Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

Eukaryotic cells prevent copper-induced, free radical damage to cell components by employing copper-binding proteins and transporters that minimize the likelihood of free copper ions existing in the cell. In the cell, copper is actively transported from the cytoplasm during the biosynthesis of secreted coppercontaining proteins and, as a protective measure, when there is an excess of copper. In humans, this is accomplished by two related copper-transporting ATPases (ATP7A and ATP7B), which are the affected genes in two distinct human genetic disorders of copper transport, Menkes disease (copper deficiency) and Wilson disease (copper toxicosis). The study of these ATPases has revealed their molecular mechanisms of copper transport and their roles in physiological copper homeostasis. Both ATP7A and ATP7B are expressed in specific brain regions and neurological abnormalities are important clinical features in Menkes and Wilson disease.

Automatic parallelisation and execution of applications on clusters

Parallel execution is a very efficient means of processing vast amounts of data in a small amount of time. Creating parallel applications has never been easy, and requires much knowledge of the task and the execution environment used to execute parallel processes. The process of creating parallel applications can be made easier through using a compiler that automatically parallelises a supplied application. Executing the parallel application is also simplified when a well designed execution environment is used. Such an execution environment provides very powerful operations to the programmer transparently. Combining both a parallelising compiler and execution environment and providing a fully automated parallelisation and execution tool is the aim of this research. The advantage of using such a fully automated tool is that the user does not need to provide any additional input to gain the benefits of parallel execution. This report shows the tool and how it transparently supports the programmer creating parallel applications and supports their execution.

Critical factors influencing employment: a study of small manufacturing firms in South-East Australia

Compliance with legislation has been highlighted as a factor influencing the reluctance of small and medium sized enterprises to take on new employees. With the objective of determining factors influencing smaller firms in their employment decisions, mailed questionnaires were used to survey small to medium manufacturing businesses in the Australian States of Victoria and New South Wales. Significant critical factors and deterrents to further employment were identified.

Monotone approximation of aggregation operators using least squares splines

The need for monotone approximation of scattered data often arises in many problems of regression, when the monotonicity is semantically important. One such domain is fuzzy set theory, where membership functions and aggregation operators are order preserving. Least squares polynomial splines provide great flexbility when modeling non-linear functions, but may fail to be monotone. Linear restrictions on spline coefficients provide necessary and sufficient conditions for spline monotonicity. The basis for splines is selected in such a way that these restrictions take an especially simple form. The resulting non-negative least squares problem can be solved by a variety of standard proven techniques. Additional interpolation requirements can also be imposed in the same framework. The method is applied to fuzzy systems, where membership functions and aggregation operators are constructed from empirical data.

Cultural issues in online learning - is blended learning a possible solution?

The emergence of cross-cultural classrooms has been steadily increasing in Australian tertiary institutions, due to the growing population of international students enrolling to complete their degrees. This increase in international students has signified a change in the student demographics, thus recognizing the differences in students’ learning styles, and indicating that a more flexible approach is needed for learner content delivery. Research has suggested that students from different cultures have varying compatibility with different learning environments. With tertiary institutions now expanding towards the online forum for delivery of units, these compatibilities of students are even more evident. Hence, in order to ensure that all students are able to participate in this domain, preparations are needed to accommodate all cultural types. Therefore with the emphasis on creating flexible learning environments for all students the blended learning approach has been suggested as a solution.

Fitting generated aggregation operators to empirical data

This paper treats the problem of fitting general aggregation operators with unfixed number of arguments to empirical data. We discuss methods applicable to associative operators (t-norms, t-conorms, uninorms and nullnorms), means and Choquet integral based operators with respect to a universal fuzzy measure. Special attention is paid to k-order additive symmetric fuzzy measures.

Software warehouse: its design management and application

To have an effective and efficient mechanism to store, manage and utilize software sources is essential to the automation of software engineering. The paper presents an innovative approach in managing software resources using software warehouse where software assets are systematically accumulated, deposited, retrieved, packaged, managed and utilized, driven by data-mining and OLAP technologies. The results lead to streamlined high efficient software development process and enhance the productivity in response to modern challenges of the design and development of software applications.

