New way of seeing things : Ernst Troeltsch and the theological agenda

The aim of this thesis, as set out in the Introduction, is to assess the (seminal) significance of Troeltsch as one who set the agenda for twentieth century theology, particularly modern sociopolitical theology, and whose thought still has a special relevance. The first main chapter deals with the implications of the philosophy of history for theology. The Protestant theological orthodoxy of Troeltsch's time was essential ahistorical: he thought this to be untenable. Theology had to come to terms with the historical method, which was ‘a leaven which transforms everything, and finally bursts all previous forms of theological method.’ This chapter discusses Troeltsch's work concerning the principles, the cultural matrix, and the philosophy of history. The second main chapter examines another main concern of Troeltsch, namely, the status of Christianity vis-a-vis other religions. The background to this was the increasing awareness of the existence of other religions and the question of relativity and universality which this posed. Troeltschfs major response was Die Absolutheit des Christentums in which the ideas of essence, Europeanism, and absolutism were discussed, The third, and longest, chapter looks at the impact of social theory on theology. Sociology gave Troeltsch ‘a new way of seeing things’, and this new perspective is to be seen pre-eminently in The Social Teaching of the Christian Churches. Discussion of this centres on the three main concepts that Troeltsch delineated, compromise, natural law, and church/sect typology.

New cutting-planes for the time-and/or precedence-constrained ATSP and directed VRP

In this paper, we introduce five classes of new valid cutting planes for the precedence-constrained (PC) and/or time-window-constrained (TW) Asymmetric Travelling Salesman Problems (ATSPs) and directed Vehicle Routing Problems (VRPs). We show that all five classes of new inequalities are facet-defining for the directed VRP-TW, under reasonable conditions and the assumption that vehicles are identical. Similar proofs can be developed for the VRP-PC. As ATSP-TW and PC-ATSP can be formulated as directed identical-vehicle VRP-TW and PC-VRP, respectively, this provides a link to study the polyhedral combinatorics for the ATSP-TW and PC-ATSP. The first four classes of these new cutting planes are cycle-breaking inequalities that are lifted from the well-known D^-_k and D⁺_k inequalities (see Grötschel and Padberg in Polyhedral theory. The traveling salesman problem: a guided tour of combinatorial optimization, Wiley, New York, 1985). The last class of new cutting planes, the TW ₂ inequalities, are infeasible-path elimination inequalities. Separation of these constraints will also be discussed. We also present prelimanry numerical results to demonstrate the strengh of these new cutting planes.

Lateral strength of zero bond masonry walls subjected to wind loads

Masonry walls are usually laid with the individual masonry units along a course overlapping units in the course below. Commonly, the perpend joints in the course occur above the mid-points of the units below to form a ‘half-bond’ or above a third point to form a ‘third-bond’. The amount of this overlap has a profound influence on the strength of a wall supported on three or four sides, where lateral pressures from wind cause combined vertical and horizontal flexure. Where masonry units are laid with mortar joints, the torsional shear bond resistance between the mortar and overlapping units largely determines the horizontal flexural strength. If there is zero bond strength between units, then the horizontal flexural strength is derived from the frictional resistance to torsion on the overlapping bed-faces of the units. This thesis reports a theoretical and experimental investigation into the frictional properties of overlapping units when subjected to combinations of vertical and horizontal moments and vertical axial compression. These basic properties were used to develop a theory to predict the lateral strength of walls supported on two, three or four sides. A plastic theory of behaviour was confirmed by experiment. The theory was then used to determine maximum unbraced panel sizes for particular boundary conditions. Design charts were developed to determine temporary bracing requirements for panels during construction.

Threshold effects of glucose transporter-4 (GLUT4) deficiency on cardiac glucose uptake and development of hypertrophy

The aim of this study was to investigate the metabolic and structural consequences of a decrease in glucose transporter-4 (GLUT4) levels on the heart. The CreLoxP system was utilised to delete GLUT4 in muscle tIssue including heart. The presence of the PGK-neoR cassette in the GLUT4-Lox mice resulted in reduced expression in all tIssues to levels 15-30% of wild-type control mice. In mice expressing Cre recombinase, there was a further reduction of GLUT4 in cardiac tIssue to almost undetectable levels. Cardiac glucose uptake was measured basally and during a uglycaemic/hyperinsulinaemic clamp using 2-deoxy-[1-(14)C]glucose. Insulin-stimulated glucose uptake was normal in hearts expressing 15% of normal GLUT4 levels but markedly reduced in mice with more profound reduction in GLUT4. Cardiac enlargement occurred only when GLUT4 levels were less than 5% of normal values. In heart there is a threshold level of GLUT4 above which insulin-stimulated glucose uptake is maintained. As little as 5% of normal GLUT4 levels expressed in heart is sufficient to prevent the development of cardiac hypertrophy. 2-deoxy-[1-14C]glucose. Insulin-stimulated glucose uptake was normal in hearts expressing 15% of normal GLUT4 levels but markedly reduced in mice with more profound reduction in GLUT4. Cardiac enlargement occurred only when GLUT4 levels were less than 5% of normal values. In heart there is a threshold level of GLUT4 above which insulin-stimulated glucose uptake is maintained. As little as 5% of normal GLUT4 levels expressed in heart is sufficient to prevent the development of cardiac hypertrophy.

Vorschlag zur Ergänzung der Bewertung des sommerlichen Wärmeschutzes nach DIN 4108-2 bei Verwaltungsgebäuden: Korrekturwerte für den zulässigen Höchstwert des Sonneneintragskennwertes Szul

In DIN 4108-2 ist ein Nachweis zum sommerlichen Wrmeschutz in Gebuden enthalten, der seit Inkrafttreten der Energieeinsparverordnung (EnEV) 2002 gesetzlich vorgeschrieben ist. Dabei handelt es sich um ein einfaches, parametrisiertes Verfahren, bei dem ein Sonneneintragskennwert S_vorh berechnet und mit dem maximal zulssigen Wert S_zul verglichen wird. Diese Formulierung ist im Ansatz sehr gut, allerdings offensichtlich für Wohngebude entwickelt worden. Im Nichtwohngebudebereich sind dagegen höhere Wrmeeintrge und verminderte Lüftungsmöglichkeiten zu erwarten. Aus diesem Grund ist eine Korrektur des Sonneneintragskennwertes S_zul für Verwaltungsgebude notwendig, die Ermittlung von entsprechenden Korrekturwerten ist Inhalt dieser Veröffentlichung.

On the minimum cardinality problem in intensity modulated radiotherapy

The thesis examines an optimisation problem that appears in the treatment planning of intensity modulated radiotherapy. An approach is presented which solved the optimisation problem in question while also extending the approach to execute in a massively parallel environment. The performance of the approach presented is among the fastest available.