27 resultados para generalized criptococcosis

em Deakin Research Online - Australia


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In this paper we generalize Besag's pseudo-likelihood function for spatial statistical models on a region of a lattice. The correspondingly defined maximum generalized pseudo-likelihood estimates (MGPLEs) are natural extensions of Besag's maximum pseudo-likelihood estimate (MPLE). The MGPLEs connect the MPLE and the maximum likelihood estimate. We carry out experimental calculations of the MGPLEs for spatial processes on the lattice. These simulation results clearly show better performances of the MGPLEs than the MPLE, and the performances of differently defined MGPLEs are compared. These are also illustrated by the application to two real data sets.

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This paper discusses identification of parameters of generalized ordered weighted averaging (GOWA) operators from empirical data. Similarly to ordinary OWA operators, GOWA are characterized by a vector of weights, as well as the power to which the arguments are raised. We develop optimization techniques which allow one to fit such operators to the observed data. We also generalize these methods for functional defined GOWA and generalized Choquet integral based aggregation operators.

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One major difficulty frustrating the application of linear causal models is that they are not easily adapted to cope with discrete data. This is unfortunate since most real problems involve both continuous and discrete variables. In this paper, we consider a class of graphical models which allow both continuous and discrete variables, and propose the parameter estimation method and a structure discovery algorithm based on Minimum Message Length and parameter estimation. Experimental results are given to demonstrate the potential for the application of this method.

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Objective: To assess from a health sector perspective the incremental cost-effectiveness of interventions for generalized anxiety disorder (cognitive behavioural therapy [CBT] and serotonin and noradrenaline reuptake inhibitors [SNRIs]) and panic disorder (CBT, selective serotonin reuptake inhibitors [SSRIs] and tricyclic antidepressants [TCAs]).

Method: The health benefit is measured as a reduction in disability-adjusted life years (DALYs), based on effect size calculations from meta-analyses of randomised controlled trials. An assessment on second stage filters ('equity', 'strength of evidence', 'feasibility' and 'acceptability to stakeholders') is also undertaken to incorporate additional factors that impact on resource allocation decisions. Costs and benefits are calculated for a period of one year for the eligible population (prevalent cases of generalized anxiety disorder/panic disorder identified in the National Survey of Mental Health and Wellbeing, extrapolated to the Australian population in the year 2000 for those aged 18 years and older). Simulation modelling techniques are used to present 95% uncertainty intervals (UI) around the incremental cost-effectiveness ratios (ICERs).

Results: Compared to current practice, CBT by a psychologist on a public salary is the most cost-effective intervention for both generalized anxiety disorder (A$6900/DALY saved; 95% UI A$4000 to A$12 000) and panic disorder (A$6800/DALY saved; 95% UI A$2900 to A$15 000). Cognitive behavioural therapy results in a greater total health benefit than the drug interventions for both anxiety disorders, although equity and feasibility concerns for CBT interventions are also greater.

Conclusions: Cognitive behavioural therapy is the most effective and cost-effective intervention for generalized anxiety disorder and panic disorder. However, its implementation would require policy change to enable more widespread access to a sufficient number of trained therapists for the treatment of anxiety disorders.

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In epidemiologic studies, researchers often need to establish a nonlinear exposure-response relation between a continuous risk factor and a health outcome. Furthermore, periodic interviews are often conducted to take repeated measurements from an individual. The authors proposed to use fractional polynomial models to jointly analyze the effects of 2 continuous risk factors on a health outcome. This method was applied to an analysis of the effects of age and cumulative fluoride exposure on forced vital capacity in a longitudinal study of lung function carried out among aluminum workers in Australia (1995-2003). Generalized estimating equations and the quasi-likelihood under the independence model criterion were used. The authors found that the second-degree fractional polynomial models for age and fluoride fitted the data best. The best model for age was robust across different models for fluoride, and the best model for fluoride was also robust. No evidence was found to suggest that the effects of smoking and cumulative fluoride exposure on change in forced vital capacity over time were significant. The trend 1 model, which included the unexposed persons in the analysis of trend in forced vital capacity over tertiles of fluoride exposure, did not fit the data well, and caution should be exercised when this method is used.

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Citation matching is the problem of extracting bibliographic records from citation lists in technical papers, and merging records that represent the same publication. Generally, there are three types of data- sets in citation matching, i.e., sparse, dense and hybrid types. Typical approaches for citation matching are Joint Segmentation (Jnt-Seg) and Joint Segmentation Entity Resolution (Jnt-Seg-ER). Jnt-Seg method is effective at processing sparse type datasets, but often produces many errors when applied to dense type datasets. On the contrary, Jnt-Seg-ER method is good at dealing with dense type datasets, but insufficient when sparse type datasets are presented. In this paper we propose an alternative joint inference approach–Generalized Joint Segmentation (Generalized-Jnt-Seg). It can effectively deal with the situation when the dataset type is unknown. Especially, in hybrid type datasets analysis there is often no a priori information for choosing Jnt-Seg method or Jnt-Seg-ER method to process segmentation and entity resolution. Both methods may produce many errors. Fortunately, our method can effectively avoid error of segmentation and produce well field boundaries. Experimental results on both types of citation datasets show that our method outperforms many alternative approaches for citation matching.

