Cognitive remission: a novel objective for the treatment of major depression?

BACKGROUND: Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. Furthermore, cognitive dysfunction is a frequent residual manifestation in depression and may persist during the remitted phase. Cognitive deficits may also impede functional recovery, including workforce performance, in patients with MDD. The overarching aims of this opinion article are to critically evaluate the effects of available antidepressants as well as novel therapeutic targets on neurocognitive dysfunction in MDD.

DISCUSSION: Conventional antidepressant drugs mitigate cognitive dysfunction in some people with MDD. However, a significant proportion of MDD patients continue to experience significant cognitive impairment. Two multicenter randomized controlled trials (RCTs) reported that vortioxetine, a multimodal antidepressant, has significant precognitive effects in MDD unrelated to mood improvement. Lisdexamfetamine dimesylate was shown to alleviate executive dysfunction in an RCT of adults after full or partial remission of MDD. Preliminary evidence also indicates that erythropoietin may alleviate cognitive dysfunction in MDD. Several other novel agents may be repurposed as cognitive enhancers for MDD treatment, including minocycline, insulin, antidiabetic agents, angiotensin-converting enzyme inhibitors, S-adenosyl methionine, acetyl-L-carnitine, alpha lipoic acid, omega-3 fatty acids, melatonin, modafinil, galantamine, scopolamine, N-acetylcysteine, curcumin, statins, and coenzyme Q10. The management of cognitive dysfunction remains an unmet need in the treatment of MDD. However, it is hoped that the development of novel therapeutic targets will contribute to 'cognitive remission', which may aid functional recovery in MDD.

Decisionmaking in a glass house : mass media, public opinion, and American and European foreign policy in the 21st century

"Decisionmaking in a Glass House: Mass Media, Public Opinion, and American and European Foreign Policy in the 21st Century" edited by Brigitte L. Nacos, Robert Y. Shapiro and Pierangelo Isernia is reviewed.

Australian public opinion on citizenship and transnational ties in Asia

At a time of increasing national security, this article explores the ways in which migrant communities from Asia feel a sense of attachment to exclusive and inclusive forms of national citizenship while at the same time maintaining transnational links. Drawing on data from the Australian Survey of Social Attitudes (2003), the study utilises a quantitative methodology. The strength of this methodological approach lies in its capacity to describe the importance of different categories in shaping public opinion on citizenship and transnational connections in Asia. This study compares the views of Asian-Australians with the rest of the Australian population.

Law-and-order politics, public-opinion polls, and the media

Over the past two decades, considerable political rhetoric has focused on the need to get tough on crime. Justification for this hard-line approach has been the public's apparent concem about rising crime rates and its increasing dissatisfaction with criminal sentencing. In this paper, we consider characteristics both of the measurement of public opinion and of the influences upon public opinion that may contribute to the depiction of a fearful, punitive community. In particular, we identify sources of bias in the methods and contexts of opinion-polling that promote a distorted representation of the discrepancy between community expectations of sentencing and the practices of the judiciary. We argue that the practices of pollsters, politicians, and media combine to create a self-sustaining obstacle to considered community discussion of crime and criminal sentencing.

Public opinion and ethics

The article reports on the complicated relationship between public opinion and ethics and discusses how large a role, if any, public opinion should play in issues related to health care, such as euthanasia. In the article the author offers her opinions on democracy and on the role that public opinion plays in solving ethical issues related to health care.

