Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-[gamma] coactivator-1 and peroxisome proliferator-activated receptor-[alpha] in skeletal muscle

The peroxisome proliferator-activated receptor (PPAR)-γ coactivator-1 (PGC-1) can induce mitochondria biogenesis and has been implicated in the development of oxidative type I muscle fibers. The PPAR isoforms α, β/δ, and γ control the transcription of genes involved in fatty acid and glucose metabolism. As endurance training increases skeletal muscle mitochondria and type I fiber content and fatty acid oxidative capacity, our aim was to determine whether these increases could be mediated by possible effects on PGC-1 or PPAR-α, -β/δ, and -γ. Seven healthy men performed 6 weeks of endurance training and the expression levels of PGC-1 and PPAR-α, -β/δ, and -γ mRNA as well as the fiber type distribution of the PGC-1 and PPAR-α proteins were measured in biopsies from their vastus lateralis muscle. PGC-1 and PPAR-α mRNA expression increased by 2.7- and 2.2-fold (P < 0.01), respectively, after endurance training. PGC-1 expression was 2.2- and 6-fold greater in the type IIa than in the type I and IIx fibers, respectively. It increased by 2.8-fold in the type IIa fibers and by 1.5-fold in both the type I and IIx fibers after endurance training (P < 0.015). PPAR-α was 1.9-fold greater in type I than in the II fibers and increased by 3.0-fold and 1.5-fold in these respective fibers after endurance training (P < 0.001). The increases in PGC-1 and PPAR-α levels reported in this study may play an important role in the changes in muscle mitochondria content, oxidative phenotype, and sensitivity to insulin known to be induced by endurance training.

Toughening of a carbon-fibre composite using electrospun poly(Hydroxyether of Bisphenol A) nanofibrous membranes through inverse phase separation and inter-domain etherification

The interlaminar toughening of a carbon fibre reinforced composite by interleaving a thin layer (~20 microns) of poly(hydroxyether of bisphenol A) (phenoxy) nanofibres was explored in this work. Nanofibres, free of defect and averaging several hundred nanometres, were produced by electrospinning directly onto a pre-impregnated carbon fibre material (Toray G83C) at various concentrations between 0.5 wt % and 2 wt %. During curing at 150 °C, phenoxy diffuses through the epoxy resin to form a semi interpenetrating network with an inverse phase type of morphology where the epoxy became the co-continuous phase with a nodular morphology. This type of morphology improved the fracture toughness in mode I (opening failure) and mode II (in-plane shear failure) by up to 150% and 30%, respectively. Interlaminar shear stress test results showed that the interleaving did not negatively affect the effective in-plane strength of the composites. Furthermore, there was some evidence from DMTA and FT-IR analysis to suggest that inter-domain etherification between the residual epoxide groups with the pendant hydroxyl groups of the phenoxy occurred, also leading to an increase in glass transition temperature (~7.5 °C).

Integration of roof-top solar photovoltaic systems into the low voltage distribution network

The advancement in solar photovoltaic (PV) technology, the cost and efficiency of PVs have encouraged users worldwide to adopt more and more PVs as it is free from greenhouse gas emissions and unlimited in nature. Integration of roof-top solar PV systems is currently emerging rapidly in Australia as the governments are giving attractive incentives and encouraging households to build a sustainable climate-friendly society for the future. The key major barriers to the integration of roof-top solar PV systems are the uncertainties in the performance of the low voltage distribution network due to the intermittent nature of solar PV sources. In this paper, a model was developed to investigate the potential technical impacts of integrating roof-top solar PV systems into the low voltage distribution network in a subtropical climate. The results show that integration of roof-top solar PV in the customer premises causes uncertainties such as voltage fluctuations, phase unbalance, distribution transformer overloading, reactive power compensation, and harmonic injections that detract the overall power quality of the typical distribution network. © 2014 AIP Publishing LLC.

Patient and practitioner compliance with silicone hydrogel and daily disposable lens replacement in the United States

Objective: The objectives of this study were to assess current recommendations for replacement frequency (RF) of silicone hydrogel (SH) and daily disposable (DD) lenses, to determine compliance with these recommendations, and to investigate the reasons given for noncompliance.

