Early events of HIV-1 infection : can signalling be the next therapeutic target?

Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.

Digital ubiquity in the Anthropocene : the non-anthropocentric anthropology of Massimo Canevacci

The work of Massimo Canevacci is undoubtedly one of the most compelling examples of transdisciplinary thinking when applied to the interdisciplinary effort of expanding the boundaries of a discipline. His work engages with geography, art, technology, media, psychology, etc – a true kaleidoscope of perspectives. The synapses created by the transversal connections he makes across a multiplicity of epistemologies are catalytic. To follow the logical itinerary created by his scholarly inquiry is to be taken on a journey that leaves none of our pre-conceptions untouched.