How Differences of Opinion Influence Students’ Capacity to Think Geographically

Currently, the Australian Government is working towards the development and implementation of a national geography curriculum for Australian Schools. A common response to the question of what geography education is based upon is ‘maps’ (Sorenson, 2009). Geography teachers, curriculum designers and educational researchers alike face the battle of broadening the perception of geography education beyond this view (Sorenson, 2009; Maude, 2009; McInerney, Berg, Hutchinson, Maude & Sorenson, 2009). The Shape of the National Curriculum for Geography (Australian Curriculum and Reporting Authority 2011, p8) states that the new curriculum will “develop students’ broader ability to think critically about contemporary events”. This new direction demonstrates a focus in on students’ capacity to ‘think geographically’ (Jackson 2006). This study engages with this new curriculum direction and explores the influence of an approach to group learning pedagogy based around students’ differences of opinion on students’ capacity to think geographically. A sample of 43 Year 9 Geography students participated in a two week learning sequence investigating the impacts of large scale earthquakes.
This paper communicates the findings from a comparative case study analysis of two student group conversations of different group types. According to the results of this study, organising students into groups around their differences of opinion encourages students to engage in and sustain higher levels of geographical thinking.

Occupational therapy with people with depression: using nominal group technique to collate clinician opinion

AIMS: This aim of this study was to obtain a consensus from clinicians regarding occupational therapy for people with depression, for the assessments and practices they use that are not currently supported by research evidence directly related to functional performance. The study also aimed to discover how many of these assessments and practices were currently supported by research evidence.

METHODS: Following a previously reported systematic review of assessments and practices used in occupational therapy for people with depression, a modified nominal group technique was used to discover which assessments and practices occupational therapists currently utilize. Three online surveys gathered initial data on therapeutic options (survey 1), which were then ranked (survey 2) and re-ranked (survey 3) to gain the final consensus. Twelve therapists completed the first survey, whilst 10 clinicians completed both the second and third surveys.

MAJOR FINDINGS: Only 30% of the assessments and practices identified by the clinicians were supported by research evidence. A consensus was obtained on a total of 35 other assessments and interventions. These included both occupational-therapy-specific and generic assessments and interventions. Principle conclusion. Very few of the assessments and interventions identified were supported by research evidence directly related to functional performance. While a large number of options were generated, the majority of these were not occupational therapy specific.

Exploring judicial opinion on the relationship between anabolic-androgenic steroid use and violent offending

Research suggests that there is a link between the use of anabolic-androgenic steroids (AAS) and violence, though this link may be moderated by other substance use such as alcohol. Violent acts in the nighttime economy in recent times has led to governments adopting a law enforcement approach. This study sought to investigate whether the judicial system considers that there is a link between AAS use and violence. Sentencing decisions in Victoria, Australia, were identified using three publically available case law databases. Of the six cases identified, three cases had some mention of a potential link between AAS use and violent offending; however, it appears that evidence of AAS use had neither an aggravating nor mitigating effect on sentencing. In all six cases, a history of other substance use had more of an impacting upon sentencing. Harm reduction approaches should be adopted to reduce violence related to any substance use, including AAS.

Public opinion, social cohesion and the politics of immigration in South Korea

This article analyses public opinion in order to explore the politics of immigration in South Korea. It argues that there are divergent views about immigration and the obligations of the host society to accommodate migrants. Younger, better-educated citizens are representative of a majority that has a generally positive view of immigrants and immigration. A sizeable minority of older and less well-educated citizens, however, is warier of immigration and its effects on South Korean society. Men were more likely than women to have a positive view of immigration, but the differences along gender lines were small. The article also finds that attitudes towards immigration depend to a significant degree on how migrants are described. It thereby highlights the possibility that South Korea’s leaders could use immigration for political gain while also seeking to attract new migrants in order to resolve the country’s economic and demographic problems.

Cycles in public opinion and the dynamics of stable party systems

We study a dynamic model of elections where many parties may enter or exit political competition. At each election a new political leadership arrives for each party. The leadership cannot choose the party's platform (ideological identities are fixed) but must decide whether or not to contest the election. Contesting elections is costly and this cost is higher if the party has recently been inactive. The distribution of voters' ideal policies, or public opinion, changes over time via a Markov process with a state independent persistence parameter. We characterise stable party systems where the set of contestants is invariant to the recent most observed opinion. We show that stable party systems exist only when public opinion is sufficiently volatile, while highly persistent moods lead to instability and change in the party system whenever public opinion changes.