Methods: A package containing 20 patient surveys was sent to 309 eye care practitioners (ECPs) in the United States who had agreed to participate in the study. One thousand eight hundred fifty-nine completed surveys were received from 158 ECPs and 1,654 surveys were eligible for analysis. Questions related to patient demographics, lens type, lens wearing patterns, the ECP instructions for RF, and the actual patient reported RF. ECPs were asked to provide lens information and their recommendation for RF after the surveys had been completed and sealed in envelopes. All responses were anonymous.

Results: Sixty-six percent of patients were women and their mean age was 34 ± 12 years. Eighty-eight percent of lenses were worn for daily wear, 12.8 ± 3.2 hours a day, 6.2 ± 1.5 days a week. Lens type distribution was 16% DD, 45% 2 week (2W) SH, and 39% 1 month (1M) SH. ECP recommendations for RF varied according to the lens type; 1% of 1M (95% CI 0.2-1.7), 4% of DD (95% CI 2.1-7.2), and 18% of 2W (95% CI 15.1-20.7) patients were given instructions that did not conform to the manufacturers' recommended RF (MRRF). When considering only those patients who were given the correct instructions for RF, 38% were not compliant with the MRRF; noncompliance rates varied according to the lens type and were 12% for DD (95% CI 8.6-17.2), 28% for 1M (95% CI 24.9-32.1), and 52% for 2W (95% CI 47.8-55.8). The most frequent reasons for over wearing lenses were forgetting which day to replace lenses (51%) and to save money (26%). Fifty-three percent believed that a reminder system would aid compliance; the most popular methods being a cell phone reminder or text message (29%) and a nominated day each week or month (26%). Discussions between the ECPs and the patients were more extensive for patients who were compliant with the MRRF.

Conclusions: ECPs recommended RFs more frequently with DD and 1M SH lenses than with 2W SH lenses, consistent with manufacturers' recommendations. Patients were less compliant with RF than ECPs for all lens types investigated. Patients were most compliant with RF when wearing DD lenses and least compliant when wearing 2W SH lenses. Better communication facilitated greater compliance with RF. More than half of those not replacing lenses, when recommended, reported that this was because they forgot which day to replace their lenses.

Patient and practitioner compliance with silicone hydrogel and daily disposable lens replacement in Canada

Purpose: To assess current recommendations by optometrists for replacement frequency (RF) of silicone hydrogels (SH) and daily disposable (DD) contact lenses in Canada, determine rates of non-compliance with recommendations by both the optometrist and patient, and investigate reasons for non-compliance.

Methods: Survey packages were sent to optometrists in Canada who had agreed to participate. Patients completed survey questions regarding demographics and contact lens wearing patterns, including recommended and actual contact lens RF. Optometrists were asked to provide lens information and their recommendation for RF. Fifty-eight optometrists returned 654 surveys, of which 578 were eligible for analysis.

Results: Seventy percent of patients were female with a median age of 32 years. Lens type distribution was 18% DD, 35% two-week SH, and 47% one-month SH. Six percent were worn for extended wear. Daily wear median wearing time was 12 hours/day, a median of five days/week for DD, seven days/week for SH (two-week and one-month). Optometrists’ recommendations were non-compliant with the manufacturers’ recommended RF for 6% of DD, 35% of two week, and 2% of one-month patients. Patients were non-compliant with recommendations from both the manufacturer and optometrist for 12% of DD, 43% of two-week, and 31% of one-month lens wearers. The most common reason for non-compliance was forgetting which day to replace lenses. Fifty-six percent thought a reminder system would help with compliance. A higher proportion of compliant patients followed the RF because of confidence in their optometrist.

Conclusions: Optometrists generally recommended RFs consistent with manufacturers’ recommendations for DD and one-month SH lenses but often recommended longer intervals for two-week SH lenses. Patients were most compliant when wearing DD lenses and least compliant when wearing two-week SH lenses. Communication between the patient and optometrists concerning the risks of non-compliance, or initiating a reminder system might improve compliance.

