Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus

It has been reported previously that leptin may be involved in nicotine's ability to reduce body weight. Our aim was to investigate whether the anorexic action of nicotine is related to the actions of leptin by utilizing lean leptin-sensitive and obese leptin-resistant Psammomys obesus. Lean and obese P. obesus were assigned to receive nicotine sulphate at 6, 9 or 12 mg/day or saline (control) for 9 days (n = 6-10 in each group), administered using mini-osmotic pumps. Food intake, body weight, plasma leptin concentrations, plasma insulin and blood glucose were measured at baseline and throughout the study period. Nicotine treatment reduced food intake by up to 40% in lean and obese P. obesus. Plasma leptin levels fell significantly only in lean nicotine-treated animals, whereas no changes were observed in obese nicotine-treated animals. However, both lean and obese nicotine-treated animals had similar reductions in body weight. Our results show that nicotine has dramatic effects on food intake and body weight, however, these changes appear to be independent of the leptin signalling pathway.

Some characteristics of early Australian PhD theses

The first PhDs in Australia were awarded in the late 1940s and 1950s. This paper reports on some research being conducted by the authors that involves reviewing early PhD theses from the Universities of Melbourne, Queensland and Sydney. The paper discusses some selected features of the candidates, fields of study and theses. Photographs and facsimiles from a selection of early theses illustrate some peculiarities of the time.

Disciplinary differences in Australian PhD theses 1987-2006 and the implications for future research capacity

The paper, which draws on data previously presented at the 2010 World Universities Forum in Davos, Switzerland (Evans & Macauley, 2010), presents and tabulates a variety of trends from the Database of Australian Doctorates, in particular, those relating to the ebb and flow of PhDs in particular selected ‘academic’ and ‘professional’ disciplines in Australia. The paper commences with an overview of the research methods and outcomes. Four academic disciplines (astronomy, chemistry, cultural studies and demography) and four professional disciplines (architecture and building, education, librarianship and nursing) are selected for analysis of their 1987–2006 PhD thesis records. These selections were made to reflect a range of academic and professional disciplines in Australia and to illustrate the changes that have occurred over the past two decades. The period 1987-2006 covers several major changes in Australian university education and PhD education.

Research capacity implications for government, universities and disciplines from research into Australian PhD theses and their graduates’ scholarly, professional and community impacts

The authors (with colleagues) have conducted research into Australian doctoral education for over a decade. Two recent projects have produced as part of their outcomes: a database coded by discipline of all Australian PhD theses (dissertations) from 1987–2006. This paper commences with an overview of this work in terms of its purposes, research methods and outcomes. It is contextualized in terms of the current Australian and international debates about the nature, substance and impact of doctoral education on nations, societies, communities and economies. The paper presents some analyses of trends in the 1987–2006 Australian PhD theses. The period 1987-2006 covers several major changes in university education in Australia from the impact of the establishment of the Unified National System in the early 1990s, through the implementation of the Research Training Scheme (RTS) from 2001, the deliberations and demise of the Research Quality Framework (RQF), the rise of Excellence in Research Australia (ERA), through to the review of research training and the research workforce in Australian universities by the House of Representatives. The paper presents and tabulates a variety of trends from the bibliometric and bibliographic data, in particular those relating to the ebb and flow of PhDs in particular disciplines. The implications for national, institutional and disciplinary planners and policymakers with interests in the development and sustainability of research capacity are discussed.

