Second city syndrome : media reportage of urban rankings

This paper investigates the popularly reported phenomenon of city rankings and, in particular, the category of the ‘second city’ that regularly features as part of this prolific evaluative discourse. Our paper proposes that the category ‘second city’ has a specific analytical value that has to date been underestimated in academic accounts (particularly in the confusing, interchangeable use of ‘second-tier’, ‘secondary’ and ‘second cities’ in the dominant urban studies literature). Instead, we are interested in how second city identifications permeate popular forms of urban comparison in some places.

The example of Melbourne (Australia) is used to investigate how second city identities are historically sustained through evaluative media representations. In particular we examine how, through their reportage of various world city rankings, metropolitan newspapers reveal and articulate a ‘second city consciousness’. How do media institutions, and more specifically, media reports, frame these urban rankings in such a way to confirm Melbourne’s similarity to other globalised places (i.e. proposing its status as a ‘world city’), yet also as a city also marked by a particular historical specificity? And how do they draw on already existing popular and political traditions of urban comparison? This article will identify and analyse the role of newspapers in perpetuating both formal and informal urban comparisons.

Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and their role in inflammation associated with metabolic syndrome and cancer

Linoleic acid (LA) is a major constituent of low-density lipoproteins. An essential fatty acid, LA is a polyunsaturated fatty acid, which is oxidised by endogenous enzymes and reactive oxygen species in the circulation. Increased levels of low-density lipoproteins coupled with oxidative stress and lack of antioxidants drive the oxidative processes. This results in synthesis of a range of oxidised derivatives, which play a vital role in regulation of inflammatory processes. The derivatives of LA include, hydroxyoctadecadienoic acids, oxo-​octadecadienoic acids, epoxy octadecadecenoic acid and epoxy-keto-octadecenoic acids. In this review, we examine the role of LA derivatives and their actions on regulation of inflammation relevant to metabolic processes associated with atherogenesis and cancer. The processes affected by LA derivatives include, alteration of airway smooth muscles and vascular wall, affecting sensitivity to pain, and regulating endogenous steroid hormones associated with metabolic syndrome. LA derivatives alter cell adhesion molecules, this initial step, is pivotal in regulating inflammatory processes involving transcription factor peroxisome proliferator-activated receptor pathways, thus, leading to alteration of metabolic processes. The derivatives are known to elicit pleiotropic effects that are either beneficial or detrimental in nature hence making it difficult to determine the exact role of these derivatives in the progress of an assumed target disorder. The key may lie in understanding the role of these derivatives at various stages of development of a disorder. Novel pharmacological approaches in altering the synthesis or introduction of synthesised LA derivatives could possibly help drive processes that could regulate inflammation in a beneficial manner. Chemical Compounds: Linoleic acid (PubChem CID: 5280450), 9- hydroxyoctadecadienoic acid (PubChem CID: 5312830), 13- hydroxyoctadecadienoic acid (PubChem CID: 6443013), 9-oxo-​octadecadienoic acid (PubChem CID: 3083831), 13-oxo-​octadecadienoic acid (PubChem CID: 4163990), 9,10-epoxy-12-octadecenoate (PubChem CID: 5283018), 12,13-epoxy-9-keto-10- trans -octadecenoic acid (PubChem CID: 53394018), Pioglitazone (PubChem CID: 4829).