A particle swarm based hybrid system for imbalances medical data sampling

Background
Medical and biological data are commonly with small sample size, missing values, and most importantly, imbalanced class distribution. In this study we propose a particle swarm based hybrid system for remedying the class imbalance problem in medical and biological data mining. This hybrid system combines the particle swarm optimization (PSO) algorithm with multiple classifiers and evaluation metrics for evaluation fusion. Samples from the majority class are ranked using multiple objectives according to their merit in compensating the class imbalance, and then combined with the minority class to form a balanced dataset.

Results
One important finding of this study is that different classifiers and metrics often provide different evaluation results. Nevertheless, the proposed hybrid system demonstrates consistent improvements over several alternative methods with three different metrics. The sampling results also demonstrate good generalization on different types of classification algorithms, indicating the advantage of information fusion applied in the hybrid system.

Conclusion
The experimental results demonstrate that unlike many currently available methods which often perform unevenly with different datasets the proposed hybrid system has a better generalization property which alleviates the method-data dependency problem. From the biological perspective, the system provides indication for further investigation of the highly ranked samples, which may result in the discovery of new conditions or disease subtypes.

An accelerated particle swarm optimization based levenberg marquardt back propagation algorithm

The Levenberg Marquardt (LM) algorithm is one of the most effective algorithms in speeding up the convergence rate of the Artificial Neural Networks (ANN) with Multilayer Perceptron (MLP) architectures. However, the LM algorithm suffers the problem of local minimum entrapment. Therefore, we introduce several improvements to the Levenberg Marquardt algorithm by training the ANNs with meta-heuristic nature inspired algorithm. This paper proposes a hybrid technique Accelerated Particle Swarm Optimization using Levenberg Marquardt (APSO_LM) to achieve faster convergence rate and to avoid local minima problem. These techniques are chosen since they provide faster training for solving pattern recognition problems using the numerical optimization technique.The performances of the proposed algorithm is evaluated using some bench mark of classification’s datasets. The results are compared with Artificial Bee Colony (ABC) Algorithm using Back Propagation Neural Network (BPNN) algorithm and other hybrid variants. Based on the experimental result, the proposed algorithms APSO_LM successfully demonstrated better performance as compared to other existing algorithms in terms of convergence speed and Mean Squared Error (MSE) by introducing the error and accuracy in network convergence.

Multi-layer attribute selection and classification algorithm for the diagnosis of cardiac autonomic neuropathy based on HRV attributes

Cardiac autonomic neuropathy (CAN) poses an important clinical problem, which often remains undetected due difficulty of conducting the current tests and their lack of sensitivity. CAN has been associated with growth in the risk of unexpected death in cardiac patients with diabetes mellitus. Heart rate variability (HRV) attributes have been actively investigated, since they are important for diagnostics in diabetes, Parkinson's disease, cardiac and renal disease. Due to the adverse effects of CAN it is important to obtain a robust and highly accurate diagnostic tool for identification of early CAN, when treatment has the best outcome. Use of HRV attributes to enhance the effectiveness of diagnosis of CAN progression may provide such a tool. In the present paper we propose a new machine learning algorithm, the Multi-Layer Attribute Selection and Classification (MLASC), for the diagnosis of CAN progression based on HRV attributes. It incorporates our new automated attribute selection procedure, Double Wrapper Subset Evaluator with Particle Swarm Optimization (DWSE-PSO). We present the results of experiments, which compare MLASC with other simpler versions and counterpart methods. The experiments used our large and well-known diabetes complications database. The results of experiments demonstrate that MLASC has significantly outperformed other simpler techniques.