Corners, squares and urban identities: perceptions, attitudes and values

In February 2000, the new Victorian Labor Government announced that they were removing the western shard from Lab Architecture Studio's winning Melbourne Federation Square design. then under construction. The specific 'contested terrain' at the intersection of Flinders Street and Swanston Street Walk. Melbourne, allows the exploration of the politics of place construction over time, through an examination of Young and Jackson's Hotel [1861]. St Paul's Cathedral [1886). Flinders Street Station [1912]. the Westin Hotel [1999) and Federation Square. This site brings together architectural and social history, questions public space and identity, and looks at Melburnian's perceptions, attitudes and values. It further demonstrates that the fragmentation of the professions, and fragmentary histories. lead to the preservation of 'bits' of architecture and the destruction of the urban/landscape context, jeopardizing the Identity of place.<br />

Catholic intermarriages in Australia : attitudes to children, identity and sharing household responsibilities

A cursory glance of the human history shows a changing view about marriage on various aspects and levels. One of which is the level of people&rsquo;s exploration leading to marriage with a spouse that may have different articles of faith.<br /><br />This study&rsquo;s focal concern is on Australia&rsquo;s Catholics&rsquo; and Christians&rsquo; interfaith marriages, and its level of influence on attitudes to children, identity, and sharing household responsibilities. Expectations are predetermined from both parties but it can be discerned that with sound values, relationships can be rockbed strong.<br /><br />Raising a family for two individuals with distinct spiritual formation can bring multidisciplinary results. It may be a source of inspiration not only for children seeing their parents respecting each other&rsquo;s belief&mdash; for the love of fellow, own children, and especially the love that has flourished through the union of faith.<br />

St Johns wort modulates the toxicities and parmacokinetics of CPT-11 (Irontecan) in rats

CPT-11 is a DNA topoisomerase I inhibitor for the therapy of colorectal cancer, whereas St. Johnrsquos Wort (<i>Hypericum perforatum</i>, SJW) is a widely used herbal anti-depressant. This study aimed to investigate the effects of co-administered SJW on the toxicities and pharmacokinetics of CPT-11 and the underlying mechanisms. The body weight loss, gastrointestinal and hematological toxicities induced by CPT-11, and the pharmacokinetic parameters of CPT-11 were evaluated in rats pretreated with SJW or vehicle. Rats treated with CPT-11 alone experienced rapid decrease in body weight, whereas co-administration of SJW with CPT-11 resulted in lesser body weight loss. The gastrointestinal and hematological toxicities following CPT-11 injection were both alleviated in the presence of SJW. The rat pharmacokinetics of both CPT-11 and its metabolite SN-38 were significantly altered in presence of SJW. In conclusion, co-administered SJW significantly ameliorated the toxicities induced by CPT-11. The protective effect of SJW may be partially due to pharmacokinetic interaction between CPT-11 and SJW.<br />