Semiotic, rhetoric and democracy

This paper unites Deely’s call for a better understanding of semiotics with Jaeger’s insight into the sophists and the cultural history of the Ancient Greeks. The two bodies of knowledge are brought together to try to better understand the importance of rhetorical processes to political forms such as democracy. Jaeger explains how cultural expression, particularly poetry, changed through the archaic and classical eras to deliver, or at least to be commensurate with contemporary politics and ideologies. He explains how Plato (429-347 BCE) struggled against certain poetry and prose manifestations in his ambition to create a ‘perfect man’ – a humanity which would think in a way which would enable the ideal Republic to flourish. Deely’s approach based on Poinsot and Peirce presents a theoretical framework by means of which we can think of the struggle to influence individual and communal conceptualisation as a struggle within semiotics. This is a struggle over the ways reality is signified by signs. Signs are physical and mental indications which, in the semiotic tradition, are taken to produce human subjectivity – human ‘being’. Deely’s extensive body of work is about how these signs are the building blocks of realist constructions of understanding. This paper is concerned with the deliberate use of oral and written signs in rhetorical activity which has been deliberately crafted to change subjectivity. We discuss: (1) what thought and culture is in terms of semiotics and (2) Jaeger’s depiction of Ancient Greece as an illustration of the conjunction between culture and subjectivity. These two fields are brought together in order to make the argument that rhetoric can be theorised as the deliberate harnessing of semiotic affects. The implication is that the same semiotic, subjectivity-changing potency holds for 21st century rhetoric. However fourth century BCE Athens is the best setting for a preliminary discussion of rhetoric as deliberate semiotic practice because this was when rhetoric was most clearly understood for what it is. By contrast a discussion concentrating on modern rhetoric: public relations; advertising; lobbying; and public affairs would open wider controversies requiring considerably more complex explanation.

Hedgehog partial agonism drives warburg-lie metabolism in muscle and brown fat

Diabetes, obesity, and cancer affect upward of 15% of the world’s population. Interestingly, all three diseases juxtapose dysregulated intracellular signaling with altered metabolic state. Exactly which genetic factors define stable metabolic set points in vivo remains poorly understood. Here, we show that hedgehog signaling rewires cellular metabolism. We identify a cilium-dependent Smo-Ca2+-Ampk axis that triggers rapid Warburg-like metabolic reprogramming within minutes of activation and is required for proper metabolic selectivity and flexibility. We show that Smo modulators can uncouple the Smo-Ampk axis from canonical signaling and identify cyclopamine as one of a new class of “selective partial agonists,” capable of concomitant inhibition of canonical and activation of noncanonical hedgehog signaling. Intriguingly, activation of the Smo-Ampk axis in vivo drives robust insulin-independent glucose uptake in muscle and brown adipose tissue. These data identify multiple noncanonical endpoints that are pivotal for rational design of hedgehog modulators and provide a new therapeutic avenue for obesity and diabetes.

We ‘are’ rhetoric. Get over it!

This paper argues that a better understanding of public relations would help us to get an urgently needed better understanding of people. It explains why public relations should be considered the contemporary manifestation of the millennia-old art of rhetoric which in turn should be considered the basis of, at least western culture. This article introduces a thesis that understanding rhetoric properly will lead to the best way of understanding public relations properly. It will critique existing writers about the rhetoric to public relations nexus to suggest that there is a crucial need to more carefully consider the true relevance
of massively organised deliberate persuasive discourse. The urgency is because few of these commentators quite capture the extent to which public relations and related  activities are creating us. It will explain why we are almost unconscious of this process and it will point out that by contrast ancient sophists and the more accomplished pre-modern rhetoricians have always been aware of this ‘construction of people process’. The approach of this paper is premised on the observation of classicist Werner Jaeger who explains that rhetoric is at the centre of being human. When explaining the use of  grammar, rhetoric and dialectic by Greek Enlightenment sophists he writes that: “This educational technique is one of the greatest discoveries which the mind of man has ever made: it was not until it explored these three of its activities that the mind apprehended the hidden law of its own structure.” (Jaeger, 1947:314)

The role of fear of self and responsibility in obsessional doubt processes: a bayesian hierarchical model

The literature concerning obsessive-compulsive disorder (OCD) indicates that obsessions frequently imply negative evaluative beliefs regarding the self. The construct of the feared self has been used to describe the set of harmful attributes an individual worries they may possess. This study aimed to partially replicate previous research that demonstrated a relationship between feared-self beliefs and obsessional doubt in OCD-relevant contexts. The relationship between perceptions of personal responsibility and associated levels of doubt was also examined. Nonclinical participants (N = 221; 155 female; Mage = 26.4, SD = 9.2) were presented with vignettes related to checking and non OCD-relevant themes, which quantified doubt through the presentation of alternating reality-based (i.e., sensory) and possibility-based information. Of the total sample, 112 participants were randomly allocated to a personally relevant condition (in which the action implied in the vignettes was completed by the reader), and 109 were allocated to a second, other-relevant, condition (in which the action implied in the vignettes was completed by a proximal other). The results provided support for reasoning processes implicated in OCD, suggesting that feared-self beliefs may partially contribute to heightened levels of doubt in response to possibility vs. reality-based information in OCD-relevant contexts. Personal relevance contributed to greater baseline levels of doubt, but not to greater responses to the reality- and possibility-based statements accompanying the OCD-relevant vignette. Implications for theory and future research are discussed.