Risk factors for recurrent Mycobacterium ulcerans disease after exclusive surgical treatment in an Australian cohort

Objective: To describe risk factors for recurrence after exclusive surgical treatment of Mycobacterium ulcerans infection. Design, setting and participants: Prospective observational cohort study of all M. ulcerans cases managed with surgery alone at Barwon Health, a tertiary referral hospital, from 1 January 1998 to 31 December 2011. A random-effects Poisson regression model was used to assess rates and associations of treatment failure. Main outcome measures: Rates of treatment failure and rate ratios (RRs) for factors associated with treatment failure. Results: Of 192 patients with M. ulcerans infection, 50 (26%) had exclusive surgical treatment. Median age was 65.0 years (interquartile range [IQR], 45.5-77.7 years), and median duration of symptoms was 46 days (IQR, 26-90 days). There were 20 recurrences in 16 patients. For first lesions, the recurrence incidence rate was 41.8 (95% CI, 25.6-68.2) per 100 person-years, and median time to recurrence was 50 days (IQR, 30-171 days). Recurrence occurred ≤ 3 cm from the original lesion in 13 cases, and >3 cm in nine. On univariable analysis, age ≥60 years (RR 13.84; 95% CI, 2.21-86.68; P< 0.01), distal lesions (RR, 20.43; 95% CI, 1.97-212.22; P<0.01), positive histological margins (RR, 21.02; 95% CI, 5.51-80.26; P< 0.001), immunosuppression (RR, 17.97; 95% CI, 4.17-77.47; P <0.01) and duration of symptoms >75 days (RR, 10.13; 95% CI, 1.76-58.23; P =0.02) were associated with treatment failure. On multivariable analysis, positive margins (RR, 7.72; 95% CI, 2.71-22.01; P<0.001) and immunosuppression (RR, 6.45; 95% CI, 2.42-17.20; P =0.01) remained associated with treatment failure. Conclusions: Recurrence rates after exclusive surgical treatment of M. ulcerans disease in an Australian cohort are high, with increased rates associated with immunosuppression or positive histological margins.

A longitudinal study of the effect of psychosocial factors on exclusive breastfeeding duration

Objective
to examine the effect of psychosocial factors on exclusive breastfeeding duration to six months postpartum

Design
longitudinal, prospective questionnaire based study.

Setting
participants were recruited from a publically funded antenatal clinic located in the western metropolitan region of Melbourne, Victoria, Australia and asked to complete questionnaires at three time points; 32 weeks pregnancy, two months postpartum and six months postpartum.

Participants
the participants were 125 pregnant women aged 22–44 years.

Measurements and findings
psychosocial variables such as breastfeeding self-efficacy, body attitude, psychological adjustment, attitude towards pregnancy, intention, confidence and motivation to exclusively breastfeed and importance of exclusive breastfeeding were assessed using a range of psychometrically validated tools. Exclusive breastfeeding behaviour up to six months postpartum was also measured. At 32 weeks gestation a woman׳s confidence to achieve exclusive breastfeeding was a direct predictor of exclusive breastfeeding duration to six months postpartum. At two months postpartum, psychological adjustment and breastfeeding self-efficacy were predictive of exclusive breastfeeding duration. Finally, at six months postpartum, psychological adjustment, breastfeeding self-efficacy, confidence to maintain and feeling fat were directly predictive of exclusive breastfeeding duration.

Psychosocial correlates of exclusive breastfeeding duration to six months postpartum

 In Australia 17% of infants are exclusively breastfed to six months postpartum. This thesis examined the effect of psychosocial factors on women’s ability to maintain exclusive breastfeeding. The thesis demonstrated the paucity of research in this area and the importance of psychosocial factors such as breastfeeding self-efficacy and psychological adjustment in women’s exclusive breastfeeding outcomes.

Interventions designed to promote exclusive breastfeeding in high-income countries: a systematic review

Worldwide, women fail to reach the recommended exclusive breastfeeding target of 6 months postpartum. The objective of this study was to present a conceptual and methodological synthesis of interventions designed to promote exclusive breastfeeding to 6 months in high-income countries.

Farmers groups within extension networks in Northern Uganda : inclusive or exclusive?

Group extension methods are widely recognized as the most effective extension method in agricultural development internationally. Research in this area tends to look at group function, and factors that inhibit or promote successful group activity. Most development projects start with an analysis of whether groups exist or may need to be formed, and then focus on group function. However, very little research to date has considered the farmer group from a whole community context, when assessing knowledge and information dissemination in rural areas. This paper presents and discusses research finding from a case study with three communities in Gulu district of Northern Uganda, where household surveys were used to map networks within andbetween community members and external organizations identified as promoting agricultural development in the region. The potential impact of inclusion or exclusion in such a group within small communities emerged as a significant issue, as well as the strong disconnect between community and external organizational perceptions of group existence, function and impact.