Spatial coordinated medium sharing: Optimal access control management in drive-thru internet

Driven by the ever-growing expectation of ubiquitous connectivity and the widespread adoption of IEEE 802.11 networks, it is not only highly demanded but also entirely possible for in-motion vehicles to establish convenient Internet access to roadside WiFi access points (APs) than ever before, which is referred to as Drive-Thru Internet. The performance of Drive-Thru Internet, however, would suffer from the high vehicle mobility, severe channel contentions, and instinct issues of the IEEE 802.11 MAC as it was originally designed for static scenarios. As an effort to address these problems, in this paper, we develop a unified analytical framework to evaluate the performance of Drive-Thru Internet, which can accommodate various vehicular traffic flow states, and to be compatible with IEEE 802.11a/b/g networks with a distributed coordination function (DCF). We first develop the mathematical analysis to evaluate the mean saturated throughput of vehicles and the transmitted data volume of a vehicle per drive-thru. We show that the throughput performance of Drive-Thru Internet can be enhanced by selecting an optimal transmission region within an AP's coverage for the coordinated medium sharing of all vehicles. We then develop a spatial access control management approach accordingly, which ensures the airtime fairness for medium sharing and boosts the throughput performance of Drive-Thru Internet in a practical, efficient, and distributed manner. Simulation results show that our optimal access control management approach can efficiently work in IEEE 802.11b and 802.11g networks. The maximal transmitted data volume per drive-thru can be enhanced by 113.1% and 59.5% for IEEE 802.11b and IEEE 802.11g networks with a DCF, respectively, compared with the normal IEEE 802.11 medium access with a DCF.

Job scheduling policy for high throughput grid computing

The growing computational power requirements of grand challenge applications has promoted the need for merging high throughput computing and grid computing principles to harness computational resources distributed across multiple organisations. This paper identifies the issues in resource management and scheduling in the emerging high throughput grid computing context. We also survey and study the performance of several space-sharing and time-sharing opportunistic scheduling policies that have been developed for high throughput computing.

Load balance algorithms for anycast

Increasingly, replicated anycast servers are being used to deliver network applications and service ever increasing user requests. Therefore, the strategies used to guarantee network bandwidth prerequisites and perform load balancing across the nodes of an anycast group are critical to the performance of online applications. In this paper, we model user requests, network congestion and latency, and server load using a combination of hydro-dynamics and queuing theory to develop an efficient job distribution strategy. Current, anycast research does not explicitly consider the system load of nodes within an anycast groups when distributing requests. Therefore, the performance of a heavily loaded anycast system can quickly become congested and uneven as jobs are routed to closely linked nodes which are already saturated with requests. In comparison, the nodes of further away systems remain relatively unused because of other issues such as network bandwidth and latency during these times. Our system redirects requests from busy systems to the idle, remotely linked nodes, to process requests faster in spite of slower network access. Using an empirical study, we show this technique can improve request performance, and throughput with minimal network probing overhead.

Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites

Consumption of a Western diet rich in saturated fats is associated with obesity and insulin resistance. In some insulin-resistant phenotypes this is associated with accumulation of skeletal muscle fatty acids. We examined the effects of diets high in saturated fatty acids (Sat) or n-6 polyunsaturated fatty acids (PUFA) on skeletal muscle fatty acid metabolite accumulation and whole-body insulin sensitivity. Male Sprague-Dawley rats were fed a chow diet (16% calories from fat, Con) or a diet high (53%) in Sat or PUFA for 8 wk. Insulin sensitivity was assessed by fasting plasma glucose and insulin and glucose tolerance via an oral glucose tolerance test. Muscle ceramide and diacylglycerol (DAG) levels and triacylglycerol (TAG) fatty acids were also measured. Both high-fat diets increased plasma free fatty acid levels by 30%. Compared with Con, Sat-fed rats were insulin resistant, whereas PUFA-treated rats showed improved insulin sensitivity. Sat caused a 125% increase in muscle DAG and a small increase in TAG. Although PUFA also resulted in a small increase in DAG, the excess fatty acids were primarily directed toward TAG storage (105% above Con). Ceramide content was unaffected by either high-fat diet. To examine the effects of fatty acids on cellular lipid storage and glucose uptake in vitro, rat L6 myotubes were incubated for 5 h with saturated and polyunsaturated fatty acids. After treatment of L6 myotubes with palmitate (C16:0), the ceramide and DAG content were increased by two- and fivefold, respectively, concomitant with reduced insulin-stimulated glucose uptake. In contrast, treatment of these cells with linoleate (C18:2) did not alter DAG, ceramide levels, and glucose uptake compared with controls (no added fatty acids). Both 16:0 and 18:2 treatments increased myotube TAG levels (C18:2 vs. C16:0, P < 0.05). These results indicate that increasing dietary Sat induces insulin resistance with concomitant increases in muscle DAG. Diets rich in n-6 PUFA appear to prevent insulin resistance by directing fat into TAG, rather than other lipid metabolites.

Water repellency, near-saturated infiltration and preferential solute transport in a macroporous clay soil

Little attention has been paid to the possibility that soil water repellency could enhance non-equilibrium water flow and solute transport through macropores present in structured clay soils. In this study, we measured infiltration and solute transport in a clay soil under near-saturated conditions in both the field using tension infiltrometers and in the laboratory on undisturbed soil columns. Measurements were made on adjacent plots under grass and continuous arable cultivation. Steady-state field infiltration rates measured using water and ethanol as the infiltrating fluids demonstrated that the soil macroporosity under grass was better developed, but that much of the structural pore system was inactive due to water repellency. No water repellency was detected on the arable plot disturbed by tillage. Dye tracing showed that the conducting macroporosity was largely comprised of earthworm channels in the grassed plot and inter-aggregate voids resulting from ploughing in the arable plot. Tracer breakthrough curves measured on field-dry soil indicated rapid macropore transport in columns taken from both plots, although the degree of non-equilibrium transport appeared somewhat stronger under grass. This result, which was attributed to water repellency, was also consistent with the larger flow-weighted mean pore size found in the field infiltration experiments. It is concluded that water repellency in undisturbed structured clay soils can have significant effects on the occurrence of non-equilibrium water and solute transport in macropores.