Classifying Australian PhD theses : linking research and library practices

This paper draws on the findings from, and the methods and approach used, in the provision of a database of Australian PhD thesis records for the period 1987 to 2006, coded by Research Fields, Courses and Disciplines (RFCD) fields of study. The project was funded by the Research Excellence Branch of the Australian Research Council. Importantly, the project was not merely the creation of yet another database but constitutes a valuable research resource in its own right. It provides an alternative source of data about research training with a focus on research output and research capacity building rather than input as does data on enrolment. The database is significant as it can be used to track knowledge production in Australia over a twenty year period and contains approximately 54,000 bibliographic records. The database of Australian PhDs has been constructed from downloaded bibliographic records from Libraries Australia. Recommendations for practice relate to university libraries, doctoral candidates, and the coded database. We suggest that libraries are more consistent with cataloguing procedures, including the thesis ‘publication’ date, and that they are more timely in uploading their thesis records to Libraries Australia or, alternatively, Australian Research Online. We also suggest that PhD candidates code their own theses using the new ANZSRC scheme (which replaced the RFCD classification in 2008), and also use clear and communicative thesis titles and thesis abstracts. With regard to the coded database, we suggest it becomes a requirement for universities to provide the ANZSRC coding of submitted theses

Classifying Australian PhD theses: linking research and library practices

This article draws on the findings from, and the methods and approach used in the provision of a database of Australian PhD thesis records for the period 1987 to 2006, coded by Research Fields, Courses and Disciplines (RFCD) fields of study. Importantly, the project was not merely the creation of yet another database but constitutes a valuable research resource in its own right. The database is significant as it can be used to track knowledge production in Australia over a twenty year period and contains approximately 54,000 bibliographic records. Recommendations for practice relate to university libraries, doctoral candidates, and the coded database.

Australian PhD theses in selected professional and academic disciplines 1987–2006 and the implications for future research capacity

This commences with an overview the research methods and outcomes. It is contextualised in terms of the current Australian and international debates about the nature, substance and impact of doctoral education on nations, societies, communities and economies. Four professional disciplines (architecture and building, education, librarianship and nursing) and four academic disciplines (astronomy, chemistry, cultural studies and demography) are selected for analysis of their 1987–2006 PhD thesis records. These selections were made to reflect a range of professional and academic disciplines in Australia and to illustrate the changes that have occurred over the past two decades. The period 1987-2006 covers several major changes in Australian university education and PhD education in particular.

A decade of MERGA theses

The MERGA website has a list of the titles of the last 10 years of Australasian mathematics education Masters and Doctoral theses, with linked abstracts. After a discussion about the socially-determined nature of document analysis, this paper reports the results of an interpretive document analysis of the web page and the pages of abstracts, with a focus on
(a) numbers of theses, by year and by institution;
(b) methodological approaches used;
(c) countries where data were collected; and
(d) theses topics. Begle’s (1979) framework of mathematics education domains is used to categorise 3 descriptors for each thesis.

A role for the DRD4 exon III VNTR in modifying the association between nicotine dependence and neuroticism

Introduction: Neurotic psychopathology has been extensively examined as a risk factor for nicotine dependence (ND). Genetic stratification may partially explain variability in risk estimates. Genetic variants that compromise dopaminergic neurotransmission may motivate exposure to dopamine-stimulating agents, including nicotine. The 7-repeat allele of a Variable Number Tandem Repeat (VNTR) polymorphism in DRD4 (and evolutionary derivatives 5, 6, and 8 repeats; 7R+) is associated with reduced dopamine receptor function. The purpose of this study was to examine association between both smoking initiation (SI) and progression to ND by young adulthood and (a) history of neuroticism during adolescence, (b) DRD4 7R+, and (c) interaction between neuroticism and DRD4 7R+.

Methods: Participants were drawn from the Victorian Adolescent Health Cohort Study, a longitudinal study of the health and well-being of young Australians across 8 waves (14–24 years). Neuroticism was measured at Waves 3 and 6 (mean 15.9 and 17.4 years). SI was defined as any smoking at any wave. ND was measured at Wave 8 (mean 24.1 years). Genotype data for the DRD4 VNTR were available for 839 participants.

Results: While adolescent neuroticism was associated with SI, evidence for association with progression to ND was weak. However, there was evidence of interaction between neuroticism and DRD4 7R+: The odds of progression to ND among those with a history of neuroticism were more than 3.5-fold higher among 7R+ carriers.

Conclusions: Without considering stratification by 7R+, the association between progression to ND and neuroticism would have been assumed barely significant. However, among those carrying DRD4 7R+, risk of progression was considerably intensified.