Neural signal analysis by landmark-based spectral clustering with estimated number of clusters

Spike sorting plays an important role in analysing electrophysiological data and understanding neural functions. Developing spike sorting methods that are highly accurate and computationally inexpensive is always a challenge in the biomedical engineering practice. This paper proposes an automatic unsupervised spike sorting method using the landmark-based spectral clustering (LSC) method in connection with features extracted by the locality preserving projection (LPP) technique. Gap statistics is employed to evaluate the number of clusters before the LSC can be performed. Experimental results show that LPP spike features are more discriminative than those of the popular wavelet transformation (WT). Accordingly, the proposed method LPP-LSC demonstrates a significant dominance compared to the existing method that is the combination between WT feature extraction and the superparamagnetic clustering. LPP and LSC are both linear algorithms that help reduce computational burden and thus their combination can be applied into realtime spike analysis.

A miniature neural recording device

This paper presents a portable neural recording device for use with laboratory animals. It can detect and record neural signals from the cortical region of the brain during pre-clinical trials. The device utilizes simplified circuitry to perform signal detection, filtering, sampling, and storage. It includes analog and digital components each implemented on a separate small printed circuit board. The two printed circuit boards are then attached to one another to form the device. It is capable of uninterrupted operation for over 2 hours on a single coin battery. A bench-testing of the device was performed with pre-recorded neural signal which then injected to the input of the device to give validation of efficient operation of the device. Its amplification and filtration features have been analyzed. An overall 56 dB amplification and filtration in the frequency range of 300 Hz to 4 KHz was achieved. Sampling and storage at a reduced power and computational load is demonstrated with uninterrupted storage of the neural signal. A comparison of the input and reconstructed neural signals shows minimal variation error.

The neuronal noradrenaline transporter, anxiety and cardiovascular disease

Panic disorder can serve as a clinical model for testing whether mental stress can cause heart disease. Potential neural mechanisms of cardiac risk are the sympathetic activation during panic attacks, continuing release of adrenaline as a co-transmitter in the cardiac sympathetic nerves, and impairment of noradrenaline neuronal reuptake, augmenting sympathetic neural respnses.

The phenotype of impaired neuronal reuptake of noradrenaline: an epigenetic mechanism? We suspect that this phenotype, in sensitizing people to heart symptom development, is a cause of panic disorder, and by magnifying the sympathetic neural signal in the heart, underlies increased cardiac risk. No loss of function mutations of the coding region of the norepinephrine transporter (NET) are evident, but we do detect hypermethylation of CpG islands in the NET gene promoter region. Chromatin immunoprecipitation methodology demonstrates binding of the inhibitory transcription factor, MeCP2, to promoter region DNA in panic disorder patients.

Cardiovascular illnesses co-morbid with panic disorder. Panic disorder commonly coexists with essential hypertension and the postural tachycardia syndrome. In both of these cardiovascular disorders the impaired neuronal noradrenaline reuptake phenotype is also present and, as with panic disorder, is associated with NET gene promoter region DNA hypermethylation. An epigenetic ‘co-morbidity’ perhaps underlies the clinical concordance.

Brain neurotransmitters. Using internal jugular venous sampling, in the absence of a panic attack we find normal norepinephrine turnover, but based on measurements of the overflow of the serotonin metabolite, 5HIAA, a marked increase (six to sevenfold) in brain serotonin turnover in patients with panic disorder. This appears to represent the underlying neurotransmitter substrate for the disorder. Whether this brain serotonergic activation is a prime mover, or consequential on other primary causes of panic disorder, including cardiac sensitization by faulty neuronal noradrenaline reuptake leading to cardiac symptoms and the enhanced vigilance which accompanies them, is unclear at present.

Neuron’s spikes noise level classification using hidden markov models

Considering that the uncertainty noise produced the decline in the quality of collected neural signal, this paper proposes a signal quality assessment method for neural signal. The method makes an automated measure to detect the noise levels in neural signal. Hidden Markov Models were used to build a classification model that classifies the neural spikes based on the noise level associated with the signal. This neural quality assessment measure will help doctors and researchers to focus on the patterns in the signal that have high signal to noise ratio and carry more information.

Prosthetic motor imaginary task classification using single channel of electroencephalography

Brain Computer Interface (BCI) is playing a very important role in human machine communications. Recent communication systems depend on the brain signals for communication. In these systems, users clearly manipulate their brain activity rather than using motor movements in order to generate signals that could be used to give commands and control any communication devices, robots or computers. In this paper, the aim was to estimate the performance of a brain computer interface (BCI) system by detecting the prosthetic motor imaginary tasks by using only a single channel of electroencephalography (EEG). The participant is asked to imagine moving his arm up or down and our system detects the movement based on the participant brain signal. Some features are extracted from the brain signal using Mel-Frequency Cepstrum Coefficient and based on these feature a Hidden Markov model is used to help in knowing if the participant imagined moving up or down. The major advantage in our method is that only one channel is needed to take the decision. Moreover, the method is online which means that it can give the decision as soon as the signal is given to the system. Hundred signals were used for testing, on average 89 % of the up down prosthetic motor imaginary tasks were detected correctly. This method can be used in many different applications such as: moving artificial prosthetic limbs and wheelchairs due to it's high speed and accuracy.