Exploring a recently developed census population model of the diversity of the sixteen psychological types in Australia

It is important for practitioners to know about the distribution of the sixteen psychological types in the country in which they operate. For instance: Are more females with Feeling preferences found in particular occupational categories? Can you make valid distinctions on the basis of the types found in sales workers compared with other categories? What are the differences in the Australian distribution of psychological types compared with the UK and USA? Participants in this workshop will be encouraged to make connections between their own experience of the diversity of types and a recently developed Australian Census Population Type Table which for the first time approaches a national probability sample. We will explore the patterns of type distribution in Australia, and compare the data with national population Type Tables developed in the UK and the USA.

Voltage stability analysis with optimum size and location based synchronous machine DG

Power loss of a distribution system can be reduced significantly by using optimum size and location of distributed generation (DG). Proper allocation of DG with appropriate size maximizes overall system efficiency. Moreover it improves the reliability and voltage profile of the distribution system. In this paper, IEEE 123 node test feeder has been considered to determine the optimum size and location of a synchronous machine based DG for loss reduction of the system. This paper also investigates the steady-state and dynamic voltage profile of that three phase unbalance distribution network in presence of DG with optimum size. This analysis shows that optimum size of DG at proper location minimizes the power loss as well as improves the dynamic voltage profile of the distribution system.

Fire and climatic extremes shape mammal distributions in a fire-prone landscape

Aim: Extreme climatic events and large wildfires are predicted to increase as the world's climate warms. Understanding how they shape species' distributions will be critical for conserving biodiversity. We used a 7-year dataset of mammals collected during and after south-east Australia's Millennium Drought to assess the roles of fire history, climatic extremes and their interactions in shaping mammal distributions. Location: Grampians National Park, south-eastern Australia.

Methods: We surveyed mammals at 36 sites along a ~50-year post-fire chronosequence in each of the 7 years. We modelled ten mammal species in relation to fire history, productivity and recent rainfall. Next, we examined the consistency of species' fire response curves across each of three climatic phases relating to the Millennium Drought. Finally, we identified the optimal distribution of fire ages for small and medium-sized mammal conservation in each of the three climatic phases.

Results: The majority of species were influenced by fire history, and all native species were negatively associated with recently burned vegetation. Seven of ten species responded positively to the end of the Millennium Drought, but six of these declined quickly thereafter. Species' responses to fire history differed depending on the climatic conditions. However, the optimal distribution of fire-age classes consistently emphasized the importance of older age classes, regardless of climatic phase. This distribution is in stark contrast to the current distribution of fire ages across the study region.

Main conclusions: Mammals in the study region face an uncertain future. The negative impact of drought, the short-lived nature of post-drought recovery and, now, the possibility of a new drought beginning forewarn of further declines. The stark contrast between the optimal and current fire-age distributions means that reducing the incidence of further fires is critical to enhance the capacity of native mammal communities to weather an increasingly turbulent climate.

π-Selective stationary phases: (I) Influence of the spacer chain length of phenyl type phases on the aromatic and methylene selectivity of aromatic compounds in reversed phase high performance liquid chromatography

Phenyl type stationary phases of increasing spacer chain length (phenyl, methyl phenyl, ethyl phenyl, propyl phenyl and butyl phenyl, with 0–4 carbon atoms in the spacer chain, respectively) were synthesised and packed in house to determine the impact that the spacer chain length has on the retention process. Two trends in the aromatic selectivity, q_aromatic, were observed, depending on whether the number of carbon atoms in the spacer chain is even or odd. Linear log k′ vs ϕ plots were obtained for each stationary phase and the S coefficient was determined from the gradient of these plots. For the phenyl type phases, the S vs n_c plots of the retention factors of linear polycyclic aromatic hydrocarbons vs the number of rings exhibit a distinct discontinuity that between 3 and 4 rings, which increases with increasing spacer chain length for even phases but decreases for odd phases. Accordingly, we suggest that the retention factors depend differently on the number of carbon atoms in the spacer chain depending on whether this number is even or odd and that this effect is caused by different orientations of the aromatic ring relative to the silica surface.