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The performance of the modified adaptive conjugate gradient (CG) algorithms based on the iterative CG method for adaptive filtering is highly related to the ways of estimating the correlation matrix and the cross-correlation vector. The existing approaches of implementing the CG algorithms using the data windows of exponential form or sliding form result in either loss of convergence or increase in misadjustment. This paper presents and analyzes a new approach to the implementation of the CG algorithms for adaptive filtering by using a generalized data windowing scheme. For the new modified CG algorithms, we show that the convergence speed is accelerated, the misadjustment and tracking capability comparable to those of the recursive least squares (RLS) algorithm are achieved. Computer simulations demonstrated in the framework of linear system modeling problem show the improvements of the new modifications.

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In this paper we investigate modeling capabilities of Bonferroni means and their generalizations. We will show that weighted Bonferroni means can model the concepts of hard and soft partial conjunction, and lead to several interesting special cases, with quite an intuitive interpretation.

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In information theory, entropies make up of the basis for distance and divergence measures among various probability densities. In this paper we propose a novel metric to detect DDoS attacks in networks by using the function of order α of the generalized (Rényi) entropy to distinguish DDoS attacks traffic from legitimate network traffic effectively. Our proposed approach can not only detect DDoS attacks early (it can detect attacks one hop earlier than using the Shannon metric while order α=2, and two hops earlier to detect attacks while order α=10.) but also reduce both the false positive rate and the false negative rate clearly compared with the traditional Shannon entropy metric approach.

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In this paper we provide a systematic investigation of a family of composed aggregation functions which generalize the Bonferroni mean. Such extensions of the Bonferroni mean are capable of modeling the concepts of hard and soft partial conjunction and disjunction as well as that of k-tolerance and k-intolerance. There are several interesting special cases with quite an intuitive interpretation for application.

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Multiwavelets are wavelets with multiplicity r, that is r scaling functions and r wavelets, which define multiresolution analysis similar to scalar wavelets. They are advantageous over scalar wavelets since they simultaneously posse symmetry and orthogonality. In this work, a new method for constructing multiwavelets with any approximation order is presented. The method involves the derivation of a matrix equation for the desired approximation order. The condition for approximation order is similar to the conditions in the scalar case. Generalized left eigenvectors give the combinations of scaling functions required to reconstruct the desired spline or super function. The method is demonstrated by constructing a specific class of symmetric and non-symmetric multiwavelets with different approximation orders, which include Geranimo-Hardin-Massopust (GHM), Daubechies and Alperts like multi-wavelets, as parameterized solutions. All multi-wavelets constructed in this work, posses the good properties of orthogonality, approximation order and short support.

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Precision edge feature extraction is a very important step in vision, Researchers mainly use step edges to model an edge at subpixel level. In this paper we describe a new technique for two dimensional edge feature extraction to subpixel accuracy using a general edge model. Using six basic edge types to model edges, the edge parameters at subpixel level are extracted by fitting a model to the image signal using least-.squared error fitting technique.

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Extensions of aggregation functions to Atanassov orthopairs (often referred to as intuitionistic fuzzy sets or AIFS) usually involve replacing the standard arithmetic operations with those defined for the membership and non-membership orthopairs. One problem with such constructions is that the usual choice of operations has led to formulas which do not generalize the aggregation of ordinary fuzzy sets (where the membership and non-membership values add to 1). Previous extensions of the weighted arithmetic mean and ordered weighted averaging operator also have the absorbent element 〈1,0〉, which becomes particularly problematic in the case of the Bonferroni mean, whose generalizations are useful for modeling mandatory requirements. As well as considering the consistency and interpretability of the operations used for their construction, we hold that it is also important for aggregation functions over higher order fuzzy sets to exhibit analogous behavior to their standard definitions. After highlighting the main drawbacks of existing Bonferroni means defined for Atanassov orthopairs and interval data, we present two alternative methods for extending the generalized Bonferroni mean. Both lead to functions with properties more consistent with the original Bonferroni mean, and which coincide in the case of ordinary fuzzy values.

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Fire is both a widespread natural disturbance that affects the distribution of species and a tool that can be used to manage habitats for species. Knowledge of temporal changes in the occurrence of species after fire is essential for conservation management in fire-prone environments. Two key issues are: whether postfire responses of species are idiosyncratic or if multiple species show a limited number of similar responses; and whether such responses to time since fire can predict the occurrence of species across broad spatial scales. We examined the response of bird species to time since fire in semiarid shrubland in southeastern Australia using data from surveys at 499 sites representing a 100-year chronosequence. We used nonlinear regression to model the probability of occurrence of 30 species with time since fire in two vegetation types, and compared species' responses with generalized response shapes from the literature. The occurrence of 16 species was significantly influenced by time since fire: they displayed six main responses consistent with generalized response shapes. Of these 16 species, 15 occurred more frequently in mid- or later-successional vegetation (>20 years since fire), and only one species occurred more often in early succession (<5 years since fire). The models had reasonable predictive ability for eight species, some predictive ability for seven species, and were little better than random for one species. Bird species displayed a limited range of responses to time since fire; thus a small set of fire ages should allow the provision of habitat for most species. Postfire successional changes extend for decades and management of the age class distribution of vegetation will need to reflect this timescale. Response curves revealed important seral stages for species and highlighted the importance of mid- to late-successional vegetation (>20 years). Although time since fire clearly influences the distribution of numerous bird species, predictive models of the spatial distribution of species in fire-prone landscapes need to incorporate other factors in addition to time since fire.