highly social species every effort is made to translocate the entire group, hard release techniques be applied and stimuli that enhance group cohesion and site faithfulness (the presence of dependent young) be exploited.

Blood-nourishing and hard-softening capsule costs less in the management of osteoarthriticknee pain : A randomized controlled trial

The blood-nourishing and hard-softening (BNHS) capsule is a traditional Chinese formula used in the symptomatic treatment of inflammation and pain. We conducted this randomized controlled trial to compare the efficacy of BNHS with other commonly prescribed drugs. We recruited 120 patients from two teaching hospitals; 30 patients in each hospital were randomly assigned to receive BNHS. In one hospital, the 30 controls were given another traditional Chinese drug; whereas a Western medicine (chondroprotection drug/Viartril-s) was used as the control in the other hospital. Intervention was carried out over a period of 4 weeks. Primary outcome measures included self-reported pain level, and changes in stiffness and functional ability as measured by the Western Ontario McMaster Universities Osteoarthritis (WOMAC) index. Mixed models were used for statistical analysis. Substantial improvements in disease-specific symptoms were observed, after 4 weeks of treatment, in patients taking BNHS capsules. As assessed by the WOMAC index, pain level of the BNHS group decreased by 57% [95% confidence interval (CI) = 50, 63], stiffness by 63% (95% CI = 55, 71) and functional ability increased by 56% (95% CI = 50, 63). No significant differences were found in any of the outcome measures between the BNHS group and either of the comparison groups. No severe adverse effects were reported. However, this study lacked a placebo group; therefore, we conclude that BNHS appears to be as effective as commonly prescribed medicines for the relief of pain and dysfunction in knee osteoarthritis patients, but costs a lot less than other Western and herbal drugs in the study.

Drug-herb interactions: eliminating toxicity with hard drug design.

By searching the literatures, it was found that a total of 32 drugs interacting with herbal medicines in humans. These drugs mainly include anticoagulants (warfarin, aspirin and phenprocoumon), sedatives and antidepressants (midazolam, alprazolam and amitriptyline), oral contraceptives, anti-HIV agents (indinavir, ritonavir and saquinavir), cardiovascular drug (digoxin), immunosuppressants (cyclosporine and tacrolimus) and anticancer drugs (imatinib and irinotecan). Most of them are substrates for cytochrome P450s (CYPs) and/or P-glycoprotein (PgP) and many of which have narrow therapeutic indices. However, several drugs including acetaminophen, carbamazepine, mycophenolic acid, and pravastatin did not interact with herbs. Both pharmacokinetic (e.g. induction of hepatic CYPs and intestinal PgP) and/or pharmacodynamic mechanisms (e.g. synergistic or antagonistic interaction on the same drug target) may be involved in drug-herb interactions, leading of altered drug clearance, response and toxicity. Toxicity arising from drug-herb interactions may be minor, moderate, or even fatal, depending on a number of factors associated with the patients, herbs and drugs. Predicting drug-herb interactions, timely identification of drugs that interact with herbs, and therapeutic drug monitoring may minimize toxic drug-herb interactions. It is likely to predict pharmacokinetic herb-drug interactions by following the pharmacokinetic principles and using proper models that are used for predicting drug-drug interactions. Identification of drugs that interact with herbs can be incorporated into the early stages of drug development. A fourth approach for circumventing toxicity arising from drug-herb interactions is proper design of drugs with minimal potential for herbal interaction. So-called ”hard drugs” that are not metabolized by CYPs and not transported by PgP are believed not to interact with herbs due to their unique pharmacokinetic properties. More studies are needed and new approached are required to minimize toxicity arising from drug-herb interactions.

Hard at work in Melbourne

The article is a 30-line piece about upcoming Bloomsday events in Melbourne, and appears in the “Bloomsday International” section of the Centre’s Bloomsday Magazine for 2002.

Unjustified enrichment : having a friend wearing different hats, who needs enemies?

The decision in the present case is important for enrichment law within the context of the confirmation and application of : (a) the general requirements of an enrichment action; and (b) the quantum rule pertaining to an enrichment claim.

Does hard determinism render the problem of evil even harder?

Hard determinism, in theological dress, holds that there is no human free will since God is the sufficient active cause of everything that happens in creation. It is surprising that, in the ever-growing literature on the problem of evil, very little attention has been paid to theodicies that adopt a hard determinist outlook. It is commonly assumed that without free will the theodical project is a non-starter. I challenge this long-held assumption by, firstly, developing a cumulative-style theodicy from within a hard determinist framework, and secondly, comparing the merits of such a theodicy with two libertarian rivals, specifically, Molinism and open theism. The hard determinist model of divine providence is, I argue, in no worse shape than the principal models developed by libertarians.

Whither morality in a hard determinist world?

What would the world be like if hard determinism were true, that is, if all events were determined in such a way as to render all our decisions and actions unfree? In particular, what would morality be like? Indeed, could there be anything distinctively moral in such a world, or would we be left with a moral nihilism in which nothing of moral significance remains? In this paper I explore the ethical implications of hard determinism, focusing on the consequences that our lack of free will would have for moral responsibility (and thus praise and blame), moral obligation, moral rightness and wrongness, and moral goodness. I argue that the truth of hard determinism would compel us to significantly revise our commonsensical understanding of these moral categories. I add, however, that this change in moral outlook would not have dire practical consequences, for we would retain the attitudes and emotions that are essential to forming good interpersonal relationships and to developing morally. In fact, far from being a threat to human flourishing, hard determinism offers the prospect of a life that is morally deeper and more fulfilling than in a world in which we are free.

The relationship between innovation and entrepreneurship : easy definition, hard policy

The paper argues that innovation is the combination of an inventive process and an entrepreneurial process to create new economic value for defined stakeholders and focuses on the policy implications of this duality. Attention is concentrated on summarising the entrepreneurial process and its importance to innovation policy and avoids any detailed elaboration of the invention process. A very brief overview of the invention process is followed by a moderately detailed summary of Hindle's (2008) model of entrepreneurial process. With an understanding and formal articulation of entrepreneurial process it becomes possible to focus on the key issues that ought to inform the development of innovation policy. These key issues are discussed and the paper concludes where it began by emphasising the need to build innovation policy on the explicit recognition that innovation results from the blending of two processes, invention and entrepreneurship, and that viable innovation policy can never be created unless entrepreneurial process is properly understood and addressed.