A new approach for wind and solar type DG placement in power distribution networks to enhance systems stability

This paper proposes a distributed generator (DG) placement methodology based on newly defined term reactive power loadability. The effectiveness of the proposed planning is carried out over a distribution test system representative of the Kumamoto area in Japan. Firstly, this paper provides simulation results showing the sensitivity of the location of renewable energy based DG on voltage profile and stability of the system. Then, a suitable location is identified for two principal types DG, i. e., wind and solar, separately to enhance the stability margin of the system. The analysis shows that the proposed approach can reduce the power loss of the system, which in turn, reduces the size of compensating devices.

Impact of SCIG and DFIG type wind turbine on the stability of distribution networks: Static and dynamic aspects

This paper presents potential barriers to integrate the squirrel cage induction generator (SCIG) and doubly fed induction generator (DFIG) type wind turbine in distribution networks. The analysis is carried out over a 16 bus distribution test system. Both static and dynamic analyses are performed to see the impact of two different generators on the distribution system. The simulation results show that both SCIG and DFIG type wind turbines have significant impact on the static voltage stability, power loss, and dynamic behavior of the system, which should be taken into account to improve systems performance before integrating wind generation in existing distribution networks.

A control methodology for DFIG type wind turbines connected to distribution networks

This paper proposes a decentralised controller design for doubly-fed induction generators (DFIGs) to enhance dynamic performance of distribution networks. The change in the output power due to the variable nature of wind is considered as an uncertain term in the design algorithm. In addition, the interconnection effect of the other subsystems are considered in the design process. The H norm of the uncertain system is found out and simultaneous output-feedback linear controllers are designed based controller is verified on a 16 bus distribution test system for severe disturbances. Simulation results indicate that the designed controller is robust against uncertainties in operating conditions

Size distribution and volume fraction of T1 phase precipitates from TEM images: Direct measurements and related correction

Transmission Electron Microscopy (TEM) can be used to measure the size distribution and volume fraction of fine scale precipitates in metallic systems. However, such measurements suffer from a number of artefacts that need to be accounted for, related to the finite thickness of the TEM foil and to the projected observation in two dimensions of the microstructure. We present a correction procedure to describe the 3D distribution of disc-like particles and apply this method to the plate-like T1 precipitates in an Al-Li-Cu alloy in two ageing conditions showing different particle morphologies. The precipitates were imaged in a High-Angular Annular Dark Field Microscope (HAADF-STEM). The corrected size distribution is further used to determine the precipitate volume fraction. Atom probe tomography (APT) is finally utilised as an alternative way to measure the precipitate volume fraction and test the validity of the electron microscopy results.

Distribution of carbon nanotubes in fresh ordinary Portland cement pastes: understanding from a two-phase perspective

Significant research advances have been made in the field of carbon nanotube (CNT) reinforced ordinary Portland cement (OPC) paste composites in recent years. However, the distribution of CNTs in fresh OPC paste is yet to be fully researched and quantified, thereby creating a technical barrier to CNT utilization in concrete construction. In this study, fresh OPC paste was treated as a two-phase material containing solid particles (cement grains) and liquid solutions (pore solutions). A centrifugation-based technique was proposed to separate these two phases and the presence of CNTs in each phase was quantified. UV-Vis spectrometry showed that the degree of dispersion can achieve above 90 wt% using polycarboxylate superplasticizer. The results suggested an upper limit of 0.26 wt% for CNT addition into water before mixing with OPC, and the dispersion was found to be stable for at least 4 hours. Based on scanning electron imaging, the adsorption phenomenon of CNTs on OPC grains with size less than 4 μm was discovered. Energy-dispersive X-ray spectroscopy indicated these adsorptive particles have lower Ca to Si ratio. It was observed that about 0.5 mg of CNTs per gram of OPC grains was adsorbed in solid OPC grains in typical fresh OPC pastes. On the basis of these results, a conceptual model was proposed for the distribution of CNTs in fresh OPC paste where about 33 wt% of the CNTs stay in pore solution and 65 wt% of CNTs are adsorbed on OPC grains.