The architectural edifice and the phantoms of history

Starting with the literal and physical role of the "ground," this article attempts to bring this "ground" into a discursive arena. In particular, the author is thinking about the period at the end of a war, the period in between destruction and reconstruction, exemplified in some classic postwar films in which the architecture of the city is in a state of ruin—deformed, eroded, and dark—but there is no further destruction. The article calls this period "a gap of history" and its investigation is set against a claim that architecture is a reconstructive practice, that it is enlightening and aspiring. History, on the other hand, is captured by scenes of the battlefield and dominated by a narrative of war and destruction. The article makes reference to the real and fantasy desire for destruction (war and history) and reconstruction (architecture), and how through the connecting plane of the ground architecture is entangled in war and history of destruction as it figures in reconstruction. Architecture is contingent on history as discursive—history that is not unified, fixed, or evolutionary but rather contested and rewritten within a conflictual battlefield.

Refractive index tomography of turbid media by bifocal optical coherence refractometry

We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on the measurement of the optical pathlength difference between two foci simultaneously present in a medium of interest. We describe a new method to axially shift the bifocal optical pathlength that avoids the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, including video clips, which demonstrate refractive index tomography of a range of turbid liquid phantoms, as well as of human skin in vivo.

He's not there: velvet goldmine and the spectral Bowie persona

In broad terms, this paper examines what I call Todd Haynes' 'hauntological' approach to the celebrity biopic. More specifically, it focuses on Velvet Goldmine (1998) and argues that Haynes represents Bowie's Ziggy Stardust persona as a series of phantoms in the Derridean sense. That is, figures that are both absent and present, material and immaterial— figures that affirm that no identity can ever be quite complete since the markers of identity are always enmeshed in a network of differences that can be continually re-coded. Haynes' original script contained several Bowie songs, which he was forced to replace when Bowie refused to give him permission to use the music (Bowie claimed he intended to make his own film about his Ziggy Stardust period). Undeterred, Haynes produced a movie that made no direct reference to Bowie by name, yet recoded Bowie's multiple personas and characters in a parallel cinematic world. Haynes' film invites the spectator to re-think Identity in terms of 'contamination' and 'inauthenticity'. He also establishes a genealogical connection between Oscar Wilde (one of the film's many spectres) and Bowie by making several allusions to the parallels between 19th century aestheticism and Glam Rock. In short, I argue that Haynes' film facilitates a critique of the idea that Bowie's shifting identity is merely a question of aesthetic choice, or an expression of any kind of cultural logic. Rather, I argue that the figure of the Derridean phantom offers a new way to read Velvet Goldmine, and to identify the cultural work performed by Bowie's Ziggy Stardust persona.

Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents

BACKGROUND: Cardiovascular diseases are the most prevalent cause of morbidity and mortality affecting millions of people globally. The most effective way to counter cardiovascular complications is early diagnosis and the safest non-invasive diagnostic approach is magnetic resonance imaging (MRI). In this study, superparamagnetic ferrite nanoparticles doped with zinc, exhibiting highly enhanced saturation magnetization and T2 and computed tomography (CT) contrast were synthesized. These nanoparticles have been strategically engineered using bovine lactoferrin (Lf), polyethylene glycol (PEG), and heat shock protein (Hsp)-70 antibody specifically targeting atherosclerosis with potential therapeutic value. The nanocomplexes were further validated in vitro to assess their cytotoxicity, internalization efficiency, effects on cellular proliferation and were assessed for MRI as well as X-ray CT in ex vivo Psammomys obesus rat model.

RESULTS: Optimized zinc doped ferrite nanoparticles (Zn0.4Fe2.6O4) with enhanced value of maximum saturation magnetization value on 108.4 emu/g and an average diameter of 24 ± 2 nm were successfully synthesized. Successfully incorporation with bovine lactoferrin, PEG and Hsp-70 (70 kDa) antibody led to synthesis of spherical nanocomplexes (size 224.8 nm, PDI 0.398). A significantly higher enhancement in T2 (p < 0.05, 1.22-fold) and slightly higher T1 (1.09-fold) and CT (1.08-fold) contrast compared to commercial ferrite nanoparticles was observed. The nanocomplexes exhibited effective cellular internalization within 2 h in both THP-1 and Jurkat cells. MRI scans of contrast agent injected animal revealed significant arterial narrowing and a significantly higher T2 (p < 0.05, 1.71-fold) contrast in adult animals when compared to juvenile and control animals. The excised heart and aorta agar phantoms exhibited weak MRI contrast enhancement in juvenile animal but significant contrast enhancement in adult animal specifically at the aortic arch, descending thoracic aorta and iliac bifurcation region with X-ray CT scan. Histological investigation of the contrast agent injected aorta and heart confirmed site target-specific accumulation at the atherosclerotic aortic arch and descending thoracic aorta of the adult animal with severely damaged intima full of ruptured microatheromas.

CONCLUSION: Overall, the study demonstrates the strategic development of nanocomplex based bimodal MRI and CT contrast agents and its validation on Psammomys obesus for atherosclerosis diagnostics.