Preemptive job scheduling policy for distributively-owned workstation clusters

Cluster computing has come to prominence as a cost-effective parallel processing tool for solving many complex computational problems. In this paper, we propose a new timesharing opportunistic scheduling policy to support remote batch job executions over networked clusters to be used in conjunction with the Condor Up-Down scheduling algorithm. We show that timesharing approaches can be used in an opportunistic setting to improve both mean job slowdowns and mean response times with little or no throughput reduction. We also show that the proposed algorithm achieves significant improvement in job response time and slowdown as compared to exiting approaches and some recently proposed new approaches.

What will affect software reuse: a causal model analysis

Software reuse is an important topic due to its potential benefits in increasing product quality and decreasing cost. Although more and more people are aware that not only technical issues, but also nontechnical issues are important to the success of software reuse, people are still not certain which factors will have direct effect on the success of reuse. In this paper, we applied a causal discovery algorithm to the software reuse survey data [2]. Ensemble strategy is incorporated to locate a probable causal model structure for software reuse, and find all those factors which have direct effect on the success of reuse. Our discovery results reinforced some conclusions of Morisio et al. and found some new conclusions which might significantly improve the odds of a reuse project succeeding.

The effectiveness of the bills of quantities in Australia

The research aimed to explore if the information in the Australian Bill of Quantities (BOQ) was presented in a manner that could be utilized effectively by the end user. Populations surveyed; contractor, subcontractor and quantity surveyor, agree that the BOQ is a document that should be retained and would be used if produced. The adequacy of information was found to be in question by the users of the BOQ. The locational information is not adequate for its purpose. The quantities are neither located in the structure nor broken down into zones so useful for material ordering, daily work production management and cost management tasks. This information provided was requested to be supplemented by the inclusion of drawings, drawing  numbers and the zonal breakdown of quantities in a smaller number of BOQ items. End users concluded that the current information contained within the BOQ is efficient but not effective. Not one participant — quantity surveyors, contractors and subcontractors — believed they were adequately consulted or represented in production of the latest StandardMethod of Measurement (SMM). It is concluded that there is a need for end-users such as contractors and subcontractors to have greater input into the design, development and implementation of the Australian SMM. The resultant “consensus document” could then be an effective communication tool that is used for estimating, planning, purchasing and site management.

Validation of the use of input-output data for embodied energy analysis of the Australian construction industry

This paper evaluates a recently developed hybrid method for the embodied energy analysis of the Australian construction industry. It was found that the truncation associated with process analysis can be up to 80%, whilst the use of input-output analysis alone does not always provide a perfect model for replacing process data. There is also a considerable lack in the quantity and possibly quality of process data currently available. These findings suggest that current best-practice methods are sufficiently accurate for most typical applications, but this is heavily dependant upon data quality and availability. The hybrid method evaluated can be used for the optimisation of embodied energy and for identifying opportunities for improvements in energy efficiency.

Asian biotechnology hub

Focuses on the development of biotechnology in Asia. Factors that make Asia a suitable location for global biotech investment; Asian countries leading in biotechnology development; Development of a biotechnology hub in Singapore; Growth in agricultural biotechnology research in Malaysia; Projects in the biotechnology sector in South Korea.

Australian and New Zealand untapped biotechnology opportunities

Focuses on biotechnology opportunities in Australia and New Zealand. Increase in investments into the Australian and New Zealand biotechnology sector; Rank of Australia among biomedical research and development cost-effective countries; Application of New Zealand's biotechnology research in fields such as forestry and human healthcare.

Strategic Australian biotechnology opportunities

Discusses the biotechnology opportunities in Australia as of April 2005. Specific core activities of Australian biotechnology companies; Number of biotechnology companies listed on the Australian Stock Exchange on September 30, 2004; Mutual recognition arrangements that exist with Australia and key international regulatory authorities.

Current status of bioindustry in South Korea

Presents information on the status of the biotechnology industry in South Korea in 2005. Stages of the country's bioindustry; Research portfolio; Strategies to gain competitive advantage on a global basis; Goals of the industry's generation projects.