Optimal design of traffic signal controller using neural networks and fuzzy logic systems

This paper aims at optimally adjusting a set of green times for traffic lights in a single intersection with the purpose of minimizing travel delay time and traffic congestion. Neural network (NN) and fuzzy logic system (FLS) are two methods applied to develop intelligent traffic timing controller. For this purpose, an intersection is considered and simulated as an intelligent agent that learns how to set green times in each cycle based on the traffic information. The training approach and data for both these learning methods are similar. Both methods use genetic algorithm to tune their parameters during learning. Finally, The performance of the two intelligent learning methods is compared with the performance of simple fixed-time method. Simulation results indicate that both intelligent methods significantly reduce the total delay in the network compared to the fixed-time method.

Design of distributed adaptive neural traffic signal timing controller by cuckoo search optimization

This paper focuses on designing an adaptive controller for controlling traffic signal timing. Urban traffic is an inevitable part in modern cities and traffic signal controllers are effective tools to control it. In this regard, this paper proposes a distributed neural network (NN) controller for traffic signal timing. This controller applies cuckoo search (CS) optimization methods to find the optimal parameters in design of an adaptive traffic signal timing control system. The evaluation of the performance of the designed controller is done in a multi-intersection traffic network. The developed controller shows a promising improvement in reducing travel delay time compared to traditional fixed-time control systems.

Eccentricity and hardness control in cold rolling mills with a dynamically constructed neural controller

The main objective of a steel strip rolling process is to produce high quality steel at a desired thickness.  Thickness reduction is the result of the speed difference between the incoming and the outgoing steel strip and the application of the large normal forces via the backup and the work rolls.  Gauge control of a cold rolled steel strip is achieved using the gaugemeter principle that works adequately for the input gauge changes and the strip hardness changes.  However, the compensation of some factors is problematic, for example, eccentricity of the backup rolls.  This cyclic eccentricity effect causes a gauge deviation, but more importantly, a signal is passed to the gap position control so to increase the eccentricity deviation.  Consequently, the required high product tolerances are severely limited by the presence of the roll eccentricity effects.
In this paper a direct model reference adaptive control (MRAC) scheme with dynamically constructed neural controller was used.  The aim here is to find the simplest controller structure capable of achieving an optimal performance.  The stability of the adaptive neural control scheme (i.e. the requirement of persistency of excitation and bounded learning rates) is addressed by using as the inputs to the reference model the plant's state variables.  In such a case, excitation is due to actual plant signals (states) affected by plant disturbances and noise.  In addition, a reference model in the form of a filter with a desired transfer function using Modulus Optimum design was used to ensure variance in the desired dynamic characteristics of the system.  The gradually decreasing learning rate employed by the neural controller in this paper is aimed at eliminating controller instability resulting from over-aggressive control.  The moving target problem (i.e. the difficulty of global neural networks to perfrom several separate computational tasks in closed -loop control) is addressed by the localized architecture of the controller.  The above control scheme and learning algorithm offers a method for automatic discovery of an efficient controller.
The resulting neural controller produces an excellent disturbance rejection in both cases of eccentricity and hardness disturbances, reducing the gauge deviation due to eccentricity disturbance from 33.36% to 4.57% on average, and the gauge deviation due to hardness disturbance from 12.59% to 2.08%.

A neural networks learning algorithm for minor component analysis and its convergence analysis

The eigenvector associated with the smallest eigenvalue of the autocorrelation matrix of input signals is called minor component. Minor component analysis (MCA) is a statistical approach for extracting minor component from input signals and has been applied in many fields of signal processing and data analysis. In this letter, we propose a neural networks learning algorithm for estimating adaptively minor component from input signals. Dynamics of the proposed algorithm are analyzed via a deterministic discrete time (DDT) method. Some sufficient conditions are obtained to guarantee convergence of the proposed algorithm.

Parasites affect song complexity and neural development in a songbird

There is now considerable evidence that female choice drives the evolution of song complexity in many songbird species. However, the underlying basis for such choice remains controversial. The developmental stress hypothesis suggests that early developmental conditions can mediate adult song complexity by perturbing investment in the underlying brain nuclei during their initial growth. Here, we show that adult male canaries (Serinus canaria), infected with malaria (Plasmodium relictum) as juveniles, develop simpler songs as adults compared to uninfected individuals, and exhibit reduced development of the high vocal centre (HVC) song nucleus in the brain. Our results show how developmental stress not only affects the expression of a sexually selected male trait, but also the structure of the underlying song control pathway in the brain, providing a direct link between brain and behaviour. This novel experimental evidence tests both proximate and ultimate reasons for the evolution of complex songs and supports the Hamilton–Zuk hypothesis of parasite-mediated sexual selection. Together, these results propose how developmental costs may help to explain the evolution of honest advertising in the complex songs of birds.