'Iron-saturated' lactoferrin is a potent natural adjuvant for augmenting cancer chemotherapy

Bovine lactoferrin (bLf), an iron-containing natural defence protein found in bodily secretions, has been reported to inhibit carcinogenesis and the growth of tumours. Here, we investigated whether natural bLf and iron-saturated forms of bLf differ in their ability to augment cancer chemotherapy. bLf was supplemented into the diet of C57BL/6 mice that were subsequently challenged subcutaneously with tumour cells, and treated by chemotherapy. Chemotherapy eradicated large (0.6 cm diameter) EL-4 lymphomas in mice that had been fed iron-saturated bLf (here designated Lf(+)) for 6 weeks prior to chemotherapy, but surprisingly not in mice that were fed lesser iron-saturated forms of bLf, including apo-bLf (4% iron saturated), natural bLf (approximately 15% iron saturated) and 50% iron-saturated bLf. Lf(+)-fed mice bearing either EL-4, Lewis lung carcinoma or B16 melanoma tumours completely rejected their tumours within 3 weeks following a single injection of either paclitaxel, doxorubicin, epirubicin or fluorouracil, whereas mice fed the control diet were resistant to chemotherapy. Lf(+) had to be fed to mice for more than 2 weeks prior to chemotherapy to be wholly effective in eradicating tumours from all mice, suggesting that it acts as a competence factor. It significantly reduced tumour vascularity and blood flow, and increased antitumour cytotoxicity, tumour apoptosis and the infiltration of tumours by leukocytes. Lf(+) bound to the intestinal epithelium and was preferentially taken up within Peyer's patches. It increased the production of Th1 and Th2 cytokines within the intestine and tumour, including TNF, IFN-gamma, as well as nitric oxide that have been reported to sensitize tumours to chemotherapy. Importantly, it restored both red and white peripheral blood cell numbers depleted by chemotherapy, potentially fortifying the mice against cancer. In summary, bLf is a potent natural adjuvant and fortifying agent for augmenting cancer chemotherapy, but needs to be saturated with iron to be effective.

On the effective mechanical properties of fluid-saturated composites : a homogenization approach

Composites containing saturated fluid are widely distributed in nature, such as saturated rocks, colloidal materials and biological cells. In the study to determine effective mechanical properties of fluid-saturated composites, a micromechanical model and a multi-scale homogenization-based model are developed. In the micromechanical model the internal fluid pressure is generated by applying eigenstrains in the domain of the fluid phase and the explicit expressions of effective bulk modulus and shear modulus are obtained. Meanwhile a multi-scale homogenization theory is employed to develop the homogenization-based model on determination of effective properties at the small scale in a unit cell level. Applying the two proposed approaches, the effects of the internal pressure of hydrostatic fluid on effective properties are further investigated.

Antioxidant enzyme activities of iron-saturated bovine lactoferrin (Fe-bLf) in human gut epithelial cells under oxidative stress

Chemoprevention by dietary constituents in the form of functional food has emerged as a novel approach to control inflammatory diseases and cancers. Recently we reported for the first time that iron content is a critical determinant in the anti-tumour activity of bovine milk lactoferrin (bLf). We therefore wanted to evaluate the chemo-preventative efficacy of Apo-bLF and 100% iron-saturated bLF (Fe-bLF) on hydrogen peroxide (H2O 2)-induced colon carcinogenesis, and their influence on antioxidant enzyme activities within colon carcinogenesis. This was undertaken through observing how oxidative stress induced by H2O2 alters antioxidant enzyme activity within HT29 colon cancer cells, and then observing changes in this activity by treatments with the different antioxidants ascorbic acid (AA), Apo-bLF and Fe-bLF. All antioxidant enzymes (catalase, glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-s-transferase (GsT) and superoxide dismutase (SOD)) appeared to be increased within HT29 cells, even prior to H2O2 exposure, and all enzymes showed significant decreased activity when cells were treated with the antioxidants AA, Apo-bLF or Fe-bLF, with or without H2O2 exposure. The results indicate that all three antioxidants have the ability to scavenge ROS, lower antioxidant enzyme activities within already excited states, and possibly allow colon cancer cells to be overcome by oxidative stress that would normally be prevented, perhaps leading to damage and potential apoptosis of the cancer cells. In conclusion, the anti-oxidative effects of Apo-bLF and Fe-bLf studied for the first time, show dynamic changes that may allow for necessary protection from imbalanced oxidative conditions, and potential at reducing the ability of cancer cells to protect themselves from oxidative stress states.

On the maximum throughput of two-hop wireless network coding

Network coding has shown the promise of significant throughput improvement. In this paper, we study the throughput of two-hop wireless network coding and explore how the maximum throughput can be achieved under a random medium access scheme. Unlike previous studies, we consider a more practical network where the structure of overhearing status between the intended receivers and the transmitters is arbitrary. We make a formal analysis on the network throughput using network coding upon the concept of network coding cliques (NCCs). The analysis shows that the maximum normalized throughput, subject to fairness requirement, is n/n+m, where n is the number of transmitters and m is the number of NCCs in a 2-hop wireless network. We have also found that this maximum throughput can be achieved under a random medium access scheme when the medium access priority of the relay node is equal to the number of NCCs in the network. Our theoretical findings have been validated by simulation as well.