Text-dependent speaker recognition using the Fuzzy ARTMAP neural network

Speaker recognition is the process of automatically recognizing the speaker by analyzing individual information contained in the speech waves. In this paper, we discuss the development of an intelligent system for text-dependent speaker recognition. The system comprises two main modules, a wavelet-based signal-processing module for feature extraction of speech waves, and an artificial-neural-network-based classifier module to identify and categorize the speakers. Wavelet is used in de-noising and in compressing the speech signals. The wavelet family that we used is the Daubechies Wavelets. After extracting the necessary features from the speech waves, the features were then fed to a neural-network-based classifier to identify the speakers. We have implemented the Fuzzy ARTMAP (FAM) network in the classifier module to categorize the de-noised and compressed signals. The proposed intelligent learning system has been applied to a case study of text-dependent speaker recognition problem.

Text-dependent speaker recognition using wavelets and neural networks

An intelligent system for text-dependent speaker recognition is proposed in this paper. The system consists of a wavelet-based module as the feature extractor of speech signals and a neural-network-based module as the signal classifier. The Daubechies wavelet is employed to filter and compress the speech signals. The fuzzy ARTMAP (FAM) neural network is used to classify the processed signals. A series of experiments on text-dependent gender and speaker recognition are conducted to assess the effectiveness of the proposed system using a collection of vowel signals from 100 speakers. A variety of operating strategies for improving the FAM performance are examined and compared. The experimental results are analyzed and discussed.

A review on computational intelligence methods for controlling traffic signal timing

Urban traffic as one of the most important challenges in modern city life needs practically effective and efficient solutions. Artificial intelligence methods have gained popularity for optimal traffic light control. In this paper, a review of most important works in the field of controlling traffic signal timing, in particular studies focusing on Q-learning, neural network, and fuzzy logic system are presented. As per existing literature, the intelligent methods show a higher performance compared to traditional controlling methods. However, a study that compares the performance of different learning methods is not published yet. In this paper, the aforementioned computational intelligence methods and a fixed-time method are implemented to set signals times and minimize total delays for an isolated intersection. These methods are developed and compared on a same platform. The intersection is treated as an intelligent agent that learns to propose an appropriate green time for each phase. The appropriate green time for all the intelligent controllers are estimated based on the received traffic information. A comprehensive comparison is made between the performance of Q-learning, neural network, and fuzzy logic system controller for two different scenarios. The three intelligent learning controllers present close performances with multiple replication orders in two scenarios. On average Q-learning has 66%, neural network 71%, and fuzzy logic has 74% higher performance compared to the fixed-time controller.

EEG signal classification for BCI applications by wavelets and interval type-2 fuzzy logic systems

The nonlinear, noisy and outlier characteristics of electroencephalography (EEG) signals inspire the employment of fuzzy logic due to its power to handle uncertainty. This paper introduces an approach to classify motor imagery EEG signals using an interval type-2 fuzzy logic system (IT2FLS) in a combination with wavelet transformation. Wavelet coefficients are ranked based on the statistics of the receiver operating characteristic curve criterion. The most informative coefficients serve as inputs to the IT2FLS for the classification task. Two benchmark datasets, named Ia and Ib, downloaded from the brain-computer interface (BCI) competition II, are employed for the experiments. Classification performance is evaluated using accuracy, sensitivity, specificity and F-measure. Widely-used classifiers, including feedforward neural network, support vector machine, k-nearest neighbours, AdaBoost and adaptive neuro-fuzzy inference system, are also implemented for comparisons. The wavelet-IT2FLS method considerably dominates the comparable classifiers on both datasets, and outperforms the best performance on the Ia and Ib datasets reported in the BCI competition II by 1.40% and 2.27% respectively. The proposed approach yields great accuracy and requires low computational cost, which can be applied to a real-time BCI system for motor imagery data analysis.

Intelligent cuckoo search optimized traffic signal controllers for multi-intersection network

Traffic congestion in urban roads is one of the biggest challenges of 21 century. Despite a myriad of research work in the last two decades, optimization of traffic signals in network level is still an open research problem. This paper for the first time employs advanced cuckoo search optimization algorithm for optimally tuning parameters of intelligent controllers. Neural Network (NN) and Adaptive Neuro-Fuzzy Inference System (ANFIS) are two intelligent controllers implemented in this study. For the sake of comparison, we also implement Q-learning and fixed-time controllers as benchmarks. Comprehensive simulation scenarios are designed and executed for a traffic network composed of nine four-way intersections. Obtained results for a few scenarios demonstrate the optimality of trained intelligent controllers using the cuckoo search method. The average performance of NN, ANFIS, and Q-learning controllers against the fixed-time controller are 44%, 39%, and 35%, respectively.